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Receptor gastričnog inhibitornog polipeptida

Uredi veze

Izvor: Wikipedija

(Preusmjereno sa straniceGastrični inhibitorni polipeptid receptor)

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Receptor gastričnog inhibitornog polipeptida‎

Dostupne strukture

2QKH

Identifikatori

Simboli

GIPR; PGQTL2

Vanjski ID

OMIM: 137241MGI: 1352753HomoloGene: 20081IUPHAR:GIPGeneCards:GIPR Gene

Ontologija gena
Molekularna funkcija	•aktivnost transmembranskog signalnog receptora•aktivnost gastričnog inhibitornog peptidnog receptora•vezivanje peptidnog hormona
Celularna komponenta	•ćelijska membrana•integralno sa membranom
Biološki proces	•signalni put desenzitizacije G-protein spregnutog receptora•formiranje prekursorskih metabolita i energije•signalni put ćelijskog receptora

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

RefSeq (mRNA)

RefSeq (protein)

Lokacija (UCSC)

Chr 19:
46.17 - 46.19 Mb

Chr 7:
19.74 - 19.75 Mb

PubMed pretraga

[1]

[2]

Receptor gastričnog inhibitornog polipeptida (GIP-R,glukozno zavisni insulinotropni polipeptidni receptor) jeprotein koji je kod ljudi kodiranGIPRgenom.^[1]^[2] GIP-R je sedam transmembranski protein prisutan ubeta ćelijama upancreasu.^[3]^[4]

Funkcija

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Gastrični inhibitorni polipeptid (GIP, glukozno zavisni insulinotropni polipeptid) je 42 aminokiseline dug polipeptid koji sintetišuK ćelije dvanaestopalačnog itankih creva. On je originalno identifikovan kao sastojak stomačnog ekstrakta koji inhibira sekrecijuželudačne kiseline i oslobađanjegastrina, ali je naknadno pokazano da potentno stimuliše otpuštanjeinsulina u prisustvu povišenih nivoaglukoze. Insulinotropno dejstvo na pankreasne beta ćelije je stoga njegova glavna fiziološka uloga. Zajedno saglukagonu sličnim peptidom-1, GIP je u velikoj meri odgovoran za sekreciju insulina nakon jela. On učestvuje u nekoliko različitih oblika anaboličkog otpuštaja.^[1]

Reference

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↑^1,0^1,1„Entrez Gene: gastric inhibitory polypeptide receptor”.
↑Stoffel M, Fernald AA, Le Beau MM, Bell GI (August 1995). „Assignment of the gastric inhibitory polypeptide receptor gene (GIPR) to chromosome bands 19q13.2-q13.3 by fluorescence in situ hybridization”. Genomics 28 (3): 607–609. DOI:10.1006/geno.1995.1203. PMID 7490109.
↑„Gastrointestinal Hormones and Peptides”. Arhivirano izoriginala na datum 2007-12-06. Pristupljeno 24. 08. 2007.
↑Brubaker PL, Drucker DJ (2002). „Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors”. Recept. Channels 8 (3–4): 179–188. DOI:10.1080/10606820213687. PMID 12529935.

Literatura

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Yamada Y, Seino Y (2005). „Physiology of GIP--a lesson from GIP receptor knockout mice”. Horm. Metab. Res. 36 (11–12): 771–774. DOI:10.1055/s-2004-826162. PMID 15655707.
Gremlich S, Porret A, Hani EH i dr.. (1995). „Cloning, functional expression, and chromosomal localization of the human pancreatic islet glucose-dependent insulinotropic polypeptide receptor”. Diabetes 44 (10): 1202–1208. DOI:10.2337/diabetes.44.10.1202. PMID 7556958.
Volz A, Göke R, Lankat-Buttgereit B i dr.. (1995). „Molecular cloning, functional expression, and signal transduction of the GIP-receptor cloned from a human insulinoma”. FEBS Lett. 373 (1): 23–29. DOI:10.1016/0014-5793(95)01006-Z. PMID 7589426.
Usdin TB, Mezey E, Button DC i dr.. (1994). „Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain”. Endocrinology 133 (6): 2861–2870. DOI:10.1210/en.133.6.2861. PMID 8243312.
Yamada Y, Hayami T, Nakamura K i dr.. (1996). „Human gastric inhibitory polypeptide receptor: cloning of the gene (GIPR) and cDNA”. Genomics 29 (3): 773–776. DOI:10.1006/geno.1995.9937. PMID 8575774.
Gallwitz B, Witt M, Morys-Wortmann C i dr.. (1997). „GLP-1/GIP chimeric peptides define the structural requirements for specific ligand-receptor interaction of GLP-1”. Regul. Pept. 63 (1): 17–22. DOI:10.1016/0167-0115(96)00019-5. PMID 8795084.
N'Diaye N, Tremblay J, Hamet P i dr.. (1998). „Adrenocortical overexpression of gastric inhibitory polypeptide receptor underlies food-dependent Cushing's syndrome”. J. Clin. Endocrinol. Metab. 83 (8): 2781–2785. DOI:10.1210/jc.83.8.2781. PMID 9709947.
Tseng CC, Zhang XY (2000). „Role of G protein-coupled receptor kinases in glucose-dependent insulinotropic polypeptide receptor signaling”. Endocrinology 141 (3): 947–952. DOI:10.1210/en.141.3.947. PMID 10698169.
Bollag RJ, Zhong Q, Phillips P i dr.. (2000). „Osteoblast-derived cells express functional glucose-dependent insulinotropic peptide receptors”. Endocrinology 141 (3): 1228–1235. DOI:10.1210/en.141.3.1228. PMID 10698200.
Strausberg RL, Feingold EA, Grouse LH i dr.. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Baldacchino V, Oble S, Hamet P i dr.. (2003). „Partial characterisation of the 5' flanking region of the human GIP receptor (GIPR) gene”. Endocr. Res. 28 (4): 577–577. DOI:10.1081/ERC-120016843. PMID 12530665.
Antonini SR, N'Diaye N, Hamet P i dr.. (2003). „Analysis of the putative promoter region of the GIP receptor gene (GIPR) in GIP-dependent Cushing's syndrome (CS)”. Endocr. Res. 28 (4): 755–756. DOI:10.1081/ERC-120017003. PMID 12530694.
Manhart S, Hinke SA, McIntosh CH i dr.. (2003). „Structure-function analysis of a series of novel GIP analogues containing different helical length linkers”. Biochemistry 42 (10): 3081–3088. DOI:10.1021/bi026868e. PMID 12627975.
Ding KH, Zhong Q, Isales CM (2003). „Glucose-dependent insulinotropic peptide stimulates thymidine incorporation in endothelial cells: role of endothelin-1”. Am. J. Physiol. Endocrinol. Metab. 285 (2): E390–6. DOI:10.1152/ajpendo.00509.2002. PMID 12721154.
Grimwood J, Gordon LA, Olsen A i dr.. (2004). „The DNA sequence and biology of human chromosome 19”. Nature 428 (6982): 529–535. DOI:10.1038/nature02399. PMID 15057824.
Hansotia T, Baggio LL, Delmeire D i dr.. (2004). „Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPP-IV inhibitors”. Diabetes 53 (5): 1326–1335. DOI:10.2337/diabetes.53.5.1326. PMID 15111503.
Gerhard DS, Wagner L, Feingold EA i dr.. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–2127. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Baldacchino V, Oble S, Hamet P i dr.. (2005). „The Sp transcription factor family is involved in the cellular expression of the human GIP-R gene promoter”. Endocr. Res. 30 (4): 805–806. DOI:10.1081/ERC-200044046. PMID 15666829.

Povezano

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Glukagonska receptorska familija

Vanjske veze

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„Glucagon Receptor Family: GIP”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano izoriginala na datum 2016-03-03.
MeSHgastric+inhibitory+polypeptide+receptor

Transmembranski receptor:G protein spregnuti receptori

Klasa A:Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A,B,D) • α2 (A,B,C) • β1 • β2 • β3
Purinski	Adenozinski (A1,A2A,A2B,A3) • P2Y (1,2,4,5,6,8,9,10,11,12,13,14)
Serotoninski	(svi osim 5-HT3)5-HT1 (A,B,D,E,F) • 5-HT2 (A,B,C) • 5-HT (4,5A,6,7)
Drugi	Acetilholin (M1,M2,M3,M4,M5) • Dopamin (D1,D2,D3,D4,D5) • Histamin (H1,H2,H3,H4) • Melatonin (1A,1B,1C) • TAAR (1,2,3,5,6,8,9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1,2) • LTB4 (1,2) • FPRL1 • OXE • Prostaglandin (DP (1,2),EP (1,2,3,4),FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1,CB2,GPR (18,55,119)) • EBI2 • Estrogen • Slobodna masna kiselina (1,2,3,4) • Laktat • Lizofosfatidna kiselina (1,2,3,4,5,6) • Lizofosfolipid (1,2,3,4,5,6,7,8) • Niacin (1,2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1,2,3,4,5) • Sukcinat

Peptid

Neuropeptidni

B/W (1,2) • FF (1,2) • S • Y (1,2,4,5) • Neuromedin (B,U (1,2)) • Neurotenzin (1,2)

Drugi

Anafilatoksin (C3a,C5a) • Angiotenzin (1,2) • Apelin • Bombezin (BRS3,GRPR,NMBR) • Bradikinin (B1,B2) • Hemokin • Holecistokinin (A,B) • Endotelin (A,B) • Formil peptid (1,2,3) • FSH • Galanin (1,2,3) • GHB receptor • Gonadotropin-oslobađajući hormon (1,2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1,1L,D,E,F,G,X1,X2,X3,X4) • Melanokortin (1,2,3,4,5) • MCHR (1,2) • Motilin • Opioidni (δ,κ,μ,Nociceptin &ζ, ali neσ) • Oreksin (1,2) • Oksitocin • Prokineticin (1,2) • Prolaktin-oslobađajući peptid • Relaksin (1,2,3,4) • Somatostatin (1,2,3,4,5) • Tahikinin (1,2,3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A,1B,2)

Razno

Orfan	GPR (1,3,4,6,12,15,17,18,19,20,21,22,23,25,26,27,31,32,33,34,35,37,39,42,44,45,50,52,55,61,62,63,65,68,75,77,78,81,82,83,84,85,87,88,92,101,103,109A,109B,119,120,132,135,137B,139,141,142,146,148,149,150,151,152,153,160,161,162,171,173,174,176,177,182,183)
Drugi	Adrenomedulin • Mirisni • Opsin (3,4,5,1LW,1MW,1SW,RGR,RRH) • Proteazom-aktivirani (1,2,3,4) • SREB (1,2,3)

Klasa B:Sekretinu slični

Orfan

GPR (56,64,97,98,110,111,112,113,114,115,116,123,124,125,126,128,133,143,144,155,157)

Drugi

Moždano specifični angiogenezni inhibitor (1,2,3) • Cadherin (1,2,3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1,2) • EMR (1,2,3) • Glukagon (GR,GIPR,GLP1R,GLP2R) • Hormon rasta oslobađajući hormon • PACAPR1 • GPR • Latrofilin (1,2,3,ELTD1) • Metuselah-slični proteini • Paratiroidni hormon (1,2) • Sekretin • Vazoaktivni intestinalni peptid (1,2)

Klasa C:Metabotropni
glutamat /feromon

Ukus	TAS1R (1,2,3) • TAS2R (1,3,4,5,8,9,10,12,13,14,16,19,20,30,31,38,39,40,41,42,43,45,46,50)
Drugi	Kalcijum-detektujući receptor • GABA B (1,2) • Glutamatni receptor (Metabotropni glutamat (1,2,3,4,5,6,7,8)) • GPRC6A • GPR (156,158,179) • RAIG (1,2,3,4)

Klasa F:
Frizzled /Zaglađeni

Uvojiti	Frizzled (1,2,3,4,5,6,7,8,9,10)
Zaglađeni	Zaglađeni

B trdu:peptidi (nrpl/grfl/cytl/horl),receptori (lgic,enzr,gprc,igsr,intg,nrpr/grfr/cytr),itra (adap,gbpr,mapk),calc,lipd, signalni putevi (hedp,wntp,tgfp+mapp,notp,jakp,fsap,hipp,tlrp)

Izvor:https://sh.wikipedia.org/w/index.php?title=Receptor_gastričnog_inhibitornog_polipeptida&oldid=42506840

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