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GPRC6A

Uredi veze

Izvor: Wikipedija

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G protein spregnuti receptor, familija C, grupa 6, član A

Identifikatori

Simboli

GPRC6A; GPCR; bA86F4.3

Vanjski ID

OMIM: 613572MGI: 2429498HomoloGene: 17529IUPHAR:GPRC₆GeneCards:GPRC6A Gene

Ontologija gena
Molekularna funkcija	•aktivnost G-protein spregnutog receptora
Celularna komponenta	•ćelijska membrana•ćelijska površina•integralno sa membranom
Biološki proces	•kalcijum posredovan signalizacija•respons na aminokiselinski stimulus

Ortolozi

Vrsta

Čovek

Miš

RefSeq (mRNA)

RefSeq (protein)

Lokacija (UCSC)

Chr 6:
117.11 - 117.15 Mb

Chr 10:
51.33 - 51.35 Mb

PubMed pretraga

[1]

[2]

G protein spregnuti receptor familija C group 6 član A jeprotein koji je kod ljudi kodiranGPRC6Agenom.^[1] Ovaj receptor funkcioniše kao senzor L-aminokiselina,^[2]osteokalcina,^[3] isteroida.^[4]

Klinički značaj

[uredi |uredi kod]

GPRC6A je takođe povezan sa progresijomraka prostate, i pokazano je da posreduje brz, negenomiski respons ćelija kancera prostate natestosteron.^[5]

Reference

[uredi |uredi kod]

↑„Entrez Gene: GPRC6A G protein-coupled receptor, family C, group 6, member A”.
↑Wellendorph P, Hansen KB, Balsgaard A, Greenwood JR, Egebjerg J, Bräuner-Osborne H (2005). „Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids”. Mol. Pharmacol. 67 (3): 589–97. DOI:10.1124/mol.104.007559. PMID 15576628.
↑Pi M, Wu Y, Quarles LD (July 2011). „GPRC6A mediates responses to osteocalcin in β-cells in vitro and pancreas in vivo”. J. Bone Miner. Res. 26 (7): 1680–3. DOI:10.1002/jbmr.390. PMID 21425331.
↑Pi M, Parrill AL, Quarles LD (December 2010). „GPRC6A mediates the non-genomic effects of steroids”. J. Biol. Chem. 285 (51): 39953–64. DOI:10.1074/jbc.M110.158063. PMID 20947496.
↑Pi M, Quarles LD (June 2011). „GPRC6A regulates prostate cancer progression”. Prostate 72 (4): 399–409. DOI:10.1002/pros.21442. PMID 21681779.

Literatura

[uredi |uredi kod]

Harrington JJ, Sherf B, Rundlett S,et al. (2001). „Creation of genome-wide protein expression libraries using random activation of gene expression.”. Nat. Biotechnol. 19 (5): 440–5. DOI:10.1038/88107. PMID 11329013.
Takeda S, Kadowaki S, Haga T,et al. (2002). „Identification of G protein-coupled receptor genes from the human genome sequence.”. FEBS Lett. 520 (1–3): 97–101. DOI:10.1016/S0014-5793(02)02775-8. PMID 12044878.
Mungall AJ, Palmer SA, Sims SK,et al. (2003). „The DNA sequence and analysis of human chromosome 6”. Nature 425 (6960): 805–11. DOI:10.1038/nature02055. PMID 14574404.
Wellendorph P, Bräuner-Osborne H (2004). „Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor”. Gene 335: 37–46. DOI:10.1016/j.gene.2004.03.003. PMID 15194188.
Wellendorph P, Hansen KB, Balsgaard A,et al. (2005). „Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids”. Mol. Pharmacol. 67 (3): 589–97. DOI:10.1124/mol.104.007559. PMID 15576628.
Pi M, Faber P, Ekema G,et al. (2006). „Identification of a novel extracellular cation-sensing G-protein-coupled receptor”. J. Biol. Chem. 280 (48): 40201–9. DOI:10.1074/jbc.M505186200. PMC 1435382. PMID 16199532.

Vanjske veze

[uredi |uredi kod]

MeSHGPRC6A+protein,+human
„Calcium-Sensing Receptors: GPRC₆”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano izoriginala na datum 2016-03-03.

Transmembranski receptor:G protein spregnuti receptori

Klasa A:Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A,B,D) • α2 (A,B,C) • β1 • β2 • β3
Purinski	Adenozinski (A1,A2A,A2B,A3) • P2Y (1,2,4,5,6,8,9,10,11,12,13,14)
Serotoninski	(svi osim 5-HT3)5-HT1 (A,B,D,E,F) • 5-HT2 (A,B,C) • 5-HT (4,5A,6,7)
Drugi	Acetilholin (M1,M2,M3,M4,M5) • Dopamin (D1,D2,D3,D4,D5) • Histamin (H1,H2,H3,H4) • Melatonin (1A,1B,1C) • TAAR (1,2,3,5,6,8,9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1,2) • LTB4 (1,2) • FPRL1 • OXE • Prostaglandin (DP (1,2),EP (1,2,3,4),FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1,CB2,GPR (18,55,119)) • EBI2 • Estrogen • Slobodna masna kiselina (1,2,3,4) • Laktat • Lizofosfatidna kiselina (1,2,3,4,5,6) • Lizofosfolipid (1,2,3,4,5,6,7,8) • Niacin (1,2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1,2,3,4,5) • Sukcinat

Peptid

Neuropeptidni

B/W (1,2) • FF (1,2) • S • Y (1,2,4,5) • Neuromedin (B,U (1,2)) • Neurotenzin (1,2)

Drugi

Anafilatoksin (C3a,C5a) • Angiotenzin (1,2) • Apelin • Bombezin (BRS3,GRPR,NMBR) • Bradikinin (B1,B2) • Hemokin • Holecistokinin (A,B) • Endotelin (A,B) • Formil peptid (1,2,3) • FSH • Galanin (1,2,3) • GHB receptor • Gonadotropin-oslobađajući hormon (1,2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1,1L,D,E,F,G,X1,X2,X3,X4) • Melanokortin (1,2,3,4,5) • MCHR (1,2) • Motilin • Opioidni (δ,κ,μ,Nociceptin &ζ, ali neσ) • Oreksin (1,2) • Oksitocin • Prokineticin (1,2) • Prolaktin-oslobađajući peptid • Relaksin (1,2,3,4) • Somatostatin (1,2,3,4,5) • Tahikinin (1,2,3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A,1B,2)

Razno

Orfan	GPR (1,3,4,6,12,15,17,18,19,20,21,22,23,25,26,27,31,32,33,34,35,37,39,42,44,45,50,52,55,61,62,63,65,68,75,77,78,81,82,83,84,85,87,88,92,101,103,109A,109B,119,120,132,135,137B,139,141,142,146,148,149,150,151,152,153,160,161,162,171,173,174,176,177,182,183)
Drugi	Adrenomedulin • Mirisni • Opsin (3,4,5,1LW,1MW,1SW,RGR,RRH) • Proteazom-aktivirani (1,2,3,4) • SREB (1,2,3)

Klasa B:Sekretinu slični

Orfan

GPR (56,64,97,98,110,111,112,113,114,115,116,123,124,125,126,128,133,143,144,155,157)

Drugi

Moždano specifični angiogenezni inhibitor (1,2,3) • Cadherin (1,2,3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1,2) • EMR (1,2,3) • Glukagon (GR,GIPR,GLP1R,GLP2R) • Hormon rasta oslobađajući hormon • PACAPR1 • GPR • Latrofilin (1,2,3,ELTD1) • Metuselah-slični proteini • Paratiroidni hormon (1,2) • Sekretin • Vazoaktivni intestinalni peptid (1,2)

Klasa C:Metabotropni
glutamat /feromon

Ukus	TAS1R (1,2,3) • TAS2R (1,3,4,5,8,9,10,12,13,14,16,19,20,30,31,38,39,40,41,42,43,45,46,50)
Drugi	Kalcijum-detektujući receptor • GABA B (1,2) • Glutamatni receptor (Metabotropni glutamat (1,2,3,4,5,6,7,8)) • GPRC6A • GPR (156,158,179) • RAIG (1,2,3,4)

Klasa F:
Frizzled /Zaglađeni

Uvojiti	Frizzled (1,2,3,4,5,6,7,8,9,10)
Zaglađeni	Zaglađeni

B trdu:peptidi (nrpl/grfl/cytl/horl),receptori (lgic,enzr,gprc,igsr,intg,nrpr/grfr/cytr),itra (adap,gbpr,mapk),calc,lipd, signalni putevi (hedp,wntp,tgfp+mapp,notp,jakp,fsap,hipp,tlrp)

Izvor:https://sh.wikipedia.org/w/index.php?title=GPRC6A&oldid=42506605

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