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GPR50

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Izvor: Wikipedija

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G protein-spregnuti receptor 50

Identifikatori

Simboli

GPR50; H9; MGC125342

Vanjski ID

OMIM: 300207MGI: 1333877HomoloGene: 3113IUPHAR:GPR50GeneCards:GPR50 Gene

Ontologija gena
Molekularna funkcija	•aktivnost rodopsinu sličnog receptora•receptorska aktivnost
Celularna komponenta	•integralno sa ćelijskom membranom•membrana
Biološki proces	•prenos signala•signalni put G-protein spregnutog receptora•međućelijska signalizacija

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

RefSeq (mRNA)

RefSeq (protein)

Lokacija (UCSC)

Chr X:
150.1 - 150.1 Mb

Chr X:
67.92 - 67.93 Mb

PubMed pretraga

[1]

[2]

GPR50,G protein-spregnuti receptor 50, jeprotein koji je kod čoveka kodiranGPR50genom.^[1]^[2]^[3]

Funkcija

[uredi |uredi kod]

GPR50 je članGPCR familijeintegralnih membranskih proteina. On je sličanmelatoninskom receptoru.^[2] GPR50 ima sposobnost formiranja heterodimera saMT₁ iMT₂ melatoninskim receptorima. Dok GPR50 nema uticaja na MT₂ funkciju, on sprečava MT₁ da vežemelatonin i formira kompleks saG proteinima.^[4]

Klinički značaj

[uredi |uredi kod]

OdređenipolimorfizmiGPR50 gena kod žena su povezani sa povišenim rizikom razvojabipolarnog poremećaja,kliničkom depresijom, išizofrenijom.^[5] DrugiGPR50 genski polimorfizmi uslovljavaju povišenje nivoa cirkulišućihtriglicerida i sniženje nivoa cirkulišućihlipoproteina visoke gustine.^[6]

Literatura

[uredi |uredi kod]

↑„Entrez Gene: GPR50 G protein-coupled receptor 50”.
↑^2,0^2,1Reppert SM, Weaver DR, Ebisawa T, Mahle CD, Kolakowski LF (May 1996). „Cloning of a melatonin-related receptor from human pituitary”. FEBS letters 386 (2-3): 219–24. DOI:10.1016/0014-5793(96)00437-1. PMID 8647286.
↑Gubitz AK, Reppert SM (January 1999). „Assignment of the melatonin-related receptor to human chromosome X (GPR50) and mouse chromosome X (Gpr50)”. Genomics 55 (2): 248–51. DOI:10.1006/geno.1998.5661. PMID 9933574.
↑Levoye A, Dam J, Ayoub MA, Guillaume JL, Couturier C, Delagrange P, Jockers R (July 2006). „The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization”. The EMBO journal 25 (13): 3012–23. DOI:10.1038/sj.emboj.7601193. PMC 1500982. PMID 16778767.
↑Thomson PA, Wray NR, Thomson AM, Dunbar DR, Grassie MA, Condie A, Walker MT, Smith DJ, Pulford DJ, Muir W, Blackwood DH, Porteous DJ (May 2005). „Sex-specific association between bipolar affective disorder in women and GPR50, an X-linked orphan G protein-coupled receptor”. Molecular psychiatry 10 (5): 470–8. DOI:10.1038/sj.mp.4001593. PMID 15452587.
↑Bhattacharyya S, Luan J, Challis B, Keogh J, Montague C, Brennand J, Morten J, Lowenbeim S, Jenkins S, Farooqi IS, Wareham NJ, O'Rahilly S (April 2006). „Sequence variants in the melatonin-related receptor gene (GPR50) associate with circulating triglyceride and HDL levels”. Journal of lipid research 47 (4): 761–6. DOI:10.1194/jlr.M500338-JLR200. PMID 16436372.

Dodatna literatura

[uredi |uredi kod]

Reppert SM, Weaver DR, Ebisawa T,et al. (1996). „Cloning of a melatonin-related receptor from human pituitary.”. FEBS Lett. 386 (2-3): 219–24. DOI:10.1016/0014-5793(96)00437-1. PMID 8647286.
Gubitz AK, Reppert SM (1999). „Assignment of the melatonin-related receptor to human chromosome X (GPR50) and mouse chromosome X (Gpr50).”. Genomics 55 (2): 248–51. DOI:10.1006/geno.1998.5661. PMID 9933574.
Strausberg RL, Feingold EA, Grouse LH,et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Slominski A, Pisarchik A, Zbytek B,et al. (2003). „Functional activity of serotoninergic and melatoninergic systems expressed in the skin.”. J. Cell. Physiol. 196 (1): 144–53. DOI:10.1002/jcp.10287. PMID 12767050.
Suzuki Y, Yamashita R, Shirota M,et al. (2004). „Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.”. Genome Res. 14 (9): 1711–8. DOI:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Thomson PA, Wray NR, Thomson AM,et al. (2005). „Sex-specific association between bipolar affective disorder in women and GPR50, an X-linked orphan G protein-coupled receptor.”. Mol. Psychiatry 10 (5): 470–8. DOI:10.1038/sj.mp.4001593. PMID 15452587.
Bhattacharyya S, Luan J, Challis B,et al. (2006). „Sequence variants in the melatonin-related receptor gene (GPR50) associate with circulating triglyceride and HDL levels.”. J. Lipid Res. 47 (4): 761–6. DOI:10.1194/jlr.M500338-JLR200. PMID 16436372.
Levoye A, Dam J, Ayoub MA,et al. (2006). „The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization.”. EMBO J. 25 (13): 3012–23. DOI:10.1038/sj.emboj.7601193. PMC 1500982. PMID 16778767.

Transmembranski receptor:G protein spregnuti receptori

Klasa A:Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A,B,D) • α2 (A,B,C) • β1 • β2 • β3
Purinski	Adenozinski (A1,A2A,A2B,A3) • P2Y (1,2,4,5,6,8,9,10,11,12,13,14)
Serotoninski	(svi osim 5-HT3)5-HT1 (A,B,D,E,F) • 5-HT2 (A,B,C) • 5-HT (4,5A,6,7)
Drugi	Acetilholin (M1,M2,M3,M4,M5) • Dopamin (D1,D2,D3,D4,D5) • Histamin (H1,H2,H3,H4) • Melatonin (1A,1B,1C) • TAAR (1,2,3,5,6,8,9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1,2) • LTB4 (1,2) • FPRL1 • OXE • Prostaglandin (DP (1,2),EP (1,2,3,4),FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1,CB2,GPR (18,55,119)) • EBI2 • Estrogen • Slobodna masna kiselina (1,2,3,4) • Laktat • Lizofosfatidna kiselina (1,2,3,4,5,6) • Lizofosfolipid (1,2,3,4,5,6,7,8) • Niacin (1,2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1,2,3,4,5) • Sukcinat

Peptid

Neuropeptidni

B/W (1,2) • FF (1,2) • S • Y (1,2,4,5) • Neuromedin (B,U (1,2)) • Neurotenzin (1,2)

Drugi

Anafilatoksin (C3a,C5a) • Angiotenzin (1,2) • Apelin • Bombezin (BRS3,GRPR,NMBR) • Bradikinin (B1,B2) • Hemokin • Holecistokinin (A,B) • Endotelin (A,B) • Formil peptid (1,2,3) • FSH • Galanin (1,2,3) • GHB receptor • Gonadotropin-oslobađajući hormon (1,2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1,1L,D,E,F,G,X1,X2,X3,X4) • Melanokortin (1,2,3,4,5) • MCHR (1,2) • Motilin • Opioidni (δ,κ,μ,Nociceptin &ζ, ali neσ) • Oreksin (1,2) • Oksitocin • Prokineticin (1,2) • Prolaktin-oslobađajući peptid • Relaksin (1,2,3,4) • Somatostatin (1,2,3,4,5) • Tahikinin (1,2,3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A,1B,2)

Razno

Orfan	GPR (1,3,4,6,12,15,17,18,19,20,21,22,23,25,26,27,31,32,33,34,35,37,39,42,44,45,50,52,55,61,62,63,65,68,75,77,78,81,82,83,84,85,87,88,92,101,103,109A,109B,119,120,132,135,137B,139,141,142,146,148,149,150,151,152,153,160,161,162,171,173,174,176,177,182,183)
Drugi	Adrenomedulin • Mirisni • Opsin (3,4,5,1LW,1MW,1SW,RGR,RRH) • Proteazom-aktivirani (1,2,3,4) • SREB (1,2,3)

Klasa B:Sekretinu slični

Orfan

GPR (56,64,97,98,110,111,112,113,114,115,116,123,124,125,126,128,133,143,144,155,157)

Drugi

Moždano specifični angiogenezni inhibitor (1,2,3) • Cadherin (1,2,3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1,2) • EMR (1,2,3) • Glukagon (GR,GIPR,GLP1R,GLP2R) • Hormon rasta oslobađajući hormon • PACAPR1 • GPR • Latrofilin (1,2,3,ELTD1) • Metuselah-slični proteini • Paratiroidni hormon (1,2) • Sekretin • Vazoaktivni intestinalni peptid (1,2)

Klasa C:Metabotropni
glutamat /feromon

Ukus	TAS1R (1,2,3) • TAS2R (1,3,4,5,8,9,10,12,13,14,16,19,20,30,31,38,39,40,41,42,43,45,46,50)
Drugi	Kalcijum-detektujući receptor • GABA B (1,2) • Glutamatni receptor (Metabotropni glutamat (1,2,3,4,5,6,7,8)) • GPRC6A • GPR (156,158,179) • RAIG (1,2,3,4)

Klasa F:
Frizzled /Zaglađeni

Uvojiti	Frizzled (1,2,3,4,5,6,7,8,9,10)
Zaglađeni	Zaglađeni

B trdu:peptidi (nrpl/grfl/cytl/horl),receptori (lgic,enzr,gprc,igsr,intg,nrpr/grfr/cytr),itra (adap,gbpr,mapk),calc,lipd, signalni putevi (hedp,wntp,tgfp+mapp,notp,jakp,fsap,hipp,tlrp)

Izvor:https://sh.wikipedia.org/w/index.php?title=GPR50&oldid=42508646

Kategorija:

Ljudski proteini

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