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GPR4

Uredi veze

Izvor: Wikipedija

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G protein-spregnuti receptor 4

Identifikatori

Simboli

GPR4;

Vanjski ID

OMIM: 600551MGI: 2441992HomoloGene: 3867IUPHAR:GPR4GeneCards:GPR4 Gene

Ontologija gena
Molekularna funkcija	•aktivnost rodopsinu-sličnog receptora•receptorska aktivnost
Celularna komponenta	•integralno sa ćelijskom membranom•membrana
Biološki proces	•prenos signala•signalni put G-protein spregnutog receptora

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

n/a

RefSeq (mRNA)

RefSeq (protein)

Lokacija (UCSC)

Chr 19:
50.78 - 50.8 Mb

Chr 7:
18.37 - 18.38 Mb

PubMed pretraga

[1]

[2]

GPR4,G-protein spregnuti receptor 4, jeprotein koji je kod čoveka kodiranGPR4genom.^[1]^[2]

Povezano

[uredi |uredi kod]

Proton-registrujući G protein-spregnuti receptori

Literatura

[uredi |uredi kod]

↑Mahadevan MS, Baird S, Bailly JE, Shutler GG, Sabourin LA, Tsilfidis C, Neville CE, Narang M, Korneluk RG (Apr 1996). „Isolation of a novel G protein-coupled receptor (GPR4) localized to chromosome 19q13.3”. Genomics 30 (1): 84–8. DOI:10.1006/geno.1995.0013. PMID 8595909.
↑„Entrez Gene: GPR4 G protein-coupled receptor 4”.

Dodatna literatura

[uredi |uredi kod]

An S, Tsai C, Goetzl EJ (1996). „Cloning, sequencing and tissue distribution of two related G protein-coupled receptor candidates expressed prominently in human lung tissue.”. FEBS Lett. 375 (1-2): 121–4. DOI:10.1016/0014-5793(95)01196-L. PMID 7498459.
Heiber M, Docherty JM, Shah G,et al. (1995). „Isolation of three novel human genes encoding G protein-coupled receptors.”. DNA Cell Biol. 14 (1): 25–35. DOI:10.1089/dna.1995.14.25. PMID 7832990.
Zhu K, Baudhuin LM, Hong G,et al. (2001). „Sphingosylphosphorylcholine and lysophosphatidylcholine are ligands for the G protein-coupled receptor GPR4.”. J. Biol. Chem. 276 (44): 41325–35. DOI:10.1074/jbc.M008057200. PMID 11535583.
Strausberg RL, Feingold EA, Grouse LH,et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Lum H, Qiao J, Walter RJ,et al. (2003). „Inflammatory stress increases receptor for lysophosphatidylcholine in human microvascular endothelial cells.”. Am. J. Physiol. Heart Circ. Physiol. 285 (4): H1786–9. DOI:10.1152/ajpheart.00359.2003. PMID 12805023.
Ludwig MG, Vanek M, Guerini D,et al. (2003). „Proton-sensing G-protein-coupled receptors.”. Nature 425 (6953): 93–8. DOI:10.1038/nature01905. PMID 12955148.
Bektas M, Barak LS, Jolly PS,et al. (2003). „The G protein-coupled receptor GPR4 suppresses ERK activation in a ligand-independent manner.”. Biochemistry 42 (42): 12181–91. DOI:10.1021/bi035051y. PMID 14567679.
Sin WC, Zhang Y, Zhong W,et al. (2004). „G protein-coupled receptors GPR4 and TDAG8 are oncogenic and overexpressed in human cancers.”. Oncogene 23 (37): 6299–303. DOI:10.1038/sj.onc.1207838. PMID 15221007.
Gerhard DS, Wagner L, Feingold EA,et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kim KS, Ren J, Jiang Y,et al. (2005). „GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine.”. FASEB J. 19 (7): 819–21. DOI:10.1096/fj.04-2988fje. PMID 15857892.
Qiao J, Huang F, Naikawadi RP,et al. (2006). „Lysophosphatidylcholine impairs endothelial barrier function through the G protein-coupled receptor GPR4.”. Am. J. Physiol. Lung Cell Mol. Physiol. 291 (1): L91–101. DOI:10.1152/ajplung.00508.2005. PMID 16461426.
Huang F, Mehta D, Predescu S,et al. (2007). „A novel lysophospholipid- and pH-sensitive receptor, GPR4, in brain endothelial cells regulates monocyte transmigration.”. Endothelium 14 (1): 25–34. DOI:10.1080/10623320601177288. PMID 17364894.
Zou Y, Kim CH, Chung JH,et al. (2007). „Upregulation of endothelial adhesion molecules by lysophosphatidylcholine. Involvement of G protein-coupled receptor GPR4.”. FEBS J. 274 (10): 2573–84. DOI:10.1111/j.1742-4658.2007.05792.x. PMID 17437524.
Tobo M, Tomura H, Mogi C,et al. (2007). „Previously postulated "ligand-independent" signaling of GPR4 is mediated through proton-sensing mechanisms.”. Cell. Signal. 19 (8): 1745–53. DOI:10.1016/j.cellsig.2007.03.009. PMID 17462861.

Transmembranski receptor:G protein spregnuti receptori

Klasa A:Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A,B,D) • α2 (A,B,C) • β1 • β2 • β3
Purinski	Adenozinski (A1,A2A,A2B,A3) • P2Y (1,2,4,5,6,8,9,10,11,12,13,14)
Serotoninski	(svi osim 5-HT3)5-HT1 (A,B,D,E,F) • 5-HT2 (A,B,C) • 5-HT (4,5A,6,7)
Drugi	Acetilholin (M1,M2,M3,M4,M5) • Dopamin (D1,D2,D3,D4,D5) • Histamin (H1,H2,H3,H4) • Melatonin (1A,1B,1C) • TAAR (1,2,3,5,6,8,9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1,2) • LTB4 (1,2) • FPRL1 • OXE • Prostaglandin (DP (1,2),EP (1,2,3,4),FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1,CB2,GPR (18,55,119)) • EBI2 • Estrogen • Slobodna masna kiselina (1,2,3,4) • Laktat • Lizofosfatidna kiselina (1,2,3,4,5,6) • Lizofosfolipid (1,2,3,4,5,6,7,8) • Niacin (1,2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1,2,3,4,5) • Sukcinat

Peptid

Neuropeptidni

B/W (1,2) • FF (1,2) • S • Y (1,2,4,5) • Neuromedin (B,U (1,2)) • Neurotenzin (1,2)

Drugi

Anafilatoksin (C3a,C5a) • Angiotenzin (1,2) • Apelin • Bombezin (BRS3,GRPR,NMBR) • Bradikinin (B1,B2) • Hemokin • Holecistokinin (A,B) • Endotelin (A,B) • Formil peptid (1,2,3) • FSH • Galanin (1,2,3) • GHB receptor • Gonadotropin-oslobađajući hormon (1,2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1,1L,D,E,F,G,X1,X2,X3,X4) • Melanokortin (1,2,3,4,5) • MCHR (1,2) • Motilin • Opioidni (δ,κ,μ,Nociceptin &ζ, ali neσ) • Oreksin (1,2) • Oksitocin • Prokineticin (1,2) • Prolaktin-oslobađajući peptid • Relaksin (1,2,3,4) • Somatostatin (1,2,3,4,5) • Tahikinin (1,2,3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A,1B,2)

Razno

Orfan	GPR (1,3,4,6,12,15,17,18,19,20,21,22,23,25,26,27,31,32,33,34,35,37,39,42,44,45,50,52,55,61,62,63,65,68,75,77,78,81,82,83,84,85,87,88,92,101,103,109A,109B,119,120,132,135,137B,139,141,142,146,148,149,150,151,152,153,160,161,162,171,173,174,176,177,182,183)
Drugi	Adrenomedulin • Mirisni • Opsin (3,4,5,1LW,1MW,1SW,RGR,RRH) • Proteazom-aktivirani (1,2,3,4) • SREB (1,2,3)

Klasa B:Sekretinu slični

Orfan

GPR (56,64,97,98,110,111,112,113,114,115,116,123,124,125,126,128,133,143,144,155,157)

Drugi

Moždano specifični angiogenezni inhibitor (1,2,3) • Cadherin (1,2,3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1,2) • EMR (1,2,3) • Glukagon (GR,GIPR,GLP1R,GLP2R) • Hormon rasta oslobađajući hormon • PACAPR1 • GPR • Latrofilin (1,2,3,ELTD1) • Metuselah-slični proteini • Paratiroidni hormon (1,2) • Sekretin • Vazoaktivni intestinalni peptid (1,2)

Klasa C:Metabotropni
glutamat /feromon

Ukus	TAS1R (1,2,3) • TAS2R (1,3,4,5,8,9,10,12,13,14,16,19,20,30,31,38,39,40,41,42,43,45,46,50)
Drugi	Kalcijum-detektujući receptor • GABA B (1,2) • Glutamatni receptor (Metabotropni glutamat (1,2,3,4,5,6,7,8)) • GPRC6A • GPR (156,158,179) • RAIG (1,2,3,4)

Klasa F:
Frizzled /Zaglađeni

Uvojiti	Frizzled (1,2,3,4,5,6,7,8,9,10)
Zaglađeni	Zaglađeni

B trdu:peptidi (nrpl/grfl/cytl/horl),receptori (lgic,enzr,gprc,igsr,intg,nrpr/grfr/cytr),itra (adap,gbpr,mapk),calc,lipd, signalni putevi (hedp,wntp,tgfp+mapp,notp,jakp,fsap,hipp,tlrp)

Izvor:https://sh.wikipedia.org/w/index.php?title=GPR4&oldid=42506498

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