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GABBR2

Uredi veze

Izvor: Wikipedija

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Receptor 2 gama-aminobuterne kiseline B

Identifikatori

Simboli

GABBR2; GABABR2; GPR51; GPRC3B; HG20; HRIHFB2099

Vanjski ID

OMIM: 607340MGI: 2386030HomoloGene: 55902IUPHAR:GABA_B2GeneCards:GABBR2 Gene

Ontologija gena
Molekularna funkcija	•aktivnost prenosnika signala•receptorska aktivnost•aktivnost G-protein spregnutog GABA receptora
Celularna komponenta	•citoplazma•ćelijska membrana•integralno sa ćelijskom membranom•ćelijski spoj•neuronska projekcija•sinapsa•postsinaptička membrana
Biološki proces	•signalni put G-protein spregnutog receptora•negativna regulacija aktivnosti adenilat ciklaze•signalni put gama-aminobuterne kiseline•sinaptička transmisija

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

RefSeq (mRNA)

RefSeq (protein)

Lokacija (UCSC)

Chr 9:
101.05 - 101.47 Mb

Chr 4:
46.68 - 47 Mb

PubMed pretraga

[1]

[2]

Receptor 2 gama-aminobuterne kiseline B (GABA_B1) je podjedinicaG protein spregnutog receptora koja je kod ljudi kodiranaGABBR2genom.^[1]

B-tip receptora zaneurotransmiter GABA (gama-aminobuterna kiselina) inhibira neuronsku aktivnost putem G protein spregnutog sistema sekundarnih glasnika, koji reguliše oslobađanje neurotransmiter, aktivnost jonskih kanala iadenilil ciklaze.^[1]

Interakcije

[uredi |uredi kod]

Poznato je da GABBR2 formirainterakcije saGABBR1.^[2]

Reference

[uredi |uredi kod]

↑^1,0^1,1„Entrez Gene: GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2”.
↑White, J H; Wise A, Main M J, Green A, Fraser N J, Disney G H, Barnes A A, Emson P, Foord S M, Marshall F H (December 1998). „Heterodimerization is required for the formation of a functional GABA(B) receptor”. Nature (ENGLAND) 396 (6712): 679–82. DOI:10.1038/25354. ISSN 0028-0836. PMID 9872307.

Literatura

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White JH, Wise A, Main MJ i dr.. (1999). „Heterodimerization is required for the formation of a functional GABA(B) receptor”. Nature 396 (6712): 679–82. DOI:10.1038/25354. PMID 9872316.
Ng GY, Clark J, Coulombe N i dr.. (1999). „Identification of a GABAB receptor subunit, gb2, required for functional GABAB receptor activity”. J. Biol. Chem. 274 (12): 7607–10. DOI:10.1074/jbc.274.12.7607. PMID 10075644.
Ng GY, McDonald T, Bonnert T i dr.. (1999). „Cloning of a novel G-protein-coupled receptor GPR 51 resembling GABAB receptors expressed predominantly in nervous tissues and mapped proximal to the hereditary sensory neuropathy type 1 locus on chromosome 9”. Genomics 56 (3): 288–95. DOI:10.1006/geno.1998.5706. PMID 10087195.
Martin SC, Russek SJ, Farb DH (1999). „Molecular identification of the human GABABR2: cell surface expression and coupling to adenylyl cyclase in the absence of GABABR1”. Mol. Cell. Neurosci. 13 (3): 180–91. DOI:10.1006/mcne.1999.0741. PMID 10328880.
Clark JA, Mezey E, Lam AS, Bonner TI (2000). „Distribution of the GABA(B) receptor subunit gb2 in rat CNS”. Brain Res. 860 (1–2): 41–52. DOI:10.1016/S0006-8993(00)01958-2. PMID 10727622.
Sullivan R, Chateauneuf A, Coulombe N i dr.. (2000). „Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor”. J. Pharmacol. Exp. Ther. 293 (2): 460–7. PMID 10773016.
White JH, McIllhinney RA, Wise A i dr.. (2001). „The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx”. Proc. Natl. Acad. Sci. U.S.A. 97 (25): 13967–72. DOI:10.1073/pnas.240452197. PMC 17684. PMID 11087824.
Kitano J, Kimura K, Yamazaki Y i dr.. (2002). „Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins”. J. Neurosci. 22 (4): 1280–9. PMID 11850456.
Salim K, Fenton T, Bacha J i dr.. (2002). „Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation”. J. Biol. Chem. 277 (18): 15482–5. DOI:10.1074/jbc.M201539200. PMID 11854302.
Strausberg RL, Feingold EA, Grouse LH i dr.. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Furtinger S, Pirker S, Czech T i dr.. (2004). „Increased expression of gamma-aminobutyric acid type B receptors in the hippocampus of patients with temporal lobe epilepsy”. Neurosci. Lett. 352 (2): 141–5. DOI:10.1016/j.neulet.2003.08.046. PMID 14625043.
Waldvogel HJ, Billinton A, White JH i dr.. (2004). „Comparative cellular distribution of GABAA and GABAB receptors in the human basal ganglia: immunohistochemical colocalization of the alpha 1 subunit of the GABAA receptor, and the GABABR1 and GABABR2 receptor subunits”. J. Comp. Neurol. 470 (4): 339–56. DOI:10.1002/cne.20005. PMID 14961561.
Balasubramanian S, Teissére JA, Raju DV, Hall RA (2004). „Hetero-oligomerization between GABAA and GABAB receptors regulates GABAB receptor trafficking”. J. Biol. Chem. 279 (18): 18840–50. DOI:10.1074/jbc.M313470200. PMID 14966130.
Uezono Y, Kaibara M, Hayashi H i dr.. (2004). „Characterization of GABAB receptor in the human colon”. J. Pharmacol. Sci. 94 (2): 211–3. DOI:10.1254/jphs.94.211. PMID 14978362.
Humphray SJ, Oliver K, Hunt AR i dr.. (2004). „DNA sequence and analysis of human chromosome 9”. Nature 429 (6990): 369–74. DOI:10.1038/nature02465. PMC 2734081. PMID 15164053.
Gerhard DS, Wagner L, Feingold EA i dr.. (2004). „The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Hlavackova V, Goudet C, Kniazeff J i dr.. (2005). „Evidence for a single heptahelical domain being turned on upon activation of a dimeric GPCR”. EMBO J. 24 (3): 499–509. DOI:10.1038/sj.emboj.7600557. PMC 548662. PMID 15660124.
DeGiorgis JA, Jaffe H, Moreira JE i dr.. (2005). „Phosphoproteomic analysis of synaptosomes from human cerebral cortex”. J. Proteome Res. 4 (2): 306–15. DOI:10.1021/pr0498436. PMID 15822905.
Rual JF, Venkatesan K, Hao T i dr.. (2005). „Towards a proteome-scale map of the human protein-protein interaction network”. Nature 437 (7062): 1173–8. DOI:10.1038/nature04209. PMID 16189514.
Osawa Y, Xu D, Sternberg D i dr.. (2006). „Functional expression of the GABAB receptor in human airway smooth muscle”. Am. J. Physiol. Lung Cell Mol. Physiol. 291 (5): L923–31. DOI:10.1152/ajplung.00185.2006. PMID 16829628.

Povezano

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GABAB receptor

Vanjske veze

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„GABA_B Receptors: GABA_B2”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano izoriginala na datum 2014-08-08.

Transmembranski receptor:G protein spregnuti receptori

Klasa A:Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A,B,D) • α2 (A,B,C) • β1 • β2 • β3
Purinski	Adenozinski (A1,A2A,A2B,A3) • P2Y (1,2,4,5,6,8,9,10,11,12,13,14)
Serotoninski	(svi osim 5-HT3)5-HT1 (A,B,D,E,F) • 5-HT2 (A,B,C) • 5-HT (4,5A,6,7)
Drugi	Acetilholin (M1,M2,M3,M4,M5) • Dopamin (D1,D2,D3,D4,D5) • Histamin (H1,H2,H3,H4) • Melatonin (1A,1B,1C) • TAAR (1,2,3,5,6,8,9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1,2) • LTB4 (1,2) • FPRL1 • OXE • Prostaglandin (DP (1,2),EP (1,2,3,4),FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1,CB2,GPR (18,55,119)) • EBI2 • Estrogen • Slobodna masna kiselina (1,2,3,4) • Laktat • Lizofosfatidna kiselina (1,2,3,4,5,6) • Lizofosfolipid (1,2,3,4,5,6,7,8) • Niacin (1,2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1,2,3,4,5) • Sukcinat

Peptid

Neuropeptidni

B/W (1,2) • FF (1,2) • S • Y (1,2,4,5) • Neuromedin (B,U (1,2)) • Neurotenzin (1,2)

Drugi

Anafilatoksin (C3a,C5a) • Angiotenzin (1,2) • Apelin • Bombezin (BRS3,GRPR,NMBR) • Bradikinin (B1,B2) • Hemokin • Holecistokinin (A,B) • Endotelin (A,B) • Formil peptid (1,2,3) • FSH • Galanin (1,2,3) • GHB receptor • Gonadotropin-oslobađajući hormon (1,2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1,1L,D,E,F,G,X1,X2,X3,X4) • Melanokortin (1,2,3,4,5) • MCHR (1,2) • Motilin • Opioidni (δ,κ,μ,Nociceptin &ζ, ali neσ) • Oreksin (1,2) • Oksitocin • Prokineticin (1,2) • Prolaktin-oslobađajući peptid • Relaksin (1,2,3,4) • Somatostatin (1,2,3,4,5) • Tahikinin (1,2,3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A,1B,2)

Razno

Orfan	GPR (1,3,4,6,12,15,17,18,19,20,21,22,23,25,26,27,31,32,33,34,35,37,39,42,44,45,50,52,55,61,62,63,65,68,75,77,78,81,82,83,84,85,87,88,92,101,103,109A,109B,119,120,132,135,137B,139,141,142,146,148,149,150,151,152,153,160,161,162,171,173,174,176,177,182,183)
Drugi	Adrenomedulin • Mirisni • Opsin (3,4,5,1LW,1MW,1SW,RGR,RRH) • Proteazom-aktivirani (1,2,3,4) • SREB (1,2,3)

Klasa B:Sekretinu slični

Orfan

GPR (56,64,97,98,110,111,112,113,114,115,116,123,124,125,126,128,133,143,144,155,157)

Drugi

Moždano specifični angiogenezni inhibitor (1,2,3) • Cadherin (1,2,3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1,2) • EMR (1,2,3) • Glukagon (GR,GIPR,GLP1R,GLP2R) • Hormon rasta oslobađajući hormon • PACAPR1 • GPR • Latrofilin (1,2,3,ELTD1) • Metuselah-slični proteini • Paratiroidni hormon (1,2) • Sekretin • Vazoaktivni intestinalni peptid (1,2)

Klasa C:Metabotropni
glutamat /feromon

Ukus	TAS1R (1,2,3) • TAS2R (1,3,4,5,8,9,10,12,13,14,16,19,20,30,31,38,39,40,41,42,43,45,46,50)
Drugi	Kalcijum-detektujući receptor • GABA B (1,2) • Glutamatni receptor (Metabotropni glutamat (1,2,3,4,5,6,7,8)) • GPRC6A • GPR (156,158,179) • RAIG (1,2,3,4)

Klasa F:
Frizzled /Zaglađeni

Uvojiti	Frizzled (1,2,3,4,5,6,7,8,9,10)
Zaglađeni	Zaglađeni

B trdu:peptidi (nrpl/grfl/cytl/horl),receptori (lgic,enzr,gprc,igsr,intg,nrpr/grfr/cytr),itra (adap,gbpr,mapk),calc,lipd, signalni putevi (hedp,wntp,tgfp+mapp,notp,jakp,fsap,hipp,tlrp)

Izvor:https://sh.wikipedia.org/w/index.php?title=GABBR2&oldid=42508234

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