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Endotelinski receptor tip A

Uredi veze

Izvor: Wikipedija

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Endotelinski receptor tip A

Identifikatori

Simboli

EDNRA; ETA; ETRA

Vanjski ID

OMIM: 131243MGI: 105923HomoloGene: 1478IUPHAR:ET_AGeneCards:EDNRA Gene

Ontologija gena
Molekularna funkcija	•aktivnost rodopsinu-sličnog receptora•aktivnost endotelin-A receptora•aktivnost fosfoinozitid fosfolipaze C•receptorska aktivnost•proteinsko vezivanje
Celularna komponenta	•integralno sa ćelijskom membranom•membrana
Biološki proces	•uobličavanje krvnih sudova•respons na hipoksiju•in utero embrionski razvoj•kontrakcije glatkih mišića•prenos signala•signalni put G-protein spregnutog receptora•aktivacija adenilat ciklaze•aktivacija fosfolipaze C•elevacija koncentracije citozolnih jona kalcijuma•razvoj srca•respiratorna gasna razmena•ćelijska proliferacija•razvoj neuralnih krest ćelija•glukozni transport•negativna regulacija cAMP biosintetičkog procesa•vazokonstrikcija

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

RefSeq (mRNA)

RefSeq (protein)

Lokacija (UCSC)

Chr 4:
148.62 - 148.69 Mb

Chr 8:
80.56 - 80.62 Mb

PubMed pretraga

[1]

[2]

Endotelinski receptor type A, iliET_A, je ljudskiG protein spregnuti receptor.^[1]

Interakcije

[uredi |uredi kod]

Za endotelinski receptor tipa A je bilo pokazano dainteraguje saHDAC7A^[2] iHTATIP.^[2]

Povezano

[uredi |uredi kod]

Endotelinski receptor

Reference

[uredi |uredi kod]

↑„Entrez Gene: EDNRA endothelin receptor type A”.
↑^2,0^2,1Lee, H J; Chun M, Kandror K V (May 2001). „Tip60 and HDAC7 interact with the endothelin receptor a and may be involved in downstream signaling”. J. Biol. Chem. (United States) 276 (20): 16597–600. DOI:10.1074/jbc.C000909200. ISSN 0021-9258. PMID 11262386.

Literatura

[uredi |uredi kod]

Arai H, Nakao K, Hosoda K,et al. (1993). „[Molecular cloning of human endothelin receptors and their expression in vascular endothelial cells and smooth muscle cells]”. Jpn. Circ. J. 56 Suppl 5: 1303–7. PMID 1291713.
Hosoda K, Nakao K, Tamura N,et al. (1992). „Organization, structure, chromosomal assignment, and expression of the gene encoding the human endothelin-A receptor.”. J. Biol. Chem. 267 (26): 18797–804. PMID 1326535.
Hayzer DJ, Rose PM, Lynch JS,et al. (1992). „Cloning and expression of a human endothelin receptor: subtype A.”. Am. J. Med. Sci. 304 (4): 231–8. DOI:10.1097/00000441-199210000-00002. PMID 1415318.
Hosoda K, Nakao K, Hiroshi-Arai,et al. (1991). „Cloning and expression of human endothelin-1 receptor cDNA.”. FEBS Lett. 287 (1–2): 23–6. DOI:10.1016/0014-5793(91)80007-P. PMID 1652463.
Cyr C, Huebner K, Druck T, Kris R (1992). „Cloning and chromosomal localization of a human endothelin ETA receptor”. Biochem. Biophys. Res. Commun. 181 (1): 184–90. DOI:10.1016/S0006-291X(05)81399-3. PMID 1659806.
Adachi M, Yang YY, Furuichi Y, Miyamoto C (1991). „Cloning and characterization of cDNA encoding human A-type endothelin receptor”. Biochem. Biophys. Res. Commun. 180 (3): 1265–72. DOI:10.1016/S0006-291X(05)81332-4. PMID 1719979.
Lin HY, Kaji EH, Winkel GK,et al. (1991). „Cloning and functional expression of a vascular smooth muscle endothelin 1 receptor”. Proc. Natl. Acad. Sci. U.S.A. 88 (8): 3185–9. DOI:10.1073/pnas.88.8.3185. PMC 51410. PMID 1849646.
Takigawa M, Sakurai T, Kasuya Y,et al. (1995). „Molecular identification of guanine-nucleotide-binding regulatory proteins which couple to endothelin receptors”. Eur. J. Biochem. 228 (1): 102–8. DOI:10.1111/j.1432-1033.1995.tb20236.x. PMID 7882989.
Kobayashi S, Tang R, Wang B,et al. (1994). „Binding and functional properties of endothelin receptor subtypes in the human prostate”. Mol. Pharmacol. 45 (2): 306–11. PMID 8114678.
Yang H, Tabuchi H, Furuichi Y, Miyamoto C (1993). „Molecular characterization of the 5'-flanking region of human genomic ETA gene”. Biochem. Biophys. Res. Commun. 190 (2): 332–9. DOI:10.1006/bbrc.1993.1052. PMID 8427579.
Elshourbagy NA, Korman DR, Wu HL,et al. (1993). „Molecular characterization and regulation of the human endothelin receptors”. J. Biol. Chem. 268 (6): 3873–9. PMID 8440682.
Miyamoto Y, Yoshimasa T, Arai H,et al. (1996). „Alternative RNA splicing of the human endothelin-A receptor generates multiple transcripts”. Biochem. J. 313 ( Pt 3): 795–801. PMC 1216980. PMID 8611157.
Horstmeyer A, Cramer H, Sauer T,et al. (1996). „Palmitoylation of endothelin receptor A. Differential modulation of signal transduction activity by post-translational modification”. J. Biol. Chem. 271 (34): 20811–9. DOI:10.1074/jbc.271.34.20811. PMID 8702836.
Freedman NJ, Ament AS, Oppermann M,et al. (1997). „Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase specificity”. J. Biol. Chem. 272 (28): 17734–43. DOI:10.1074/jbc.272.28.17734. PMID 9211925.
Bourgeois C, Robert B, Rebourcet R,et al. (1997). „Endothelin-1 and ETA receptor expression in vascular smooth muscle cells from human placenta: a new ETA receptor messenger ribonucleic acid is generated by alternative splicing of exon 3”. J. Clin. Endocrinol. Metab. 82 (9): 3116–23. DOI:10.1210/jc.82.9.3116. PMID 9284755.
Mao XQ, Gao PS, Roberts MH,et al. (1999). „Variants of endothelin-1 and its receptors in atopic asthma”. Biochem. Biophys. Res. Commun. 262 (1): 259–62. DOI:10.1006/bbrc.1999.1158. PMID 10448102.
Maggi M, Barni T, Fantoni G,et al. (2000). „Expression and biological effects of endothelin-1 in human gonadotropin-releasing hormone-secreting neurons”. J. Clin. Endocrinol. Metab. 85 (4): 1658–65. DOI:10.1210/jc.85.4.1658. PMID 10770212.
Shraga-Levine Z, Sokolovsky M (2000). „Functional coupling of G proteins to endothelin receptors is ligand and receptor subtype specific”. Cell. Mol. Neurobiol. 20 (3): 305–17. DOI:10.1023/A:1007010125316. PMID 10789830.
Lee HJ, Chun M, Kandror KV (2001). „Tip60 and HDAC7 interact with the endothelin receptor a and may be involved in downstream signaling”. J. Biol. Chem. 276 (20): 16597–600. DOI:10.1074/jbc.C000909200. PMID 11262386.
Paasche JD, Attramadal T, Sandberg C,et al. (2001). „Mechanisms of endothelin receptor subtype-specific targeting to distinct intracellular trafficking pathways”. J. Biol. Chem. 276 (36): 34041–50. DOI:10.1074/jbc.M103243200. PMID 11382773.

Vanjske veze

[uredi |uredi kod]

„Endothelin Receptors: ET_A”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano izoriginala na datum 2016-03-03.

Transmembranski receptor:G protein spregnuti receptori

Klasa A:Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A,B,D) • α2 (A,B,C) • β1 • β2 • β3
Purinski	Adenozinski (A1,A2A,A2B,A3) • P2Y (1,2,4,5,6,8,9,10,11,12,13,14)
Serotoninski	(svi osim 5-HT3)5-HT1 (A,B,D,E,F) • 5-HT2 (A,B,C) • 5-HT (4,5A,6,7)
Drugi	Acetilholin (M1,M2,M3,M4,M5) • Dopamin (D1,D2,D3,D4,D5) • Histamin (H1,H2,H3,H4) • Melatonin (1A,1B,1C) • TAAR (1,2,3,5,6,8,9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1,2) • LTB4 (1,2) • FPRL1 • OXE • Prostaglandin (DP (1,2),EP (1,2,3,4),FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1,CB2,GPR (18,55,119)) • EBI2 • Estrogen • Slobodna masna kiselina (1,2,3,4) • Laktat • Lizofosfatidna kiselina (1,2,3,4,5,6) • Lizofosfolipid (1,2,3,4,5,6,7,8) • Niacin (1,2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1,2,3,4,5) • Sukcinat

Peptid

Neuropeptidni

B/W (1,2) • FF (1,2) • S • Y (1,2,4,5) • Neuromedin (B,U (1,2)) • Neurotenzin (1,2)

Drugi

Anafilatoksin (C3a,C5a) • Angiotenzin (1,2) • Apelin • Bombezin (BRS3,GRPR,NMBR) • Bradikinin (B1,B2) • Hemokin • Holecistokinin (A,B) • Endotelin (A,B) • Formil peptid (1,2,3) • FSH • Galanin (1,2,3) • GHB receptor • Gonadotropin-oslobađajući hormon (1,2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1,1L,D,E,F,G,X1,X2,X3,X4) • Melanokortin (1,2,3,4,5) • MCHR (1,2) • Motilin • Opioidni (δ,κ,μ,Nociceptin &ζ, ali neσ) • Oreksin (1,2) • Oksitocin • Prokineticin (1,2) • Prolaktin-oslobađajući peptid • Relaksin (1,2,3,4) • Somatostatin (1,2,3,4,5) • Tahikinin (1,2,3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A,1B,2)

Razno

Orfan	GPR (1,3,4,6,12,15,17,18,19,20,21,22,23,25,26,27,31,32,33,34,35,37,39,42,44,45,50,52,55,61,62,63,65,68,75,77,78,81,82,83,84,85,87,88,92,101,103,109A,109B,119,120,132,135,137B,139,141,142,146,148,149,150,151,152,153,160,161,162,171,173,174,176,177,182,183)
Drugi	Adrenomedulin • Mirisni • Opsin (3,4,5,1LW,1MW,1SW,RGR,RRH) • Proteazom-aktivirani (1,2,3,4) • SREB (1,2,3)

Klasa B:Sekretinu slični

Orfan

GPR (56,64,97,98,110,111,112,113,114,115,116,123,124,125,126,128,133,143,144,155,157)

Drugi

Moždano specifični angiogenezni inhibitor (1,2,3) • Cadherin (1,2,3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1,2) • EMR (1,2,3) • Glukagon (GR,GIPR,GLP1R,GLP2R) • Hormon rasta oslobađajući hormon • PACAPR1 • GPR • Latrofilin (1,2,3,ELTD1) • Metuselah-slični proteini • Paratiroidni hormon (1,2) • Sekretin • Vazoaktivni intestinalni peptid (1,2)

Klasa C:Metabotropni
glutamat /feromon

Ukus	TAS1R (1,2,3) • TAS2R (1,3,4,5,8,9,10,12,13,14,16,19,20,30,31,38,39,40,41,42,43,45,46,50)
Drugi	Kalcijum-detektujući receptor • GABA B (1,2) • Glutamatni receptor (Metabotropni glutamat (1,2,3,4,5,6,7,8)) • GPRC6A • GPR (156,158,179) • RAIG (1,2,3,4)

Klasa F:
Frizzled /Zaglađeni

Uvojiti	Frizzled (1,2,3,4,5,6,7,8,9,10)
Zaglađeni	Zaglađeni

B trdu:peptidi (nrpl/grfl/cytl/horl),receptori (lgic,enzr,gprc,igsr,intg,nrpr/grfr/cytr),itra (adap,gbpr,mapk),calc,lipd, signalni putevi (hedp,wntp,tgfp+mapp,notp,jakp,fsap,hipp,tlrp)

Izvor:https://sh.wikipedia.org/w/index.php?title=Endotelinski_receptor_tip_A&oldid=42506117

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