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Eikozanoidni receptor

Izvor: Wikipedija

Eikozanoidni receptor jeintegralni membranski protein kojidetektuje prisustvoeikozanoidnih signalnih molekula. Većina, mada ne svi, suG protein spregnuti receptori. Primer ne-GPCR receptora koji vezuje eikozanoide jePPAR-γ.^[1]

Ovo su poznati humani eikozanoidni GPCR receptori grupisani po tipu eikozanoidnogliganda koji vezuju:^[2]^[3]

Leukotrien

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Leukotrieni:

CysLT₁ (Cisteinil leukotrienski receptor 1) -CYSLTR1
CysLT₂ (Cisteinil leukotrienski receptor 2) -CYSLTR2
BLT₁ (Leukotrienski B₄ receptor) -LTB4R
BLT₂ (Leukotrienski B₄ receptor 2) -LTB4R2

Lipoksin

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Lipoksini:

LXA4R (Formil peptidnom receptoru-sličan 1) -FPRL1

Oksoeikozanoid

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Oksoeikozanoid:^[4]

Oksoeikozanoidni (OXE) receptor 1 -OXER1

Prostanoid

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Prostanoidi:

PGD₂: DP-(PGD₂)
- DP₁ (Prostaglandin D2 receptor) -PTGDR
- DP₂ (GPR44) -GPR44
PGE₂:
- EP₁-(PGE₂) (PTGER1) -PTGER1
- EP₂-(PGE₂) (PTGER2) -PTGER2
- EP₃-(PGE₂) (PTGER3) -PTGER3
- EP₄-(PGE₂) (PTGER4) -PTGER4
PGF_2α: FP-(PGF_2α) (PTGFR) -PTGFR
PGI₂ (prostaciklin): IP-(PGI₂) (PTGIR) -PTGIR
TXA₂ (tromboksan): TP-(TXA₂) (TBXA2R) -TBXA2R

Reference

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↑DuBois RN, Gupta R, Brockman J, Reddy BS, Krakow SL, Lazar MA (1998). „The nuclear eicosanoid receptor, PPAR-γ, is aberrantly expressed in colonic cancers”. Carcinogenesis 19 (1): 49–53. DOI:10.1093/carcin/19.1.49. PMID 9472692.
↑Coleman RA, Smith WL, Narumiya S (1994). „International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes”. Pharmacol. Rev. 46 (2): 205–29. PMID 7938166.
↑Brink C, Dahlén SE, Drazen J, Evans JF, Hay DW, Nicosia S, Serhan CN, Shimizu T, Yokomizo T (2003). „International Union of Pharmacology XXXVII. Nomenclature for leukotriene and lipoxin receptors”. Pharmacol. Rev. 55 (1): 195–227. DOI:10.1124/pr.55.1.8. PMID 12615958.
↑Brink C, Dahlén SE, Drazen J, Evans JF, Hay DW, Rovati GE, Serhan CN, Shimizu T, Yokomizo T (2004). „International Union of Pharmacology XLIV. Nomenclature for the oxoeicosanoid receptor”. Pharmacol. Rev. 56 (1): 149–57. DOI:10.1124/pr.56.1.4. PMID 15001665.

Vanjske veze

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„Leukotriene Receptors”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano izoriginala na datum 2016-03-03.
„Prostanoid Receptors”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano izoriginala na datum 2021-04-15.
MeSHEicosanoid+receptors

Transmembranski receptor:G protein spregnuti receptori

Klasa A:Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A,B,D) • α2 (A,B,C) • β1 • β2 • β3
Purinski	Adenozinski (A1,A2A,A2B,A3) • P2Y (1,2,4,5,6,8,9,10,11,12,13,14)
Serotoninski	(svi osim 5-HT3)5-HT1 (A,B,D,E,F) • 5-HT2 (A,B,C) • 5-HT (4,5A,6,7)
Drugi	Acetilholin (M1,M2,M3,M4,M5) • Dopamin (D1,D2,D3,D4,D5) • Histamin (H1,H2,H3,H4) • Melatonin (1A,1B,1C) • TAAR (1,2,3,5,6,8,9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1,2) • LTB4 (1,2) • FPRL1 • OXE • Prostaglandin (DP (1,2),EP (1,2,3,4),FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1,CB2,GPR (18,55,119)) • EBI2 • Estrogen • Slobodna masna kiselina (1,2,3,4) • Laktat • Lizofosfatidna kiselina (1,2,3,4,5,6) • Lizofosfolipid (1,2,3,4,5,6,7,8) • Niacin (1,2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1,2,3,4,5) • Sukcinat

Peptid

Neuropeptidni

B/W (1,2) • FF (1,2) • S • Y (1,2,4,5) • Neuromedin (B,U (1,2)) • Neurotenzin (1,2)

Drugi

Anafilatoksin (C3a,C5a) • Angiotenzin (1,2) • Apelin • Bombezin (BRS3,GRPR,NMBR) • Bradikinin (B1,B2) • Hemokin • Holecistokinin (A,B) • Endotelin (A,B) • Formil peptid (1,2,3) • FSH • Galanin (1,2,3) • GHB receptor • Gonadotropin-oslobađajući hormon (1,2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1,1L,D,E,F,G,X1,X2,X3,X4) • Melanokortin (1,2,3,4,5) • MCHR (1,2) • Motilin • Opioidni (δ,κ,μ,Nociceptin &ζ, ali neσ) • Oreksin (1,2) • Oksitocin • Prokineticin (1,2) • Prolaktin-oslobađajući peptid • Relaksin (1,2,3,4) • Somatostatin (1,2,3,4,5) • Tahikinin (1,2,3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A,1B,2)

Razno

Orfan	GPR (1,3,4,6,12,15,17,18,19,20,21,22,23,25,26,27,31,32,33,34,35,37,39,42,44,45,50,52,55,61,62,63,65,68,75,77,78,81,82,83,84,85,87,88,92,101,103,109A,109B,119,120,132,135,137B,139,141,142,146,148,149,150,151,152,153,160,161,162,171,173,174,176,177,182,183)
Drugi	Adrenomedulin • Mirisni • Opsin (3,4,5,1LW,1MW,1SW,RGR,RRH) • Proteazom-aktivirani (1,2,3,4) • SREB (1,2,3)

Klasa B:Sekretinu slični

Orfan

GPR (56,64,97,98,110,111,112,113,114,115,116,123,124,125,126,128,133,143,144,155,157)

Drugi

Moždano specifični angiogenezni inhibitor (1,2,3) • Cadherin (1,2,3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1,2) • EMR (1,2,3) • Glukagon (GR,GIPR,GLP1R,GLP2R) • Hormon rasta oslobađajući hormon • PACAPR1 • GPR • Latrofilin (1,2,3,ELTD1) • Metuselah-slični proteini • Paratiroidni hormon (1,2) • Sekretin • Vazoaktivni intestinalni peptid (1,2)

Klasa C:Metabotropni
glutamat /feromon

Ukus	TAS1R (1,2,3) • TAS2R (1,3,4,5,8,9,10,12,13,14,16,19,20,30,31,38,39,40,41,42,43,45,46,50)
Drugi	Kalcijum-detektujući receptor • GABA B (1,2) • Glutamatni receptor (Metabotropni glutamat (1,2,3,4,5,6,7,8)) • GPRC6A • GPR (156,158,179) • RAIG (1,2,3,4)

Klasa F:
Frizzled /Zaglađeni

Uvojiti	Frizzled (1,2,3,4,5,6,7,8,9,10)
Zaglađeni	Zaglađeni

B trdu:peptidi (nrpl/grfl/cytl/horl),receptori (lgic,enzr,gprc,igsr,intg,nrpr/grfr/cytr),itra (adap,gbpr,mapk),calc,lipd, signalni putevi (hedp,wntp,tgfp+mapp,notp,jakp,fsap,hipp,tlrp)

p r u Membranski proteini,receptori:transmembranski receptori
Asijaloglikoproteinski receptor -Autoreceptori -Biogeno aminski receptor -Eikozanoidni receptor (Prostaglandinski receptor) -G protein-spregnuti receptor -Imunski receptor -N-Acetilglukozaminski receptor -Neuropilini -Neurotransmiterski receptor -Mirisni receptori -Proteazom-aktivirani receptor -Purinski receptor -Transferinski receptor

Izvor:https://sh.wikipedia.org/w/index.php?title=Eikozanoidni_receptor&oldid=42271737

Kategorija:

G protein spregnuti receptori

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