Receptor 8 efrinskog tipa A jeprotein koji je kod ljudi kodiranEPHA8genom.[1][2]
Ovaj gen kodira članaefrinske receptorske podfamilijeproteinskih tirozinskih kinaza. EPH i EPH-srodni receptori učestvuju u posredovanja događaja razvića, posebno unervnom sistemu. Receptori EPH podfamilije tipično imaju jedankinazni domen, ekstracelularni region koji sadrži domen bogatcisteinom i dva ponavljanjafibronektinskog tipa III. Efrinski receptori se dele u dve grupe na bazi sličnosti sekvenci njihovih ekstracelularnih domena i njihovih afiniteta vezivanja liganda efrina A i efrina B. Protein kodiran ovim genom funkcioniše kao receptor za efrin A2, A3 i A5, i učestvuje u posredovanju bliskih kontakta pri aksonskom navođenju tokom razvića nervnog sistemasisara.[2]
↑Choi, S; Park S (Sep 1999). „Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity”. Oncogene (ENGLAND) 18 (39): 5413–22. DOI:10.1038/sj.onc.1202917. ISSN0950-9232. PMID10498895.
Murai KK, Pasquale EB (2004). „Eph receptors, ephrins, and synaptic function.”. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry10 (4): 304–14. DOI:10.1177/1073858403262221. PMID15271258.
Park S, Sánchez MP (1997). „The Eek receptor, a member of the Eph family of tyrosine protein kinases, can be activated by three different Eph family ligands.”. Oncogene14 (5): 533–42. DOI:10.1038/sj.onc.1200857. PMID9053851.
Ephnomenclaturecommittee, (1997). „Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee.”. Cell90 (3): 403–4. DOI:10.1016/S0092-8674(00)80500-0. PMID9267020.
Lemke G (1998). „A coherent nomenclature for Eph receptors and their ligands.”. Mol. Cell. Neurosci.9 (5–6): 331–2. DOI:10.1006/mcne.1997.0630. PMID9361271.
Choi S, Park S (1999). „Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity.”. Oncogene18 (39): 5413–22. DOI:10.1038/sj.onc.1202917. PMID10498895.
