Movatterモバイル変換

[0]ホーム
URL:

Prijeđi na sadržaj
Wikipedija
Pretraga

Dekstroamfetamin

Izvor: Wikipedija
Dekstroamfetamin
Drugi naziviAmsustain, Dephadren, Dexacaps, Dexadrine
Identifikacija
CAS registarski broj51-64-9 DaY
PubChem[1][2]5826
ChemSpider[3]5621 DaY
DrugBankDB01576
KEGG[4]C07884
ChEBI4469
ChEMBL[5]CHEMBL612 DaY
ATC codeN06BA02
Jmol-3D slikeSlika 1

C[C@H](N)CC1=CC=CC=C1

InChI=1S/C9H13N/c1-8(10)7-9-5-3-2-4-6-9/h2-6,8H,7,10H2,1H3/t8-/m0/s1 DaY
Kod: KWTSXDURSIMDCE-QMMMGPOBSA-N DaY

Svojstva
Molekulska formulaC9H13N
Molarna masa135.21 g mol−1
Tačka topljenja

<

Tačka ključanja

203

Farmakologija
Načini upotrebeOralno
Vreme polu-uklanjanja iz organizma10-28 h

 DaY (šta je ovo?)  (verifikuj)

Ukoliko nije drugačije napomenuto, podaci se odnose nastandardno stanje (25 °C, 100 kPa) materijala

Infobox references

Dekstroamfetamin jeorgansko jedinjenje, koje sadrži 9atomaugljenika i imamolekulsku masu od 135,206Da.[6][7][8][9][10][11][12]

Osobine

[uredi |uredi kod]
OsobinaVrednost
Broj akceptora vodonika1
Broj donora vodonika1
Broj rotacionih veza2
Particioni koeficijent[13] (ALogP)1,6
Rastvorljivost[14] (logS, log(mol/L))-2,3
Polarna površina[15] (PSA,Å2)26,0

Reference

[uredi |uredi kod]
  1. ↑Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. ↑Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. ↑Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. ↑Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. ↑Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  6. ↑Yamada H, Baba T, Hirata Y, Oguri K, Yoshimura H: Studies on N-demethylation of methamphetamine by liver microsomes of guinea-pigs and rats: the role of flavin-containing mono-oxygenase and cytochrome P-450 systems. Xenobiotica. 1984 Nov;14(11):861-6.PMID6506758
  7. ↑Warneke L: Psychostimulants in psychiatry. Can J Psychiatry. 1990 Feb;35(1):3-10.PMID2180548
  8. ↑Wagner GJ, Rabkin R: Effects of dextroamphetamine on depression and fatigue in men with HIV: a double-blind, placebo-controlled trial. J Clin Psychiatry. 2000 Jun;61(6):436-40.PMID10901342
  9. ↑Martinsson L, Yang X, Beck O, Wahlgren NG, Eksborg S: Pharmacokinetics of dexamphetamine in acute stroke. Clin Neuropharmacol. 2003 Sep-Oct;26(5):270-6.PMID14520168
  10. ↑Butefisch CM, Davis BC, Sawaki L, Waldvogel D, Classen J, Kopylev L, Cohen LG: Modulation of use-dependent plasticity by d-amphetamine. Ann Neurol. 2002 Jan;51(1):59-68.PMID11782985
  11. ↑Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. DOI:10.1093/nar/gkq1126. PMC 3013709. PMID 21059682.  edit
  12. ↑David S. Wishart, Craig Knox, An Chi Guo, Dean Cheng, Savita Shrivastava, Dan Tzur, Bijaya Gautam, and Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res 36 (Database issue): D901-6. DOI:10.1093/nar/gkm958. PMC 2238889. PMID 18048412.  edit
  13. ↑Ghose, A.K., Viswanadhan V.N., and Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A 102: 3762-3772. DOI:10.1021/jp980230o. 
  14. ↑Tetko IV, Tanchuk VY, Kasheva TN, Villa AE. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488-1493. DOI:10.1021/ci000392t. PMID 11749573.  edit
  15. ↑Ertl P., Rohde B., Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714-3717. DOI:10.1021/jm000942e. PMID 11020286.  edit

Literatura

[uredi |uredi kod]

Vanjske veze

[uredi |uredi kod]
Portal Hemija
Dekstroamfetamin naWikimedijinoj ostavi
Izvor:https://sh.wikipedia.org/w/index.php?title=Dekstroamfetamin&oldid=42276628
Kategorije:
[8]ページ先頭
©2009-2026 Movatter.jp