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DDR1

Uredi veze

Izvor: Wikipedija

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Diskoidin domen receptor familija, izoforma 1

Identifikatori

Simboli

DDR1; CAK; CD167; DDR; EDDR1; MCK10; NEP; NTRK4; PTK3; PTK3A; RTK6; TRKE

Vanjski ID

OMIM: 600408MGI: 99216HomoloGene: 68212GeneCards:DDR1 Gene

Ontologija gena
Molekularna funkcija	•vezivanje nukleotida•aktivnost protein-tirozin kinaze•aktivnost transmembrankog receptora proteinske tirozin kinaze•aktivnost receptora•ATP vezivanje•aktivnost transferaze
Celularna komponenta	•integralno sa membranom plazme•membrana
Biološki proces	•fosforilacija proteinske aminokiseline•ćelijska adhezija•transmembranki receptor proteinska tirozin kinaza, signalni put

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

RefSeq (mRNA)

RefSeq (protein)

Lokacija (UCSC)

Chr c6_COX:
30.99 - 31.01 Mb

Chr 17:
35.29 - 35.31 Mb

PubMed pretraga

[1]

[2]

DDR1, iliCD167a (klaster diferencijacije 167a), je ljudskigen^[1] koji je pripadnik broj 1 familijereceptora s diskoidinskim domenom.

Receptorske tirozinske kinaze (RTK) igraju ključnu ulogu u komunikaciji ćelija sa njihovim mikro okruženjem. Ti molekuli su uključeni u regulaciju ćelijskog rasta, diferencijacije i metabolizma. Protein kodiran ovim genom je RTK koji je široko izražen u normalnim i transformisanim epitelnim ćelijama, i koji je aktivirankolagenom. Ovaj protein pripada potfamiliji receptora tirozin kinaza koje sadrže homologni region saDictyostelium discoideumproteinomdiskoidin I u njihovom ekstracelularnom domenu. Njegova auto-fosforilacija se postiže svim do sada testiranim kolagenima (tip I - VI).In situ studije iNorthern-blot analiza su pokazale da je izražavanje ovog protein ograničeno naepitelske ćelije, posebno u bubrezima, plućima, gastrointestinalnom traktu, i mozgu. Dodatno, ovaj protein je značajno preizražen i u nekoliko ljudskih tumora iz dojki, jajnika, jednjaka, pedijatrijskog mozga. Ovaj gen se nalazi nahromozomu 6p21.3 u blizini nekolikoHLA klasa I gena.Alternativno splajsovanje (engleski:splicing) ovog gena proizvodi nekolikotranskriptnih varijanti.^[1]

Reference

[uredi |uredi kod]

↑^1,0^1,1„Entrez Gene: DDR1 discoidin domain receptor family, member 1”.

Literatura

[uredi |uredi kod]

Edelhoff S, Sweetser DA, Disteche CM (1995). „Mapping of the NEP receptor tyrosine kinase gene to human chromosome 6p21.3 and mouse chromosome 17C.”. Genomics 25 (1): 309–11. DOI:10.1016/0888-7543(95)80144-B. PMID 7774938.
Shelling AN, Butler R, Jones T,et al. (1995). „Localization of an epithelial-specific receptor kinase (EDDR1) to chromosome 6q16.”. Genomics 25 (2): 584–7. DOI:10.1016/0888-7543(95)80065-T. PMID 7789998.
Weiner TM, Liu ET, Craven RJ, Cance WG (1995). „Expression of growth factor receptors, the focal adhesion kinase, and other tyrosine kinases in human soft tissue tumors.”. Ann. Surg. Oncol. 1 (1): 18–27. DOI:10.1007/BF02303537. PMID 7834423.
Laval S, Butler R, Shelling AN,et al. (1995). „Isolation and characterization of an epithelial-specific receptor tyrosine kinase from an ovarian cancer cell line.”. Cell Growth Differ. 5 (11): 1173–83. PMID 7848919.
Kato JY, Matsuoka M, Strom DK, Sherr CJ (1994). „Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase.”. Mol. Cell. Biol. 14 (4): 2713–21. PMID 8139570.
Di Marco E, Cutuli N, Guerra L,et al. (1993). „Molecular cloning of trkE, a novel trk-related putative tyrosine kinase receptor isolated from normal human keratinocytes and widely expressed by normal human tissues.”. J. Biol. Chem. 268 (32): 24290–5. PMID 8226977.
Perez JL, Shen X, Finkernagel S,et al. (1994). „Identification and chromosomal mapping of a receptor tyrosine kinase with a putative phospholipid binding sequence in its ectodomain.”. Oncogene 9 (1): 211–9. PMID 8302582.
Johnson JD, Edman JC, Rutter WJ (1993). „A receptor tyrosine kinase found in breast carcinoma cells has an extracellular discoidin I-like domain.”. Proc. Natl. Acad. Sci. U.S.A. 90 (12): 5677–81. DOI:10.1073/pnas.90.12.5677. PMID 8390675.
Perez JL, Jing SQ, Wong TW (1996). „Identification of two isoforms of the Cak receptor kinase that are coexpressed in breast tumor cell lines.”. Oncogene 12 (7): 1469–77. PMID 8622863.
Valent A, Meddeb M, Danglot G,et al. (1996). „Assignment of the NTRK4 (trkE) gene to chromosome 6p21.”. Hum. Genet. 98 (1): 12–5. DOI:10.1007/s004390050152. PMID 8682498.
Playford MP, Butler RJ, Wang XC,et al. (1996). „The genomic structure of discoidin receptor tyrosine kinase.”. Genome Res. 6 (7): 620–7. DOI:10.1101/gr.6.7.620. PMID 8796349.
Sakuma S, Saya H, Tada M,et al. (1997). „Receptor protein tyrosine kinase DDR is up-regulated by p53 protein.”. FEBS Lett. 398 (2-3): 165–9. DOI:10.1016/S0014-5793(96)01234-3. PMID 8977099.
Nemoto T, Ohashi K, Akashi T,et al. (1998). „Overexpression of protein tyrosine kinases in human esophageal cancer.”. Pathobiology 65 (4): 195–203. DOI:10.1159/000164123. PMID 9396043.
Tanaka K, Nagayama Y, Nakano T,et al. (1998). „Expression profile of receptor-type protein tyrosine kinase genes in the human thyroid.”. Endocrinology 139 (3): 852–8. DOI:10.1210/en.139.3.852. PMID 9492013.
Vogel W, Gish GD, Alves F, Pawson T (1998). „The discoidin domain receptor tyrosine kinases are activated by collagen.”. Mol. Cell 1 (1): 13–23. DOI:10.1016/S1097-2765(00)80003-9. PMID 9659899.
Shrivastava A, Radziejewski C, Campbell E,et al. (1998). „An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors.”. Mol. Cell 1 (1): 25–34. DOI:10.1016/S1097-2765(00)80004-0. PMID 9659900.
Vogel W, Brakebusch C, Fässler R,et al. (2000). „Discoidin domain receptor 1 is activated independently of beta(1) integrin.”. J. Biol. Chem. 275 (8): 5779–84. DOI:10.1074/jbc.275.8.5779. PMID 10681566.
Foehr ED, Tatavos A, Tanabe E,et al. (2000). „Discoidin domain receptor 1 (DDR1) signaling in PC12 cells: activation of juxtamembrane domains in PDGFR/DDR/TrkA chimeric receptors.”. FASEB J. 14 (7): 973–81. PMID 10783152.
Weiner HL, Huang H, Zagzag D,et al. (2001). „Consistent and selective expression of the discoidin domain receptor-1 tyrosine kinase in human brain tumors.”. Neurosurgery 47 (6): 1400–9. DOI:10.1097/00006123-200012000-00028. PMID 11126911.
Mohan RR, Mohan RR, Wilson SE (2001). „Discoidin domain receptor (DDR) 1 and 2: collagen-activated tyrosine kinase receptors in the cornea.”. Exp. Eye Res. 72 (1): 87–92. DOI:10.1006/exer.2000.0932. PMID 11133186.

Proteinske kinaze:Tirozinske kinaze (EC 2.7.10)

Receptorske tirozinske kinaze (EC 2.7.10.1)

Receptori faktora rasta

EGF receptorska familija	EGFR • ERBB2 • ERBB3 • ERBB4
Insulinska receptorska familija	IGF1R • INSR • INSRR
PDGF receptorska familija	CSF1R • FLT3 • KIT • PDGFR (PDGFRA,PDGFRB)
FGF receptorska familija	FGFR1 • FGFR2 • FGFR3 • FGFR4
VEGF receptorska familija	VEGFR1 • VEGFR2 • VEGFR3 • VEGFR4
HGF receptorska familija	MET • RON
Trk receptorska familija	NTRK1 • NTRK2 • NTRK3

EPH receptorska familija

EPHA1 • EPHA2 • EPHA3 • EPHA4 • EPHA5 • EPHA6 • EPHA7 • EPHA8 • EPHB1 • EPHB2 • EPHB3 • EPHB4 • EPHB5 • EPHB6 • EPHX

LTK receptorska familija

LTK • ALK

TIE receptorska familija

TIE • TEK

ROR receptorska familija

ROR1 • ROR2

DDR receptorska familija

DDR1 • DDR2

PTK7 receptorska familija

PTK7

RYK receptorska familija

RYK

MuSK receptorska familija

MUSK

ROS receptorska familija

ROS1

AATYK receptorska familija

AATYK • AATYK2 • AATYK3

AXL receptorska familija

AXL • MER • TYRO3

RET receptorska familija

RET

nekategorisani

STYK1

Nereceptorske tirozinske kinaze (EC 2.7.10.2)

ABL familija	ABL1 • ARG
ACK familija	ACK1 • TNK1
CSK familija	CSK • MATK
FAK familija	FAK • PYK2
FES familija	FES • FER
FRK familija	FRK • BRK • SRMS
JAK familija	JAK1 • JAK2 • JAK3 • TYK2
SRC-A familija	SRC • FGR • FYN • YES1
SRC-B familija	BLK • HCK • LCK • LYN
TEC familija	TEC • BMX • BTK • ITK • TXK
SYK familija	SYK • ZAP70

B enzm:1.1/2/3/4/5/6/7/8/10/11/13/14/15-18,2.1/2/3/4/5/6/7/8,2.7.10,2.7.11-12,3.1/2/3/4/5/6/7,3.1.3.48,3.4.21/22/23/24,4.1/2/3/4/5/6,5.1/2/3/4/99,6.1-3/4/5-6

p r u Proteini:klasteri diferencijacije (vidi istospisak ljudskih klastera diferencijacije)
1-50	CD1 (a-c,1A,1D,1E) • CD2 • CD3 (γ,δ,ε) • CD4 • CD5 • CD6 • CD7 • CD8 (a) • CD9 • CD10 • CD11 (a,b,c) • CD13 • CD14 • CD15 • CD16 (A,B) • CD18 • CD19 • CD20 • CD21 • CD22 • CD23 • CD24 • CD25 • CD26 • CD27 • CD28 • CD29 • CD30 • CD31 • CD32 (A,B) • CD33 • CD34 • CD35 • CD36 • CD37 • CD38 • CD39 • CD40 • CD41 • CD42 (a,b,c,d) • CD43 • CD44 • CD45 • CD46 • CD47 • CD48 • CD49 (a,b,c,d,e,f) • CD50
51-100	CD51 • CD52 • CD53 • CD54 • CD55 • CD56 • CD57 • CD58 • CD59 • CD61 • CD62 (E,L,P) • CD63 • CD64 (A,B,C) • CD66 (a,b,c,d,e,f) • CD68 • CD69 • CD70 • CD71 • CD72 • CD73 • CD74 • CD78 • CD79 (a,b) • CD80 • CD81 • CD82 • CD83 • CD84 • CD85 (a,d,e,h,j,k) • CD86 • CD87 • CD88 • CD89 • CD90 • CD91-CD92 • CD93 • CD94 • CD95 • CD96 • CD97 • CD98 • CD99 • CD100
101-150	CD101 • CD102 • CD103 • CD104 • CD105 • CD106 • CD107 (a,b) • CD108 • CD109 • CD110 • CD111 • CD112 • CD113 • CD114 • CD115 • CD116 • CD117 • CD118 • CD119 • CD120 (a,b) • CD121 (a,b) • CD122 • CD123 • CD124 • CD125 • CD126 • CD127 • CD129 • CD130 • CD131 • CD132 • CD133 • CD134 • CD135 • CD136 • CD137 • CD138 • CD140b • CD141 • CD142 • CD143 • CD144 • CD146 • CD147 • CD148 • CD150
151-200	CD151 • CD152 • CD153 • CD154 • CD155 • CD156 (a,b,c) • CD157 • CD158 (a,d,e,i,k) • CD159 (a,c) • CD160 • CD161 • CD162 • CD163 • CD164 • CD166 • CD167 (a,b) • CD168 • CD169 • CD170 • CD171 • CD172 (a,b,g) • CD174 • CD177 • CD178 • CD179 (a,b) • CD181 • CD182 • CD183 • CD184 • CD185 • CD186 • CD191 • CD192 • CD193 • CD194 • CD195 • CD196 • CD197 • CDw198 • CDw199 • CD200
201-250	CD201 • CD202b • CD204 • CD205 • CD206 • CD207 • CD208 • CD209 • CDw210 (a,b) • CD212 • CD213a (1,2) • CD217 • CD218 (a,b) • CD220 • CD221 • CD222 • CD223 • CD224 • CD225 • CD226 • CD227 • CD228 • CD229 • CD230 • CD233 • CD234 • CD235 (a,b) • CD236 • CD238 • CD239 • CD240CE • CD241 • CD243 • CD244 • CD246 • CD247-CD248 • CD249
251-300	CD252 • CD253 • CD254 • CD256 • CD257 • CD258 • CD261 • CD262 • CD264 • CD265 • CD266 • CD267 • CD268 • CD269 • CD271 • CD272 • CD273 • CD274 • CD275 • CD276 • CD278 • CD279 • CD280 • CD281 • CD282 • CD283 • CD284 • CD286 • CD288 • CD289 • CD290 • CD292 • CDw293 • CD294 • CD295 • CD297 • CD298 • CD299
301-350	CD300A • CD301 • CD302 • CD303 • CD304 • CD305 • CD306 • CD307 • CD309 • CD312 • CD314 • CD315 • CD316 • CD317 • CD318 • CD320 • CD321 • CD322 • CD324 • CD325 • CD326 • CD328 • CD329 • CD331 • CD332 • CD333 • CD334 • CD335 • CD336 • CD337 • CD338 • CD339 • CD340 • CD344 • CD349 • CD350

p r u Proteini:enzimi
Teme	Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
Tipovi	EC1Oksidoreduktaze/spisak • EC2Transferaze/spisak • EC3Hidrolaze/spisak • EC4Lijaze/spisak • EC5Izomeraze/spisak • EC6Ligaze/spisak
B enzm:1.1/2/3/4/5/6/7/8/10/11/13/14/15-18,2.1/2/3/4/5/6/7/8,2.7.10,2.7.11-12,3.1/2/3/4/5/6/7,3.1.3.48,3.4.21/22/23/24,4.1/2/3/4/5/6,5.1/2/3/4/99,6.1-3/4/5-6

Izvor:https://sh.wikipedia.org/w/index.php?title=DDR1&oldid=42509473

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