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Cisteinil leukotrienski receptor 1

Uredi veze

Izvor: Wikipedija

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Cisteinil leukotrienski receptor 1

Identifikatori

Simboli

CYSLTR1; CYSLT1; CYSLT1R; CYSLTR; HG55; HMTMF81

Vanjski ID

OMIM: 300201MGI: 1926218HomoloGene: 4837IUPHAR:CysLT₁GeneCards:CYSLTR1 Gene

Ontologija gena
Molekularna funkcija	•aktivnost prenosa signala•receptorska aktivnost•aktivnost leukotrienskog receptora
Celularna komponenta	•membranska frakcija•ćelijska membrana•integralno sa ćelijskom membranom
Biološki proces	•transport kalcijumskih jona•hemotaksa•odbrambeni respons•inflamatorni respons•povišenje koncentracije citozolinih kalcijumovih jona•razmena respiratornih gasova•pozitivna regulacija vazokonstrikcije

Ortolozi

Vrsta

Čovek

Miš

RefSeq (mRNA)

RefSeq (protein)

Lokacija (UCSC)

Chr X:
77.53 - 77.58 Mb

Chr X:
103.77 - 103.8 Mb

PubMed pretraga

[1]

[2]

Cisteinil leukotrienski receptor 1 jeprotein koji je kod ljudi kodiranCYSLTR1genom.^[1]^[2]^[3]

Cisteinilleukotrieni LTC4,LTD4 iLTE4 su posrednici ljudskebronhijalne astme. Farmakološke studije su utvrdile da cisteinil leukotrieni aktiviraju najmanje 2 receptora, protein kodiran ovim genom iCYSLTR2. Ovaj receptor je član superfamilijeG protein spregnutih receptora. Aktivacija ovog receptora LTD4 ligandom dovodi kontrakcija i proliferacijeglatkih mišića,eozinofilne migracije i oštećenja sluznog slojapluća.^[3]

Reference

[uredi |uredi kod]

↑Lynch KR, O'Neill GP, Liu Q, Im DS, Sawyer N, Metters KM, Coulombe N, Abramovitz M, Figueroa DJ, Zeng Z, Connolly BM, Bai C, Austin CP, Chateauneuf A, Stocco R, Greig GM, Kargman S, Hooks SB, Hosfield E, Williams DL Jr, Ford-Hutchinson AW, Caskey CT, Evans JF (Jul 1999). „Characterization of the human cysteinyl leukotriene CysLT1 receptor”. Nature 399 (6738): 789–93. DOI:10.1038/21658. PMID 10391245.
↑Sarau HM, Ames RS, Chambers J, Ellis C, Elshourbagy N, Foley JJ, Schmidt DB, Muccitelli RM, Jenkins O, Murdock PR, Herrity NC, Halsey W, Sathe G, Muir AI, Nuthulaganti P, Dytko GM, Buckley PT, Wilson S, Bergsma DJ, Hay DW (Sep 1999). „Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor”. Mol Pharmacol 56 (3): 657–63. PMID 10462554.
↑^3,0^3,1„Entrez Gene: CYSLTR1 cysteinyl leukotriene receptor 1”.

Literatura

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Gronert K, Martinsson-Niskanen T, Ravasi S,et al. (2001). „Selectivity of recombinant human leukotriene D(4), leukotriene B(4), and lipoxin A(4) receptors with aspirin-triggered 15-epi-LXA(4) and regulation of vascular and inflammatory responses.”. Am. J. Pathol. 158 (1): 3–9. DOI:10.1016/S0002-9440(10)63937-5. PMC 1850279. PMID 11141472.
Sjöström M, Jakobsson PJ, Heimburger M,et al. (2001). „Human umbilical vein endothelial cells generate leukotriene C4 via microsomal glutathione S-transferase type 2 and express the CysLT(1) receptor.”. Eur. J. Biochem. 268 (9): 2578–86. DOI:10.1046/j.1432-1327.2001.02142.x. PMID 11322876.
Mellor EA, Maekawa A, Austen KF, Boyce JA (2001). „Cysteinyl leukotriene receptor 1 is also a pyrimidinergic receptor and is expressed by human mast cells.”. Proc. Natl. Acad. Sci. U.S.A. 98 (14): 7964–9. DOI:10.1073/pnas.141221498. PMC 35451. PMID 11438743.
Mita H, Hasegawa M, Saito H, Akiyama K (2002). „Levels of cysteinyl leukotriene receptor mRNA in human peripheral leucocytes: significantly higher expression of cysteinyl leukotriene receptor 2 mRNA in eosinophils.”. Clin. Exp. Allergy 31 (11): 1714–23. DOI:10.1046/j.1365-2222.2001.01184.x. PMID 11696047.
Shirasaki H, Kanaizumi E, Watanabe K,et al. (2003). „Expression and localization of the cysteinyl leukotriene 1 receptor in human nasal mucosa.”. Clin. Exp. Allergy 32 (7): 1007–12. DOI:10.1046/j.1365-2222.2002.01425.x. PMID 12100046.
Ohshima N, Nagase H, Koshino T,et al. (2002). „A functional study on CysLT(1) receptors in human eosinophils.”. Int. Arch. Allergy Immunol. 129 (1): 67–75. DOI:10.1159/000065175. PMID 12373000.
Strausberg RL, Feingold EA, Grouse LH,et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ohd JF, Nielsen CK, Campbell J,et al. (2003). „Expression of the leukotriene D4 receptor CysLT1, COX-2, and other cell survival factors in colorectal adenocarcinomas.”. Gastroenterology 124 (1): 57–70. DOI:10.1053/gast.2003.50011. PMID 12512030.
Chibana K, Ishii Y, Asakura T, Fukuda T (2003). „Up-regulation of cysteinyl leukotriene 1 receptor by IL-13 enables human lung fibroblasts to respond to leukotriene C4 and produce eotaxin.”. J. Immunol. 170 (8): 4290–5. PMID 12682264.
Espinosa K, Bossé Y, Stankova J, Rola-Pleszczynski M (2003). „CysLT1 receptor upregulation by TGF-beta and IL-13 is associated with bronchial smooth muscle cell proliferation in response to LTD4.”. J. Allergy Clin. Immunol. 111 (5): 1032–40. DOI:10.1067/mai.2003.1451. PMID 12743568.
Walch L, Norel X, Gascard JP, Brink C (2003). „Arachidonic acid inhibits cysteinyl-leukotriene receptor activation in human pulmonary vessels.”. Adv. Exp. Med. Biol. 525: 75–9. PMID 12751740.
Nielsen CK, Ohd JF, Wikström K,et al. (2003). „The leukotriene receptor CysLT1 and 5-lipoxygenase are upregulated in colon cancer.”. Adv. Exp. Med. Biol. 525: 201–4. PMID 12751768.
Mechiche H, Naline E, Candenas L,et al. (2003). „Effects of cysteinyl leukotrienes in small human bronchus and antagonist activity of montelukast and its metabolites.”. Clin. Exp. Allergy 33 (7): 887–94. DOI:10.1046/j.1365-2222.2003.01696.x. PMID 12859443.
Ota T, Suzuki Y, Nishikawa T,et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs.”. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039.
Yang G, Haczku A, Chen H,et al. (2004). „Transgenic smooth muscle expression of the human CysLT1 receptor induces enhanced responsiveness of murine airways to leukotriene D4.”. Am. J. Physiol. Lung Cell Mol. Physiol. 286 (5): L992–1001. DOI:10.1152/ajplung.00367.2003. PMID 15064240.
Gerhard DS, Wagner L, Feingold EA,et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Naik S, Billington CK, Pascual RM,et al. (2005). „Regulation of cysteinyl leukotriene type 1 receptor internalization and signaling.”. J. Biol. Chem. 280 (10): 8722–32. DOI:10.1074/jbc.M413014200. PMID 15590629.
Corrigan C, Mallett K, Ying S,et al. (2005). „Expression of the cysteinyl leukotriene receptors cysLT(1) and cysLT(2) in aspirin-sensitive and aspirin-tolerant chronic rhinosinusitis.”. J. Allergy Clin. Immunol. 115 (2): 316–22. DOI:10.1016/j.jaci.2004.10.051. PMID 15696087.

Vanjske veze

[uredi |uredi kod]

„Leukotriene Receptors: CysLT₁”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano izoriginala na datum 2016-03-03.

Povezano

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Eikozanoidni receptor

Transmembranski receptor:G protein spregnuti receptori

Klasa A:Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A,B,D) • α2 (A,B,C) • β1 • β2 • β3
Purinski	Adenozinski (A1,A2A,A2B,A3) • P2Y (1,2,4,5,6,8,9,10,11,12,13,14)
Serotoninski	(svi osim 5-HT3)5-HT1 (A,B,D,E,F) • 5-HT2 (A,B,C) • 5-HT (4,5A,6,7)
Drugi	Acetilholin (M1,M2,M3,M4,M5) • Dopamin (D1,D2,D3,D4,D5) • Histamin (H1,H2,H3,H4) • Melatonin (1A,1B,1C) • TAAR (1,2,3,5,6,8,9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1,2) • LTB4 (1,2) • FPRL1 • OXE • Prostaglandin (DP (1,2),EP (1,2,3,4),FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1,CB2,GPR (18,55,119)) • EBI2 • Estrogen • Slobodna masna kiselina (1,2,3,4) • Laktat • Lizofosfatidna kiselina (1,2,3,4,5,6) • Lizofosfolipid (1,2,3,4,5,6,7,8) • Niacin (1,2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1,2,3,4,5) • Sukcinat

Peptid

Neuropeptidni

B/W (1,2) • FF (1,2) • S • Y (1,2,4,5) • Neuromedin (B,U (1,2)) • Neurotenzin (1,2)

Drugi

Anafilatoksin (C3a,C5a) • Angiotenzin (1,2) • Apelin • Bombezin (BRS3,GRPR,NMBR) • Bradikinin (B1,B2) • Hemokin • Holecistokinin (A,B) • Endotelin (A,B) • Formil peptid (1,2,3) • FSH • Galanin (1,2,3) • GHB receptor • Gonadotropin-oslobađajući hormon (1,2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1,1L,D,E,F,G,X1,X2,X3,X4) • Melanokortin (1,2,3,4,5) • MCHR (1,2) • Motilin • Opioidni (δ,κ,μ,Nociceptin &ζ, ali neσ) • Oreksin (1,2) • Oksitocin • Prokineticin (1,2) • Prolaktin-oslobađajući peptid • Relaksin (1,2,3,4) • Somatostatin (1,2,3,4,5) • Tahikinin (1,2,3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A,1B,2)

Razno

Orfan	GPR (1,3,4,6,12,15,17,18,19,20,21,22,23,25,26,27,31,32,33,34,35,37,39,42,44,45,50,52,55,61,62,63,65,68,75,77,78,81,82,83,84,85,87,88,92,101,103,109A,109B,119,120,132,135,137B,139,141,142,146,148,149,150,151,152,153,160,161,162,171,173,174,176,177,182,183)
Drugi	Adrenomedulin • Mirisni • Opsin (3,4,5,1LW,1MW,1SW,RGR,RRH) • Proteazom-aktivirani (1,2,3,4) • SREB (1,2,3)

Klasa B:Sekretinu slični

Orfan

GPR (56,64,97,98,110,111,112,113,114,115,116,123,124,125,126,128,133,143,144,155,157)

Drugi

Moždano specifični angiogenezni inhibitor (1,2,3) • Cadherin (1,2,3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1,2) • EMR (1,2,3) • Glukagon (GR,GIPR,GLP1R,GLP2R) • Hormon rasta oslobađajući hormon • PACAPR1 • GPR • Latrofilin (1,2,3,ELTD1) • Metuselah-slični proteini • Paratiroidni hormon (1,2) • Sekretin • Vazoaktivni intestinalni peptid (1,2)

Klasa C:Metabotropni
glutamat /feromon

Ukus	TAS1R (1,2,3) • TAS2R (1,3,4,5,8,9,10,12,13,14,16,19,20,30,31,38,39,40,41,42,43,45,46,50)
Drugi	Kalcijum-detektujući receptor • GABA B (1,2) • Glutamatni receptor (Metabotropni glutamat (1,2,3,4,5,6,7,8)) • GPRC6A • GPR (156,158,179) • RAIG (1,2,3,4)

Klasa F:
Frizzled /Zaglađeni

Uvojiti	Frizzled (1,2,3,4,5,6,7,8,9,10)
Zaglađeni	Zaglađeni

B trdu:peptidi (nrpl/grfl/cytl/horl),receptori (lgic,enzr,gprc,igsr,intg,nrpr/grfr/cytr),itra (adap,gbpr,mapk),calc,lipd, signalni putevi (hedp,wntp,tgfp+mapp,notp,jakp,fsap,hipp,tlrp)

Izvor:https://sh.wikipedia.org/w/index.php?title=Cisteinil_leukotrienski_receptor_1&oldid=42507504

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