CCL19,hemokin (C-C motiv) ligand 19, jeprotein koji je kod ljudi kodiranCCL19genom.[1][2] CCL19 ja malicitokin iz CChemokin familije koji je takođe poznat kaoEBI1 ligand hemokin (ELC) imakrofagni inflamatorni protein-3-beta (MIP-3-beta).[3]
Ovajgen je jedan od nekoliko CC citokinskih gena grupisanih na p-rucihromozoma 9[4] Ovaj hemokin dejstvuje na svoje ciljne ćelije vezivanjem zahemokinski receptorCCR7.[5].Citokini su familija izlučenih proteina koji učestvuju u imunoregulatornim i inflamatornim procesima. CC citokini suproteini karakterisani sa dva susednacisteina. Za citokin kodiran ovim genom se veruje da igra ulogu u normalnoj recirkulacijilimfocita. On takođe ima važnu ulogu u razmeniT ćelija utimusu, i u migraciji T ćelija i B ćelija u sekundarne limfoidne organe. On se specifično vezuje za hemokinski receptorCCR7.[2]
CCL19 je obilno izražen utimusu ilimfnim čvorovima, u umerenim nivoima utraheji ikolonu, i u niskim nivoima u stomaku,tankim crevima,plućima,bubrezima islezini.[5] On privlači određene ćelijeimunskog sistema, kao što sudendritske ćelije i antigen-aktiviraneB ćelije,[6][7]CCR7+ efektorske-memorijske T-ćelije.[8]
- ↑Yoshida R, Imai T, Hieshima K, Kusuda J, Baba M, Kitaura M, Nishimura M, Kakizaki M, Nomiyama H, Yoshie O (Jul 1997). „Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7”. J Biol Chem 272 (21): 13803–9. DOI:10.1074/jbc.272.21.13803. PMID 9153236.
- ↑2,02,1„Entrez Gene: CCL19 chemokine (C-C motif) ligand 19”.
- ↑Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.
- ↑Rossi DL, Vicari AP, Franz-Bacon K, McClanahan TK, Zlotnik A (1997). „Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta”. J. Immunol. 158 (3): 1033–6. PMID 9013939.
- ↑5,05,1Yoshida R, Imai T, Hieshima K, Kusuda J, Baba M, Kitaura M, Nishimura M, Kakizaki M, Nomiyama H, Yoshie O (1997). „Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7”. J. Biol. Chem. 272 (21): 13803–9. DOI:10.1074/jbc.272.21.13803. PMID 9153236.
- ↑Robbiani DF, Finch RA, Jäger D, Muller WA, Sartorelli AC, Randolph GJ (2000). „The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes”. Cell 103 (5): 757–68. DOI:10.1016/S0092-8674(00)00179-3. PMID 11114332.
- ↑Reif K, Ekland EH, Ohl L, Nakano H, Lipp M, Förster R, Cyster JG (2002). „Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position”. Nature 416 (6876): 94–9. DOI:10.1038/416094a. PMID 11882900.
- ↑Bromley SK, Thomas SY, Luster AD (2005). „Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics”. Nat. Immunol. 6 (9): 895–901. DOI:10.1038/ni1240. PMID 16116469.
- Weber C, Koenen RR (2006). „Fine-tuning leukocyte responses: towards a chemokine 'interactome'.”. Trends Immunol. 27 (6): 268–73. DOI:10.1016/j.it.2006.04.002. PMID 16678487.
- Rossi DL, Vicari AP, Franz-Bacon K,et al. (1997). „Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta.”. J. Immunol. 158 (3): 1033–6. PMID 9013939.
- Nagira M, Imai T, Hieshima K,et al. (1997). „Molecular cloning of a novel human CC chemokine secondary lymphoid-tissue chemokine that is a potent chemoattractant for lymphocytes and mapped to chromosome 9p13.”. J. Biol. Chem. 272 (31): 19518–24. DOI:10.1074/jbc.272.31.19518. PMID 9235955.
- Kim CH, Pelus LM, White JR,et al. (1998). „CK beta-11/macrophage inflammatory protein-3 beta/EBI1-ligand chemokine is an efficacious chemoattractant for T and B cells.”. J. Immunol. 160 (5): 2418–24. PMID 9498785.
- Yanagihara S, Komura E, Nagafune J,et al. (1998). „EBI1/CCR7 is a new member of dendritic cell chemokine receptor that is up-regulated upon maturation.”. J. Immunol. 161 (6): 3096–102. PMID 9743376.
- Gosling J, Dairaghi DJ, Wang Y,et al. (2000). „Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK.”. J. Immunol. 164 (6): 2851–6. PMID 10706668.
- Annunziato F, Romagnani P, Cosmi L,et al. (2000). „Macrophage-derived chemokine and EBI1-ligand chemokine attract human thymocytes in different stage of development and are produced by distinct subsets of medullary epithelial cells: possible implications for negative selection.”. J. Immunol. 165 (1): 238–46. PMID 10861057.
- Ueno T, Hara K, Willis MS,et al. (2002). „Role for CCR7 ligands in the emigration of newly generated T lymphocytes from the neonatal thymus.”. Immunity 16 (2): 205–18. DOI:10.1016/S1074-7613(02)00267-4. PMID 11869682.
- Phillips R, Ager A (2002). „Activation of pertussis toxin-sensitive CXCL12 (SDF-1) receptors mediates transendothelial migration of T lymphocytes across lymph node high endothelial cells.”. Eur. J. Immunol. 32 (3): 837–47. DOI:10.1002/1521-4141(200203)32:3<837::AID-IMMU837>3.0.CO;2-Q. PMID 11870628.
- Till KJ, Lin K, Zuzel M, Cawley JC (2002). „The chemokine receptor CCR7 and alpha4 integrin are important for migration of chronic lymphocytic leukemia cells into lymph nodes.”. Blood 99 (8): 2977–84. DOI:10.1182/blood.V99.8.2977. PMID 11929789.
- Townson JR, Nibbs RJ (2002). „Characterization of mouse CCX-CKR, a receptor for the lymphocyte-attracting chemokines TECK/mCCL25, SLC/mCCL21 and MIP-3beta/mCCL19: comparison to human CCX-CKR.”. Eur. J. Immunol. 32 (5): 1230–41. DOI:10.1002/1521-4141(200205)32:5<1230::AID-IMMU1230>3.0.CO;2-L. PMID 11981810.
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- Katou F, Ohtani H, Nakayama T,et al. (2003). „Differential expression of CCL19 by DC-Lamp+ mature dendritic cells in human lymph node versus chronically inflamed skin.”. J. Pathol. 199 (1): 98–106. DOI:10.1002/path.1255. PMID 12474232.
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- Corcione A, Arduino N, Ferretti E,et al. (2004). „CCL19 and CXCL12 trigger in vitro chemotaxis of human mantle cell lymphoma B cells.”. Clin. Cancer Res. 10 (3): 964–71. DOI:10.1158/1078-0432.CCR-1182-3. PMID 14871974.
- Daikoku N, Kitaya K, Nakayama T,et al. (2004). „Expression of macrophage inflammatory protein-3beta in human endometrium throughout the menstrual cycle.”. Fertil. Steril. 81 Suppl 1: 876–81. DOI:10.1016/j.fertnstert.2003.09.036. PMID 15019823.
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