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C5a receptor

Uredi veze

Izvor: Wikipedija

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Receptor 1 komplementne komponente 5a

Identifikatori

Simboli

C5AR1; C5A; C5AR; C5R1; CD88

Vanjski ID

OMIM: 113995MGI: 88232HomoloGene: 20413IUPHAR:C5aGeneCards:C5AR1 Gene

Ontologija gena
Molekularna funkcija	•aktivnost rodopsinu-sličnog receptora•receptorska aktivnost•aktivnost C5a anafilatoksinskog receptora
Celularna komponenta	•ćelijska membrana•integralno sa ćelijskom membranom
Biološki proces	•aktivacija MAPK aktivnosti•hemotaksa•imunski respons•ćelijski odbrambeni respons•prenos signal•signalni put G-protein spregnutog receptora•aktivacija fosfolipaze C•elevacija koncentracije jona citosolnog kalcijuma•senzorna percepcija hemijskog stimulusa

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

RefSeq (mRNA)

RefSeq (protein)

Lokacija (UCSC)

Chr 19:
52.5 - 52.52 Mb

Chr 7:
15.41 - 15.42 Mb

PubMed pretraga

[1]

[2]

C5a receptor (receptor 1 komplementne komponente 5a,C5AR1,CD88,klaster diferencijacije 88) jeG protein spregnuti receptor zaC5a. On funkcioniše kaokomplementni receptor.^[1]

Ćelije

[uredi |uredi kod]

C5a receptor je izražen na:^[2]

Granulociti
Monociti
Dendritske ćelije
Ćelijska linija izvedena iz hepatoma,HepG2
Astrociti
Mikroglija

Povezano

[uredi |uredi kod]

Komponenta komplementa 5a

Literatura

[uredi |uredi kod]

↑Gerard C, Gerard NP (1994). „C5A anaphylatoxin and its seven transmembrane-segment receptor”. Annu. Rev. Immunol. 12: 775–808. DOI:10.1146/annurev.iy.12.040194.004015. PMID 8011297.
↑„PROW and IWHLDA: CD88”. Arhivirano izoriginala na datum 2008-07-24. Pristupljeno 2014-05-08.

Dodatna literatura

[uredi |uredi kod]

Sengeløv H (1996). „Complement receptors in neutrophils.”. Crit. Rev. Immunol. 15 (2): 107–31. PMID 8573284.
Beil WJ, Schulz M, Wefelmeyer U (2001). „Mast cell granule composition and tissue location--a close correlation.”. Histol. Histopathol. 15 (3): 937–46. PMID 10963136.
Yamamoto T (2007). „Roles of the ribosomal protein S19 dimer and the C5a receptor in pathophysiological functions of phagocytic leukocytes.”. Pathol. Int. 57 (1): 1–11. DOI:10.1111/j.1440-1827.2007.02049.x. PMID 17199736.
Bao L, Gerard NP, Eddy RL,et al. (1992). „Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19.”. Genomics 13 (2): 437–40. DOI:10.1016/0888-7543(92)90265-T. PMID 1612600.
Gerard NP, Gerard C (1991). „The chemotactic receptor for human C5a anaphylatoxin.”. Nature 349 (6310): 614–7. DOI:10.1038/349614a0. PMID 1847994.
Boulay F, Mery L, Tardif M,et al. (1991). „Expression cloning of a receptor for C5a anaphylatoxin on differentiated HL-60 cells.”. Biochemistry 30 (12): 2993–9. DOI:10.1021/bi00226a002. PMID 2007135.
Wahl SM, Allen JB, Gartner S,et al. (1989). „HIV-1 and its envelope glycoprotein down-regulate chemotactic ligand receptors and chemotactic function of peripheral blood monocytes.”. J. Immunol. 142 (10): 3553–9. PMID 2541200.
Foreman KE, Vaporciyan AA, Bonish BK,et al. (1994). „C5a-induced expression of P-selectin in endothelial cells.”. J. Clin. Invest. 94 (3): 1147–55. DOI:10.1172/JCI117430. PMC 295185. PMID 7521884.
Giannini E, Brouchon L, Boulay F (1995). „Identification of the major phosphorylation sites in human C5a anaphylatoxin receptor in vivo.”. J. Biol. Chem. 270 (32): 19166–72. DOI:10.1074/jbc.270.32.19166. PMID 7642584.
Buhl AM, Osawa S, Johnson GL (1995). „Mitogen-activated protein kinase activation requires two signal inputs from the human anaphylatoxin C5a receptor.”. J. Biol. Chem. 270 (34): 19828–32. DOI:10.1074/jbc.270.34.19828. PMID 7649993.
Wennogle LP, Conder L, Winter C,et al. (1994). „Stabilization of C5a receptor--G-protein interactions through ligand binding.”. J. Cell. Biochem. 55 (3): 380–8. DOI:10.1002/jcb.240550316. PMID 7962171.
Gerard NP, Bao L, Xiao-Ping H,et al. (1993). „Human chemotaxis receptor genes cluster at 19q13.3-13.4. Characterization of the human C5a receptor gene.”. Biochemistry 32 (5): 1243–50. DOI:10.1021/bi00056a007. PMID 8383526.
Ames RS, Li Y, Sarau HM,et al. (1996). „Molecular cloning and characterization of the human anaphylatoxin C3a receptor.”. J. Biol. Chem. 271 (34): 20231–4. DOI:10.1074/jbc.271.34.20231. PMID 8702752.
Werfel T, Zwirner J, Oppermann M,et al. (1996). „CD88 antibodies specifically bind to C5aR on dermal CD117+ and CD14+ cells and react with a desmosomal antigen in human skin.”. J. Immunol. 157 (4): 1729–35. PMID 8759762.
Höpken UE, Lu B, Gerard NP, Gerard C (1996). „The C5a chemoattractant receptor mediates mucosal defence to infection.”. Nature 383 (6595): 86–9. DOI:10.1038/383086a0. PMID 8779720.
Chen Z, Zhang X, Gonnella NC,et al. (1998). „Residues 21-30 within the extracellular N-terminal region of the C5a receptor represent a binding domain for the C5a anaphylatoxin.”. J. Biol. Chem. 273 (17): 10411–9. DOI:10.1074/jbc.273.17.10411. PMID 9553099.
Floreani AA, Heires AJ, Welniak LA,et al. (1998). „Expression of receptors for C5a anaphylatoxin (CD88) on human bronchial epithelial cells: enhancement of C5a-mediated release of IL-8 upon exposure to cigarette smoke.”. J. Immunol. 160 (10): 5073–81. PMID 9590258.
Ottonello L, Corcione A, Tortolina G,et al. (1999). „rC5a directs the in vitro migration of human memory and naive tonsillar B lymphocytes: implications for B cell trafficking in secondary lymphoid tissues.”. J. Immunol. 162 (11): 6510–7. PMID 10352266.
Kohleisen B, Shumay E, Sutter G,et al. (2000). „Stable expression of HIV-1 Nef induces changes in growth properties and activation state of human astrocytes.”. AIDS 13 (17): 2331–41. DOI:10.1097/00002030-199912030-00004. PMID 10597774.
Monk PN, Scola A-M, Madala P, Fairlie DP (2007). „Function, structure and therapeutic potential of complement C5a receptors”. British Journal of Pharmacology 152 (4): 429–48. DOI:10.1038/sj.bjp.0707332. PMC 2050825. PMID 17603557.

Vanjske veze

[uredi |uredi kod]

„Anaphylatoxin Receptors: C5a”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano izoriginala na datum 2014-04-07.
MeSHC5a+receptors

p r u Proteini:klasteri diferencijacije (vidi istospisak ljudskih klastera diferencijacije)
1-50	CD1 (a-c,1A,1D,1E) • CD2 • CD3 (γ,δ,ε) • CD4 • CD5 • CD6 • CD7 • CD8 (a) • CD9 • CD10 • CD11 (a,b,c) • CD13 • CD14 • CD15 • CD16 (A,B) • CD18 • CD19 • CD20 • CD21 • CD22 • CD23 • CD24 • CD25 • CD26 • CD27 • CD28 • CD29 • CD30 • CD31 • CD32 (A,B) • CD33 • CD34 • CD35 • CD36 • CD37 • CD38 • CD39 • CD40 • CD41 • CD42 (a,b,c,d) • CD43 • CD44 • CD45 • CD46 • CD47 • CD48 • CD49 (a,b,c,d,e,f) • CD50
51-100	CD51 • CD52 • CD53 • CD54 • CD55 • CD56 • CD57 • CD58 • CD59 • CD61 • CD62 (E,L,P) • CD63 • CD64 (A,B,C) • CD66 (a,b,c,d,e,f) • CD68 • CD69 • CD70 • CD71 • CD72 • CD73 • CD74 • CD78 • CD79 (a,b) • CD80 • CD81 • CD82 • CD83 • CD84 • CD85 (a,d,e,h,j,k) • CD86 • CD87 • CD88 • CD89 • CD90 • CD91-CD92 • CD93 • CD94 • CD95 • CD96 • CD97 • CD98 • CD99 • CD100
101-150	CD101 • CD102 • CD103 • CD104 • CD105 • CD106 • CD107 (a,b) • CD108 • CD109 • CD110 • CD111 • CD112 • CD113 • CD114 • CD115 • CD116 • CD117 • CD118 • CD119 • CD120 (a,b) • CD121 (a,b) • CD122 • CD123 • CD124 • CD125 • CD126 • CD127 • CD129 • CD130 • CD131 • CD132 • CD133 • CD134 • CD135 • CD136 • CD137 • CD138 • CD140b • CD141 • CD142 • CD143 • CD144 • CD146 • CD147 • CD148 • CD150
151-200	CD151 • CD152 • CD153 • CD154 • CD155 • CD156 (a,b,c) • CD157 • CD158 (a,d,e,i,k) • CD159 (a,c) • CD160 • CD161 • CD162 • CD163 • CD164 • CD166 • CD167 (a,b) • CD168 • CD169 • CD170 • CD171 • CD172 (a,b,g) • CD174 • CD177 • CD178 • CD179 (a,b) • CD181 • CD182 • CD183 • CD184 • CD185 • CD186 • CD191 • CD192 • CD193 • CD194 • CD195 • CD196 • CD197 • CDw198 • CDw199 • CD200
201-250	CD201 • CD202b • CD204 • CD205 • CD206 • CD207 • CD208 • CD209 • CDw210 (a,b) • CD212 • CD213a (1,2) • CD217 • CD218 (a,b) • CD220 • CD221 • CD222 • CD223 • CD224 • CD225 • CD226 • CD227 • CD228 • CD229 • CD230 • CD233 • CD234 • CD235 (a,b) • CD236 • CD238 • CD239 • CD240CE • CD241 • CD243 • CD244 • CD246 • CD247-CD248 • CD249
251-300	CD252 • CD253 • CD254 • CD256 • CD257 • CD258 • CD261 • CD262 • CD264 • CD265 • CD266 • CD267 • CD268 • CD269 • CD271 • CD272 • CD273 • CD274 • CD275 • CD276 • CD278 • CD279 • CD280 • CD281 • CD282 • CD283 • CD284 • CD286 • CD288 • CD289 • CD290 • CD292 • CDw293 • CD294 • CD295 • CD297 • CD298 • CD299
301-350	CD300A • CD301 • CD302 • CD303 • CD304 • CD305 • CD306 • CD307 • CD309 • CD312 • CD314 • CD315 • CD316 • CD317 • CD318 • CD320 • CD321 • CD322 • CD324 • CD325 • CD326 • CD328 • CD329 • CD331 • CD332 • CD333 • CD334 • CD335 • CD336 • CD337 • CD338 • CD339 • CD340 • CD344 • CD349 • CD350

Proteini:Sistem komplementa (C,L,A)

Aktivatori/enzimi

Rano	C:C1Q/C1R/C1S -C4 (C4a) -C2 L:MASP1/MASP2 -MBL A:Faktor B -Faktor D -Faktor P/Properdin
Srednje	C3 (C3a,C3b/iC3b) -C5 (C5a) C3-konvertaza -C5-konvertaza
Kasno	MAC (C6,C7,C8,C9)

Inhibitori

CLA:C1-inhibitor -Faktor ubrzanja raspada/CD59 -Faktor I

CL:C4BP

A:Faktor H

Receptori komplementa

CR1 -CR2 -CR3 -CR4 -CD11b/CD11c/CD18 -Anafilatoksin (C3a,C5a)

M:LMC

ćelije/fis/auag/auab

imdf/ipig/hyps/tumr

proc, lek (L3/4)

Transmembranski receptor:G protein spregnuti receptori

Klasa A:Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A,B,D) • α2 (A,B,C) • β1 • β2 • β3
Purinski	Adenozinski (A1,A2A,A2B,A3) • P2Y (1,2,4,5,6,8,9,10,11,12,13,14)
Serotoninski	(svi osim 5-HT3)5-HT1 (A,B,D,E,F) • 5-HT2 (A,B,C) • 5-HT (4,5A,6,7)
Drugi	Acetilholin (M1,M2,M3,M4,M5) • Dopamin (D1,D2,D3,D4,D5) • Histamin (H1,H2,H3,H4) • Melatonin (1A,1B,1C) • TAAR (1,2,3,5,6,8,9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1,2) • LTB4 (1,2) • FPRL1 • OXE • Prostaglandin (DP (1,2),EP (1,2,3,4),FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1,CB2,GPR (18,55,119)) • EBI2 • Estrogen • Slobodna masna kiselina (1,2,3,4) • Laktat • Lizofosfatidna kiselina (1,2,3,4,5,6) • Lizofosfolipid (1,2,3,4,5,6,7,8) • Niacin (1,2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1,2,3,4,5) • Sukcinat

Peptid

Neuropeptidni

B/W (1,2) • FF (1,2) • S • Y (1,2,4,5) • Neuromedin (B,U (1,2)) • Neurotenzin (1,2)

Drugi

Anafilatoksin (C3a,C5a) • Angiotenzin (1,2) • Apelin • Bombezin (BRS3,GRPR,NMBR) • Bradikinin (B1,B2) • Hemokin • Holecistokinin (A,B) • Endotelin (A,B) • Formil peptid (1,2,3) • FSH • Galanin (1,2,3) • GHB receptor • Gonadotropin-oslobađajući hormon (1,2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1,1L,D,E,F,G,X1,X2,X3,X4) • Melanokortin (1,2,3,4,5) • MCHR (1,2) • Motilin • Opioidni (δ,κ,μ,Nociceptin &ζ, ali neσ) • Oreksin (1,2) • Oksitocin • Prokineticin (1,2) • Prolaktin-oslobađajući peptid • Relaksin (1,2,3,4) • Somatostatin (1,2,3,4,5) • Tahikinin (1,2,3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A,1B,2)

Razno

Orfan	GPR (1,3,4,6,12,15,17,18,19,20,21,22,23,25,26,27,31,32,33,34,35,37,39,42,44,45,50,52,55,61,62,63,65,68,75,77,78,81,82,83,84,85,87,88,92,101,103,109A,109B,119,120,132,135,137B,139,141,142,146,148,149,150,151,152,153,160,161,162,171,173,174,176,177,182,183)
Drugi	Adrenomedulin • Mirisni • Opsin (3,4,5,1LW,1MW,1SW,RGR,RRH) • Proteazom-aktivirani (1,2,3,4) • SREB (1,2,3)

Klasa B:Sekretinu slični

Orfan

GPR (56,64,97,98,110,111,112,113,114,115,116,123,124,125,126,128,133,143,144,155,157)

Drugi

Moždano specifični angiogenezni inhibitor (1,2,3) • Cadherin (1,2,3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1,2) • EMR (1,2,3) • Glukagon (GR,GIPR,GLP1R,GLP2R) • Hormon rasta oslobađajući hormon • PACAPR1 • GPR • Latrofilin (1,2,3,ELTD1) • Metuselah-slični proteini • Paratiroidni hormon (1,2) • Sekretin • Vazoaktivni intestinalni peptid (1,2)

Klasa C:Metabotropni
glutamat /feromon

Ukus	TAS1R (1,2,3) • TAS2R (1,3,4,5,8,9,10,12,13,14,16,19,20,30,31,38,39,40,41,42,43,45,46,50)
Drugi	Kalcijum-detektujući receptor • GABA B (1,2) • Glutamatni receptor (Metabotropni glutamat (1,2,3,4,5,6,7,8)) • GPRC6A • GPR (156,158,179) • RAIG (1,2,3,4)

Klasa F:
Frizzled /Zaglađeni

Uvojiti	Frizzled (1,2,3,4,5,6,7,8,9,10)
Zaglađeni	Zaglađeni

B trdu:peptidi (nrpl/grfl/cytl/horl),receptori (lgic,enzr,gprc,igsr,intg,nrpr/grfr/cytr),itra (adap,gbpr,mapk),calc,lipd, signalni putevi (hedp,wntp,tgfp+mapp,notp,jakp,fsap,hipp,tlrp)

Izvor:https://sh.wikipedia.org/w/index.php?title=C5a_receptor&oldid=42506205

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