Movatterモバイル変換

[0]ホーム

Prijeđi na sadržaj

C3a receptor

Uredi veze

Izvor: Wikipedija

edit

Receptor 1 komplementne komponente 3a

Identifikatori

Simboli

C3AR1; AZ3B; C3AR; HNFAG09

Vanjski ID

OMIM: 605246MGI: 1097680HomoloGene: 2992IUPHAR:C3aGeneCards:C3AR1 Gene

Ontologija gena
Molekularna funkcija	•aktivnost rodopsinu-sličnog receptora•aktivnost fosfoinozitid fosfolipaze C•receptorska aktivnost•aktivnost receptora komplementne komponente 3a•aktivnost C3a anafilatoksinskog receptora
Celularna komponenta	•ćelijska membrana•integralno sa ćelijskom membranom
Biološki proces	•ćelijska motilnost•hemotaksa•kontrakcija glatkog mišića•inflamatorni respons•ćelijski odbrambeni respons•prenos signala•signalni put G-protein spregnutog receptora•elevacija koncentracije jona citosolnog kalcijuma•cirkulacija

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

RefSeq (mRNA)

RefSeq (protein)

Lokacija (UCSC)

Chr 12:
8.1 - 8.11 Mb

Chr 6:
122.81 - 122.82 Mb

PubMed pretraga

[1]

[2]

C3a receptor (receptor 1 komplementne komponente 3a,C3AR1) jeG protein-spregnuti receptor koji je deosistema komplementa.^[1]^[2]

Ligandi ovog receptora suC3a iC4a.

Literatura

[uredi |uredi kod]

↑Roglic A, Prossnitz ER, Cavanagh SL, Pan Z, Zou A, Ye RD (1996). „cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure”. Biochim. Biophys. Acta 1305 (1–2): 39–43. PMID 8605247.
↑Ali H, Panettieri RA (2005). „Anaphylatoxin C3a receptors in asthma”. Respir. Res. 6: 19. DOI:10.1186/1465-9921-6-19. PMC 551592. PMID 15723703.

Dodatna literatura

[uredi |uredi kod]

Sim RB, Laich A (2001). „Serine proteases of the complement system”. Biochem. Soc. Trans. 28 (5): 545–50. PMID 11044372.
Maruyama K, Sugano S (1994). „Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides”. Gene 138 (1–2): 171–4. DOI:10.1016/0378-1119(94)90802-8. PMID 8125298.
Roglic A, Prossnitz ER, Cavanagh SL,et al. (1996). „cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure”. Biochim. Biophys. Acta 1305 (1–2): 39–43. PMID 8605247.
Ames RS, Li Y, Sarau HM,et al. (1996). „Molecular cloning and characterization of the human anaphylatoxin C3a receptor”. J. Biol. Chem. 271 (34): 20231–4. DOI:10.1074/jbc.271.34.20231. PMID 8702752.
Crass T, Raffetseder U, Martin U,et al. (1996). „Expression cloning of the human C3a anaphylatoxin receptor (C3aR) from differentiated U-937 cells”. Eur. J. Immunol. 26 (8): 1944–50. DOI:10.1002/eji.1830260840. PMID 8765043.
Ames RS, Nuthulaganti P, Kumar C (1996). „In Xenopus oocytes the human C3a and C5a receptors elicit a promiscuous response to the anaphylatoxins”. FEBS Lett. 395 (2–3): 157–9. DOI:10.1016/0014-5793(96)01018-6. PMID 8898085.
Martin U, Bock D, Arseniev L,et al. (1997). „The human C3a receptor is expressed on neutrophils and monocytes, but not on B or T lymphocytes”. J. Exp. Med. 186 (2): 199–207. DOI:10.1084/jem.186.2.199. PMC 2198980. PMID 9221749.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K,et al. (1997). „Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library”. Gene 200 (1–2): 149–56. DOI:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hollmann TJ, Haviland DL, Kildsgaard J,et al. (1998). „Cloning, expression, sequence determination, and chromosome localization of the mouse complement C3a anaphylatoxin receptor gene”. Mol. Immunol. 35 (3): 137–48. DOI:10.1016/S0161-5890(98)00021-2. PMID 9694514.
Lienenklaus S, Ames RS, Tornetta MA,et al. (1998). „Human anaphylatoxin C4a is a potent agonist of the guinea pig but not the human C3a receptor”. J. Immunol. 161 (5): 2089–93. PMID 9725198.
Davoust N, Jones J, Stahel PF,et al. (1999). „Receptor for the C3a anaphylatoxin is expressed by neurons and glial cells”. Glia 26 (3): 201–11. DOI:10.1002/(SICI)1098-1136(199905)26:3<201::AID-GLIA2>3.0.CO;2-M. PMID 10340761.
Settmacher B, Bock D, Saad H,et al. (1999). „Modulation of C3a activity: internalization of the human C3a receptor and its inhibition by C5a”. J. Immunol. 162 (12): 7409–16. PMID 10358194.
Feild JA, Foley JJ, Testa TT,et al. (1999). „Cloning and characterization of a rabbit ortholog of human Galpha16 and mouse G(alpha)15”. FEBS Lett. 460 (1): 53–6. DOI:10.1016/S0014-5793(99)01317-4. PMID 10571060.
Petering H, Köhl J, Weyergraf A,et al. (2000). „Characterization of synthetic C3a analog peptides on human eosinophils in comparison to the native complement component C3a”. J. Immunol. 164 (7): 3783–9. PMID 10725738.
Drouin SM, Kildsgaard J, Haviland J,et al. (2001). „Expression of the complement anaphylatoxin C3a and C5a receptors on bronchial epithelial and smooth muscle cells in models of sepsis and asthma”. J. Immunol. 166 (3): 2025–32. PMID 11160252.
Ames RS, Lee D, Foley JJ,et al. (2001). „Identification of a selective nonpeptide antagonist of the anaphylatoxin C3a receptor that demonstrates antiinflammatory activity in animal models”. J. Immunol. 166 (10): 6341–8. PMID 11342658.
Kirchhoff K, Weinmann O, Zwirner J,et al. (2001). „Detection of anaphylatoxin receptors on CD83+ dendritic cells derived from human skin”. Immunology 103 (2): 210–7. DOI:10.1046/j.1365-2567.2001.01197.x. PMC 1783227. PMID 11412308.
Strausberg RL, Feingold EA, Grouse LH,et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Reca R, Mastellos D, Majka M,et al. (2003). „Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells, and C3a enhances their homing-related responses to SDF-1”. Blood 101 (10): 3784–93. DOI:10.1182/blood-2002-10-3233. PMID 12511407.

Vanjske veze

[uredi |uredi kod]

„Anaphylatoxin Receptors: C3a”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano izoriginala na datum 2016-03-03.
MeSHC3AR1+protein,+human

Proteini:Sistem komplementa (C,L,A)

Aktivatori/enzimi

Rano	C:C1Q/C1R/C1S -C4 (C4a) -C2 L:MASP1/MASP2 -MBL A:Faktor B -Faktor D -Faktor P/Properdin
Srednje	C3 (C3a,C3b/iC3b) -C5 (C5a) C3-konvertaza -C5-konvertaza
Kasno	MAC (C6,C7,C8,C9)

Inhibitori

CLA:C1-inhibitor -Faktor ubrzanja raspada/CD59 -Faktor I

CL:C4BP

A:Faktor H

Receptori komplementa

CR1 -CR2 -CR3 -CR4 -CD11b/CD11c/CD18 -Anafilatoksin (C3a,C5a)

M:LMC

ćelije/fis/auag/auab

imdf/ipig/hyps/tumr

proc, lek (L3/4)

Transmembranski receptor:G protein spregnuti receptori

Klasa A:Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A,B,D) • α2 (A,B,C) • β1 • β2 • β3
Purinski	Adenozinski (A1,A2A,A2B,A3) • P2Y (1,2,4,5,6,8,9,10,11,12,13,14)
Serotoninski	(svi osim 5-HT3)5-HT1 (A,B,D,E,F) • 5-HT2 (A,B,C) • 5-HT (4,5A,6,7)
Drugi	Acetilholin (M1,M2,M3,M4,M5) • Dopamin (D1,D2,D3,D4,D5) • Histamin (H1,H2,H3,H4) • Melatonin (1A,1B,1C) • TAAR (1,2,3,5,6,8,9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1,2) • LTB4 (1,2) • FPRL1 • OXE • Prostaglandin (DP (1,2),EP (1,2,3,4),FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1,CB2,GPR (18,55,119)) • EBI2 • Estrogen • Slobodna masna kiselina (1,2,3,4) • Laktat • Lizofosfatidna kiselina (1,2,3,4,5,6) • Lizofosfolipid (1,2,3,4,5,6,7,8) • Niacin (1,2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1,2,3,4,5) • Sukcinat

Peptid

Neuropeptidni

B/W (1,2) • FF (1,2) • S • Y (1,2,4,5) • Neuromedin (B,U (1,2)) • Neurotenzin (1,2)

Drugi

Anafilatoksin (C3a,C5a) • Angiotenzin (1,2) • Apelin • Bombezin (BRS3,GRPR,NMBR) • Bradikinin (B1,B2) • Hemokin • Holecistokinin (A,B) • Endotelin (A,B) • Formil peptid (1,2,3) • FSH • Galanin (1,2,3) • GHB receptor • Gonadotropin-oslobađajući hormon (1,2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1,1L,D,E,F,G,X1,X2,X3,X4) • Melanokortin (1,2,3,4,5) • MCHR (1,2) • Motilin • Opioidni (δ,κ,μ,Nociceptin &ζ, ali neσ) • Oreksin (1,2) • Oksitocin • Prokineticin (1,2) • Prolaktin-oslobađajući peptid • Relaksin (1,2,3,4) • Somatostatin (1,2,3,4,5) • Tahikinin (1,2,3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A,1B,2)

Razno

Orfan	GPR (1,3,4,6,12,15,17,18,19,20,21,22,23,25,26,27,31,32,33,34,35,37,39,42,44,45,50,52,55,61,62,63,65,68,75,77,78,81,82,83,84,85,87,88,92,101,103,109A,109B,119,120,132,135,137B,139,141,142,146,148,149,150,151,152,153,160,161,162,171,173,174,176,177,182,183)
Drugi	Adrenomedulin • Mirisni • Opsin (3,4,5,1LW,1MW,1SW,RGR,RRH) • Proteazom-aktivirani (1,2,3,4) • SREB (1,2,3)

Klasa B:Sekretinu slični

Orfan

GPR (56,64,97,98,110,111,112,113,114,115,116,123,124,125,126,128,133,143,144,155,157)

Drugi

Moždano specifični angiogenezni inhibitor (1,2,3) • Cadherin (1,2,3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1,2) • EMR (1,2,3) • Glukagon (GR,GIPR,GLP1R,GLP2R) • Hormon rasta oslobađajući hormon • PACAPR1 • GPR • Latrofilin (1,2,3,ELTD1) • Metuselah-slični proteini • Paratiroidni hormon (1,2) • Sekretin • Vazoaktivni intestinalni peptid (1,2)

Klasa C:Metabotropni
glutamat /feromon

Ukus	TAS1R (1,2,3) • TAS2R (1,3,4,5,8,9,10,12,13,14,16,19,20,30,31,38,39,40,41,42,43,45,46,50)
Drugi	Kalcijum-detektujući receptor • GABA B (1,2) • Glutamatni receptor (Metabotropni glutamat (1,2,3,4,5,6,7,8)) • GPRC6A • GPR (156,158,179) • RAIG (1,2,3,4)

Klasa F:
Frizzled /Zaglađeni

Uvojiti	Frizzled (1,2,3,4,5,6,7,8,9,10)
Zaglađeni	Zaglađeni

B trdu:peptidi (nrpl/grfl/cytl/horl),receptori (lgic,enzr,gprc,igsr,intg,nrpr/grfr/cytr),itra (adap,gbpr,mapk),calc,lipd, signalni putevi (hedp,wntp,tgfp+mapp,notp,jakp,fsap,hipp,tlrp)

Izvor:https://sh.wikipedia.org/w/index.php?title=C3a_receptor&oldid=42507342

Kategorije:

[8]ページ先頭