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Alfa-2B adrenergički receptor

Uredi veze

Izvor: Wikipedija

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Adrenergički alfa-2B receptor

Identifikatori

Simboli

ADRA2B; ADRA2L1; ADRA2RL1; ADRARL1; ALPHA2BAR

Vanjski ID

OMIM: 104260MGI: 87935HomoloGene: 553IUPHAR:α_2B-adrenoceptorGeneCards:ADRA2B Gene

Ontologija gena
Molekularna funkcija	•aktivnost rodopsinu-sličnog receptora•receptorska aktivnost•adrenoceptorska aktivnost•aktivnost alfa2-adrenergičkog receptora
Celularna komponenta	•ćelijska membrana•integralno sa ćelijskom membranom
Biološki proces	•prenos signala•signalni put G-protein spregnutog receptora•interćelijska signalizacija

Ortolozi

Vrsta

Čovek

Miš

n/a

RefSeq (mRNA)

RefSeq (protein)

Lokacija (UCSC)

n/a

Chr 2:
127.05 - 127.06 Mb

PubMed pretraga

[1]

[2]

Alfa-2B adrenergički receptor (α_2B adrenoceptor) jeG-protein spregnuti receptor. On je tipadrenergičke receptorske familije. Humanigen koji kodira ovaj receptor ima simbolADRA2B.^[1]ADRA2Bortolozi^[2] su identifikovani kod nekolikosisara.

Receptor

[uredi |uredi kod]

Postoje tri visoko homologna tipa alfa-2-adrenergičkog receptora: alfa_2A, alfa_2B, i alfa_2C. Ti receptori učestvuju u regulaciji otpuštanjaneurotransmitera izsimpatičkih nerva i iz adrenergičkih neuronacentralnog nervnog sistema.

Gen

[uredi |uredi kod]

Ovaj gen kodira alfa_2B tip receptora. On se vezuje zaeIF-2B,faktor razmene guanin nukleotida koji učestvuje u regulacijitranslacije. Za polimorfnu varijantu alfa_2B tip, kojoj nedostaju 3glutaminske kiseline iz elementa ponavljanja glutaminskih kiselina, je ustanoljeno da ima umanjenuGPCR kinazama-posredovanufosforilaciju idesenzitizaciju. Ova polimorfna forma je isto tako povezana sa umanjenombazalnim metabolizmom kodgojaznih osoba i moguće je da doprinosi patogenezi gojaznosti. Ovaj gen ne sadržiintrone.^[1]

Selektivni ligandi

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Antagonisti

[uredi |uredi kod]

Povezano

[uredi |uredi kod]

Adrenergički receptor

Reference

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Literatura

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Lomasney JW, Lorenz W, Allen LF,et al. (1990). „Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2.”. Proc. Natl. Acad. Sci. U.S.A. 87 (13): 5094–8. DOI:10.1073/pnas.87.13.5094. PMC 54268. PMID 2164221.
McClue SJ, Milligan G (1990). „The alpha 2B adrenergic receptor of undifferentiated neuroblastoma x glioma hybrid NG108-15 cells, interacts directly with the guanine nucleotide binding protein, Gi2.”. FEBS Lett. 269 (2): 430–4. DOI:10.1016/0014-5793(90)81209-7. PMID 2169434.
Weinshank RL, Zgombick JM, Macchi M,et al. (1990). „Cloning, expression, and pharmacological characterization of a human alpha 2B-adrenergic receptor.”. Mol. Pharmacol. 38 (5): 681–8. PMID 2172775.
Chang AC, Ho TF, Chang NC (1990). „In vitro amplification by polymerase chain reaction of a partial gene encoding the third subtype of alpha-2 adrenergic receptor in humans.”. Biochem. Biophys. Res. Commun. 172 (2): 817–23. DOI:10.1016/0006-291X(90)90748-C. PMID 2173582.
Regan JW, Kobilka TS, Yang-Feng TL,et al. (1988). „Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype.”. Proc. Natl. Acad. Sci. U.S.A. 85 (17): 6301–5. DOI:10.1073/pnas.85.17.6301. PMC 281957. PMID 2842764.
Petrash AC, Bylund DB (1986). „Alpha-2 adrenergic receptor subtypes indicated by [3H]yohimbine binding in human brain.”. Life Sci. 38 (23): 2129–37. DOI:10.1016/0024-3205(86)90212-2. PMID 3012234.
Klein U, Ramirez MT, Kobilka BK, von Zastrow M (1997). „A novel interaction between adrenergic receptors and the alpha-subunit of eukaryotic initiation factor 2B.”. J. Biol. Chem. 272 (31): 19099–102. DOI:10.1074/jbc.272.31.19099. PMID 9235896.
Okusa MD, Huang L, Momose-Hotokezaka A,et al. (1998). „Regulation of adenylyl cyclase in polarized renal epithelial cells by G protein-coupled receptors.”. Am. J. Physiol. 273 (6 Pt 2): F883–91. PMID 9435676.
Prezeau L, Richman JG, Edwards SW, Limbird LE (1999). „The zeta isoform of 14-3-3 proteins interacts with the third intracellular loop of different alpha2-adrenergic receptor subtypes.”. J. Biol. Chem. 274 (19): 13462–9. DOI:10.1074/jbc.274.19.13462. PMID 10224112.
Heinonen P, Koulu M, Pesonen U,et al. (1999). „Identification of a three-amino acid deletion in the alpha2B-adrenergic receptor that is associated with reduced basal metabolic rate in obese subjects.”. J. Clin. Endocrinol. Metab. 84 (7): 2429–33. DOI:10.1210/jc.84.7.2429. PMID 10404816.
Hein L, Altman JD, Kobilka BK (2000). „Two functionally distinct alpha2-adrenergic receptors regulate sympathetic neurotransmission.”. Nature 402 (6758): 181–4. DOI:10.1038/46040. PMID 10647009.
Small KM, Brown KM, Forbes SL, Liggett SB (2001). „Polymorphic deletion of three intracellular acidic residues of the alpha 2B-adrenergic receptor decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization.”. J. Biol. Chem. 276 (7): 4917–22. DOI:10.1074/jbc.M008118200. PMID 11056163.
Snapir A, Mikkelsson J, Perola M,et al. (2003). „Variation in the alpha2B-adrenoceptor gene as a risk factor for prehospital fatal myocardial infarction and sudden cardiac death.”. J. Am. Coll. Cardiol. 41 (2): 190–4. DOI:10.1016/S0735-1097(02)02702-X. PMID 12535806.
Sykiotis GP, Polyzogopoulou E, Georgopoulos NA,et al. (2004). „The alpha2B adrenergic receptor deletion/insertion polymorphism in morbid obesity.”. Clin. Auton. Res. 13 (3): 203–7. DOI:10.1007/s10286-003-0087-5. PMID 12822042.
Chotani MA, Mitra S, Su BY,et al. (2004). „Regulation of alpha(2)-adrenoceptors in human vascular smooth muscle cells.”. Am. J. Physiol. Heart Circ. Physiol. 286 (1): H59–67. DOI:10.1152/ajpheart.00268.2003. PMID 12946937.
Von Wowern F, Bengtsson K, Lindblad U,et al. (2004). „Functional variant in the (alpha)2B adrenoceptor gene, a positional candidate on chromosome 2, associates with hypertension.”. Hypertension 43 (3): 592–7. DOI:10.1161/01.HYP.0000116224.51189.80. PMID 14744925.
Cayla C, Heinonen P, Viikari L,et al. (2004). „Cloning, characterisation and identification of several polymorphisms in the promoter region of the human alpha2B-adrenergic receptor gene.”. Biochem. Pharmacol. 67 (3): 469–78. DOI:10.1016/j.bcp.2003.09.029. PMID 15037199.
Phares DA, Halverstadt AA, Shuldiner AR,et al. (2004). „Association between body fat response to exercise training and multilocus ADR genotypes.”. Obes. Res. 12 (5): 807–15. DOI:10.1038/oby.2004.97. PMID 15166301.
Siitonen N, Lindström J, Eriksson J,et al. (2005). „Association between a deletion/insertion polymorphism in the alpha2B-adrenergic receptor gene and insulin secretion and Type 2 diabetes. The Finnish Diabetes Prevention Study.”. Diabetologia 47 (8): 1416–24. DOI:10.1007/s00125-004-1462-z. PMID 15309292.
Belfer I, Buzas B, Hipp H,et al. (2005). „Haplotype-based analysis of alpha 2A, 2B, and 2C adrenergic receptor genes captures information on common functional loci at each gene.”. J. Hum. Genet. 50 (1): 12–20. DOI:10.1007/s10038-004-0211-y. PMID 15592690.

Vanjske veze

[uredi |uredi kod]

„α_2B-adrenoceptor”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano izoriginala na datum 2016-03-05.

Transmembranski receptor:G protein spregnuti receptori

Klasa A:Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A,B,D) • α2 (A,B,C) • β1 • β2 • β3
Purinski	Adenozinski (A1,A2A,A2B,A3) • P2Y (1,2,4,5,6,8,9,10,11,12,13,14)
Serotoninski	(svi osim 5-HT3)5-HT1 (A,B,D,E,F) • 5-HT2 (A,B,C) • 5-HT (4,5A,6,7)
Drugi	Acetilholin (M1,M2,M3,M4,M5) • Dopamin (D1,D2,D3,D4,D5) • Histamin (H1,H2,H3,H4) • Melatonin (1A,1B,1C) • TAAR (1,2,3,5,6,8,9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1,2) • LTB4 (1,2) • FPRL1 • OXE • Prostaglandin (DP (1,2),EP (1,2,3,4),FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1,CB2,GPR (18,55,119)) • EBI2 • Estrogen • Slobodna masna kiselina (1,2,3,4) • Laktat • Lizofosfatidna kiselina (1,2,3,4,5,6) • Lizofosfolipid (1,2,3,4,5,6,7,8) • Niacin (1,2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1,2,3,4,5) • Sukcinat

Peptid

Neuropeptidni

B/W (1,2) • FF (1,2) • S • Y (1,2,4,5) • Neuromedin (B,U (1,2)) • Neurotenzin (1,2)

Drugi

Anafilatoksin (C3a,C5a) • Angiotenzin (1,2) • Apelin • Bombezin (BRS3,GRPR,NMBR) • Bradikinin (B1,B2) • Hemokin • Holecistokinin (A,B) • Endotelin (A,B) • Formil peptid (1,2,3) • FSH • Galanin (1,2,3) • GHB receptor • Gonadotropin-oslobađajući hormon (1,2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1,1L,D,E,F,G,X1,X2,X3,X4) • Melanokortin (1,2,3,4,5) • MCHR (1,2) • Motilin • Opioidni (δ,κ,μ,Nociceptin &ζ, ali neσ) • Oreksin (1,2) • Oksitocin • Prokineticin (1,2) • Prolaktin-oslobađajući peptid • Relaksin (1,2,3,4) • Somatostatin (1,2,3,4,5) • Tahikinin (1,2,3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A,1B,2)

Razno

Orfan	GPR (1,3,4,6,12,15,17,18,19,20,21,22,23,25,26,27,31,32,33,34,35,37,39,42,44,45,50,52,55,61,62,63,65,68,75,77,78,81,82,83,84,85,87,88,92,101,103,109A,109B,119,120,132,135,137B,139,141,142,146,148,149,150,151,152,153,160,161,162,171,173,174,176,177,182,183)
Drugi	Adrenomedulin • Mirisni • Opsin (3,4,5,1LW,1MW,1SW,RGR,RRH) • Proteazom-aktivirani (1,2,3,4) • SREB (1,2,3)

Klasa B:Sekretinu slični

Orfan

GPR (56,64,97,98,110,111,112,113,114,115,116,123,124,125,126,128,133,143,144,155,157)

Drugi

Moždano specifični angiogenezni inhibitor (1,2,3) • Cadherin (1,2,3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1,2) • EMR (1,2,3) • Glukagon (GR,GIPR,GLP1R,GLP2R) • Hormon rasta oslobađajući hormon • PACAPR1 • GPR • Latrofilin (1,2,3,ELTD1) • Metuselah-slični proteini • Paratiroidni hormon (1,2) • Sekretin • Vazoaktivni intestinalni peptid (1,2)

Klasa C:Metabotropni
glutamat /feromon

Ukus	TAS1R (1,2,3) • TAS2R (1,3,4,5,8,9,10,12,13,14,16,19,20,30,31,38,39,40,41,42,43,45,46,50)
Drugi	Kalcijum-detektujući receptor • GABA B (1,2) • Glutamatni receptor (Metabotropni glutamat (1,2,3,4,5,6,7,8)) • GPRC6A • GPR (156,158,179) • RAIG (1,2,3,4)

Klasa F:
Frizzled /Zaglađeni

Uvojiti	Frizzled (1,2,3,4,5,6,7,8,9,10)
Zaglađeni	Zaglađeni

B trdu:peptidi (nrpl/grfl/cytl/horl),receptori (lgic,enzr,gprc,igsr,intg,nrpr/grfr/cytr),itra (adap,gbpr,mapk),calc,lipd, signalni putevi (hedp,wntp,tgfp+mapp,notp,jakp,fsap,hipp,tlrp)

Adrenergici

Ligandi receptora

α₁	Agonisti:5-FNE •6-FNE •Amidefrin •Anisodamin •Anisodin •Cirazolin •Dipivefrin •Dopamin •Efedrin •Epinefrin (Adrenalin) •Etilefrin •Etilnorepinefrin •Indanidin •Levonordefrin •Metaraminol •Metoksamin •Metildopa •Midodrin •Nafazolin •Norepinefrin (Noradrenalin) •Oktopamin •Oksimetazolin •Fenilefrin •Fenilpropanolamin •Pseudoefedrin •Sinefrin •Tetrahidrozolin Antagonisti:Abanohil •Adimolol •Ajmalicin •Alfuzosin •Amosulalol •Arotinolol •Atiprosin •Benoksatian •Buflomedil •Bunazosin •Karvedilol •CI-926 •Korinantin •Dapiprazol •DL-017 •Domesticin •Doksazosin •Eugenodilol •Fenspirid •GYKI-12,743 •GYKI-16,084 •Indoramin •Ketanserin •L-765,314 •Labetalol •Mefendioksan •Metazosin •Monatepil •Moksisilit (Timoksamin) •Naftopidil •Nantenin •Neldazosin •Nicergolin •Niguldipin •Pelanserin •Fendioksan •Fenoksibenzamin •Fentolamin •Piperoksan •Prazosin •Hinazosin •Ritanserin •RS-97,078 •SGB-1,534 •Silodosin •SL-89.0591 •Spiperon •Talipeksol •Tamsulosin •Terazosin •Tibalosin •Tiodazosin •Tipentosin •Tolazolin •Trimazosin •Upidosin •Urapidil •Zolertin * MnogiTCA,TeCA,antipsihotici,ergolini, i nekipiperazini kao što subuspiron,trazodon,nefazodon,etoperidon, imepiprazol takođe antagoniziraju α₁-adrenergičke receptore, što doprinosi njihovim nuspojavama.
α₂	Agonisti:(R)-3-Nitrobifenilin •4-NEMD •6-FNE •Amitraz •Apraklonidin •Brimonidin •Kanabivarin •Klonidin •Detomidin •Deksmedetomidin •Dihodroergotamin •Dipivefrin •Dopamin •Efedrin •Ergotamin •Epinefrin (Adrenalin) •Esprohin •Etilefrin •Etilnorepinefrin •Gvanabenz •Gvanfacin •Gvanoksabenz •Levonordefrin •Lofeksidin •Medetomidin •Metildopa •Mivazerol •Nafazolin •Norepinefrin (Noradrenalin) •Fenilpropanolamin •Piperoksan •Pseudoefedrin •Rilmenidin •Romifidin •Talipeksol •Tetrahidrozolin •Tizanidin •Tolonidin •Urapidil •Ksilazin •Ksilometazolin Antagonisti:1-PP •Adimolol •Aptazapin •Atipamezol •BRL-44408 •Buflomedil •Cirazolin •Efaroksan •Esmirtazapin •Fenmetozol •Fluparoksan •GYKI-12,743 •GYKI-16,084 •Idazoksan •Mianserin •Mirtazapin •MK-912 •NAN-190 •Olanzapin •Fentolamin •Fenoksibenzamin •Piperoksan •Piribedil •Rauvolscin •Rotigotin •SB-269,970 •Setiptilin •Spiroksatrin •Sunepitron •Tolazolin •Johimbin * Mnogiatipični antipsihotici iazapironi poputbuspirona igepirona (putem metabolita1-PP) takođe antagonizuju α₂-adrenergičke receptore.
β	Agonisti:2-FNE •5-FNE •Amibegron •Arbutamin •Arformoterol •Arotinolol •BAAM •Bambuterol •Befunolol •Bitolterol •Broksaterol •Bufenin •Karbuterol •Cimaterol •Klenbuterol •Denopamin •Deterenol •Dipivefrin •Dobutamin •Dopamin •Dopeksamin •Efedrin •Epinefrin (Adrenalin) •Etafedrin •Etilefrin •Etilnorepinefrin •Fenoterol •Formoterol •Heksoprenalin •Higenamin •Indakaterol •Izoetarin •Izoprenalin (Itoproterenol) •Izoksuprin •Labetalol •Levonordefrin •Levosalbutamol •Mabuterol •Metoksifenamin •Metildopa •N-Izopropuloktopamin •Norepinefrin (Noradrenalin) •Orciprenalin •Oksifedrin •Fenilpropanolamin •Pirbuterol •Prenalterol •Raktopamin •Prokaterol •Pseudoefedrin •Reproterol •Rimiterol •Ritodrin •Salbutamol (Albuterol) •Salmeterol •Solabegron •Terbutalin •Tretohuinol •Tulobuterol •Ksamoterol •Zilpaterol •Zinterol Antagonisti:Acebutolol •Adaprolol •Adimolol •Afurolol •Alprenolol •Alprenoksim •Amosulalol •Ankarolol •Arnolol •Arotinolol •Atenolol •Befunolol •Betaksolol •Bevantolol •Bisoprolol •Bopindolol •Bormetolol •Bornaprolol •Brefonalol •Bucindolol •Bucumolol •Bufetolol •Buftiralol •Bufuralol •Bunitrolol •Bunolol •Bupranolol •Burocrolol •Butaksamin •Butidrin •Butofilolol •Kapsinolol •Karazolol •Karpindolol •Karteolol •Karvedilol •Celiprolol •Ketamolol •Cikloprolol •Cinamolol •Cloranolol •Cianopindolol •Dalbraminol •Dekspropranolol •Diacetolol •Dihloroizoprenalin •Dihidroalprenolol •Dilevalol •Diprafenon •Drahinolol •Dropranolol •Ekastolol •Epanolol •Erikolol •Ersentilid •Esatenolol •Esmolol •Esprolol •Eugenodilol •Eksaprolol •Falintolol •Flestolol •Flusoksolol •Hidroksikarteolol •Hidroksitertatolol •ICI-118,551 •Idropranolol •Indenolol •Indopanolol •Jodocijanopindolol •Iprokrolol •Izoksaprolol •Izamoltan •Labetalol •Landiolol •Levobetaksolol •Levobunolol •Levocikloprolol •Levomoprolol •Medroksalol •Mepindolol •Metalol •Metipranolol •Metoprolol •Moprolol •Nadolol •Nadoksolol •Nafetolol •Nebivolol •Neraminol •Nifenalol •Nipradilol •Oberadilol •Oksprenolol •Pakrinolol •Pafenolol •Pamatolol •Pargolol •Parodilol •Penbutolol •Penirolol •PhQA-33 •Pindolol •Pirepolol •Practolol •Primidolol •Procinolol •Pronetalol •Propafenon •Propranolol •Ridazolol •Ronaktolol •Sohinolol •Sotalol •Spirendolol •SR 59230A •Sulfinalol •TA-2005 •Talinolol •Tazolol •Teoprolol •Tertatolol •Tertianolol •Tienoksolol •Tilisolol •Timolol •Tiprenolol •Tolamolol •Toliprolol •Tribendilol •Trigevolol •Ksibenolol •Ksipranolol

Inhibitori preuzimanja

NET

Selektivni inhibitori preuzimanja norepinefrina:Amedalin •Atomoksetin (Tomoksetin) •Ciklazindol •Daledalin •Esreboksetin •Lortalamin •Mazindol •Nisoksetin •Reboksetin •Talopram •Talsupram •Tandamin •Viloksazin;Inhibitori preuzimanja norepinefrina-dopamina:Amineptin •Bupropion (Amfebutamon) •Fenkamin •Fencamfamin •Lefetamin •Levofacetoperan •LR-5182 •Manifaksin •Metilfenidat •Nomifensin •O-2172 •Radafaksin;Inhibitori preuzimanja serotonina-norepinefrina:Bicifadin •Desvenlafaksin •Duloksetin •Eklanamin •Levomilnacipran •Milnacipran •Sibutramin •Venlafaksin;Inhibitori preuzimanja serotonina-norepinefrina-dopamina:Brasofensin •Diklofensin •DOV-102,677 •DOV-21,947 •DOV-216,303 •JNJ-7925476 •JZ-IV-10 •Metilnaftidat •Nafiron •NS-2359 •PRC200-SS •SEP-225,289 •SEP-227,162 •Tesofensin;Triciklični antidepresanti:Amitriptilin •Butriptilin •Cianopramin •Clomipramin •Desipramin •Dosulepin •Doksepin •Imipramin •Lofepramin •melitracen •Nortriptilin •Protriptilin •Trimipramin;Tetraciklični antidepresanti:Amoksapin •Maprotilin •Mianserin •Oksaprotilin •Setiptilin;Drugi:Kokain •CP-39,332 •EXP-561 •Fezolamin •Nefazodon •Nefopam •Pridefrin •Tapentadol •Tramadol •Ziprasidon

VMAT

Ibogain •Reserpin •Tetrabenazin

Agensi otpuštanja

Morfolini:Fenbutrazat •Morazon •Fendimetrazin •Fenmetrazin;Oksazolini:4-Metilaminoreks •Aminoreks •Klominoreks •Ciklazodon •Fenozolon •Fluminoreks •Pemolin •Tozalinon;Fenetilamini (takođeamfetamini,katinoni,fentermini, etc):2-OH-PEA •4-CAB •4-FA •4-FMA •4-MA •4-MMA •Alfetamin •Amfehloral •Amfepentoreks •Amfepramon •Amfetamin (Dekstroamfetamin,Levoamfetamin) •Amfetaminil •β-Me-PEA •BDB •Benzfetamin •BOH •Bufedron •Butilon •Katin •Katinon •Hlobenzoreks •Hlortermin •D-Deprenil •Dimetilamfetamin •Dimetilkatinon (Dimetilpropion, metamfepramon) •DMA •DMMA •EBDB •Efedrin •Etkatinon •Etilamfetamin •Etilon •Famprofazon •Fenetilin •Fenproporeks •Flefedron •Fludoreks •Furfenoreks •Hordenin •IAP •IMP •L-Deprenil (Selegilin) •Lisdeksamfetamin •Lofofin •MBDB •MDA (Tenamfetamin) •MDEA •MDMA •MDMPEA •MDOH •MDPEA •Mefenoreks •Mefedron •Mefentermin •Metamfetamin (Dekstrometamfetamin,Levometamftamin) •Metkatinon •Metedron •Metilon •NAP •Ortetamin •Paredrin •pBA •pCA •Pentoreks (Fenpentermin) •Fenetilamin •Foledrin •Fenprometamin •Fentermin •Fenilpropanolamin •pIA •Prenilamin •Propilamfetamin •Pseudoefedrin •Tifloreks •Tiramin •Ksilopropamin •Zilofuramin;Piperazini:2C-B-BZP •BZP •MBZP •mCPP •MDBZP •MeOPP •pFPP;Drugi:2-Amino-1,2-dihidronaftalen •2-Aminoindan •2-Aminotetralin •2-Benzilpiperidin •4-Benzilpiperidin •5-IAI •Hlofenciklan •Ciklopentamin •Cipenamin •Ciprodenat •Feprosidnin •Gilutensin •Heptaminol •Heksaciklonat •Indanoreks •Izometepten •Metilheksanamin •Oktodrin •Ftalimidopropiofenon •Propilheksedrin (Levopropilheksedrin) •Tuaminoheptan

Inhibitori enzima

Anabolizam

PAH	3,4-Dihidroksistiren
TH	3-Jodotirozin •Akvuajamicin •Bulbokapnin •Metirozin •Oudenon
AAAD	Benzerazid •Karbidopa •Genistein •Metildopa
DBH	Bupikomid •Disulfiram •Dopastin •Fusarična kiselina •Nepikastat •fenopikolinska kiselina •Tropolon
PNMT	CGS-19281A •SKF-64139 •SKF-7698

Katabolizam

MAO

Neselektivni:Benmoksin •Karoksazon •Ehinopsidin •Furazolidon •Hidralazin •Indantadol •Iproklozid •Iproniazid •Izokarboksazid •Izoniazid •Linezolid •Mebanazin •Metfendrazin •Nialamid •Oktamoksin •Paraksazon •Fenelzin •Feniprazin •fenoksipropazin •Pivalilbenzhidrazin •Prokarbazin •Safrazin •Tranilcipromin;MAO-A selektivni:Amiflamin •Bazinaprin •Befloksaton •Befol •Brofaromin •Cimoksaton •Clorgilin •Esupron •Harmala alkaloidi (Harmin,Harmalin,Tetrahidroharmin,Harman,Norarman, etc) •Metilensko plavo •Metralindol •Minaprin •Moklobemid •Pirlindol •Serkloremin •Tetrindol •Toloksaton •Tirima;MAO-B selektivni:D-Deprenil •Selegilin (L-Deprenil) •Ladostigil •Lazabemid •Milacemid •Mofegilin •Pargilin •Rasagilin
* MAO-B inhibitori takođe utiču na norepinefrin/epinefrin pošto oni inhibiraju razlaganje njihovog prekursora dopamina.

COMT

Entakapon •Tolkapon

Drugi

Prekursori	L-Fenilalanin →L-Tirozin →L-DOPA (Levodopa) →Dopamin •L-DOPS (Droksidopa)
Kofaktori	Ferozni Gvožđe (Fe²⁺) •S-Adenozil-L-Metionin •Vitamin B₃ (Niacin,Nikotinamid →NADPH) •Vitamin B₆ (Piridoksin,Piridoksamin,Piridoksal →Piridoksal Fosfat) •Vitamin B₉ (Folna kiselina →Tetrahidrofolna kiselina) •Vitamin C (Askorbinska kiselina) •Cink (Zn²⁺)
Drugi	Pojačivaći aktivnosti:BPAP •PPAP;Blokatori oslobađanja:Betanidin •Bretilijum •Gvanadrel •Gvanazodin •Gvanklofin •Gvanetidin •Gvanoksan;Toksini:Oksidopamin (6-Hidroksidopamin)

Izvor:https://sh.wikipedia.org/w/index.php?title=Alfa-2B_adrenergički_receptor&oldid=42509397

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