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AM-411

Izvor: Wikipedija
AM-411
(IUPAC) ime
(6aR,10aR)-3-(1-adamantil)-6,6,9-trimetil-6a,7,10,10a-tetrahidrobenzo[c]hromen-1-ol
Klinički podaci
Identifikatori
ATC kod?
PubChem[1][2]9799945
ChemSpider[3]7975710
ChEMBL[4]CHEMBL434351 DaY
Hemijski podaci
FormulaC26H34O2 
Mol. masa378.546 g/mol
SMILESeMolekuli &PubHem
InChI
InChI=1S/C26H34O2/c1-15-4-5-21-20(6-15)24-22(27)10-19(11-23(24)28-25(21,2)3)26-12-16-7-17(13-26)9-18(8-16)14-26/h4,10-11,16-18,20-21,27H,5-9,12-14H2,1-3H3/t16?,17?,18?,20-,21-,26?/m1/s1 DaY
Key: RPBMPWGKZFLMFN-OKFSJJLXSA-N DaY
Farmakoinformacioni podaci
Trudnoća?
Pravni status

AM-411 jeanalgetički lek koji jekanabinoidniagonist. AM-411 je potentan i u znatnoj meri selektivan CB1 pun agonist saKi od 6,80 nM, ali je isto tako umereno potentan CB2 agonist sa Ki od 52,0nM.[5]

Reference

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  1. ↑Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. ↑Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. ↑Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. ↑Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  5. ↑Lu D,et al. Adamantyl cannabinoids: a novel class of cannabinergic ligands.Journal of Medicinal Chemistry. 2005 Jul 14;48(14):4576-85.PMID 15999995

Povezano

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Šablon:Kanabinoidi

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