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ACTH receptor

Uredi veze

Izvor: Wikipedija

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Melanokortin 2 receptor (adrenokortikotropski hormon)

Identifikatori

Simboli

MC2R; ACTHR; MGC125798

Vanjski ID

OMIM: 607397MGI: 96928HomoloGene: 444IUPHAR:MC₂GeneCards:MC2R Gene

Ontologija gena
Molekularna funkcija	•rodopsinu-slična receptorska aktivnost•receptorska aktivnost•adrenokortikotropska receptorska aktivnost
Celularna komponenta	•integralno sa membranom plazme•membrana
Biološki proces	•prenos signala•G-protein signalizacija, spregnuta sa cikličnim nukleotidnim drugim glasnikom

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

RefSeq (mRNA)

RefSeq (protein)

Lokacija (UCSC)

Chr 18:
13.87 - 13.91 Mb

Chr 18:
68.53 - 68.55 Mb

PubMed pretraga

[1]

[2]

ACTH receptor je tipmelanokortin receptora (tip 2), takođe poznat kaoMC₂, koji je specifičan zaACTH.^[1]

On je rasprostranjen uzona fasciculata ljudskogadrenalnog korteksa. ACTH vezivanje za receptor stimuliše produkcijukortizola. (U kontrastu s tim, produkcijaaldosterona izzona glomerulosa je stimulisana primarnoangiotenzinom II.)

ACTH receptor koristicAMP kao sekundarni glasnik.^[2]

Mutacije ovog receptora uzrokujuglukokortikoidnu deficijenciju tipa 1, u kojoj pacijenti imaju visoke ACTH nivoe u serumu, i niske nivoekortizola.^[3]^[4]

Povezano

[uredi |uredi kod]

Melanokortin receptor

Reference

[uredi |uredi kod]

↑Beuschlein F, Fassnacht M, Klink A, Allolio B, Reincke M (2001). „ACTH-receptor expression, regulation and role in adrenocortial tumor formation”. Eur. J. Endocrinol. 144 (3): 199–206. DOI:10.1530/eje.0.1440199. PMID 11248736.
↑Elias LLK, Clark AJL (2000). „The expression of the ACTH receptor”. Brazilian Journal of Medical and Biological Research 33 (10): 1245–1248. DOI:10.1590/S0100-879X2000001000015. PMID 11004726.
↑Clark AJL, McLoughlin L, Grossman A (October 1993). „Familial glucocorticoid deficiency associated with point mutation in the adrenocorticotropin receptor”. Lancet 341 (8843): 461–462. DOI:10.1016/0140-6736(93)90208-X. PMID 8094489.
↑Tsigos C, Arai K, Hung W, Chrousos GP (November 1993). „Hereditary isolated glucocorticoid deficiency is associated with abnormalities of the adrenocorticotropin receptor gene”. J. Clin. Invest. 92 (5): 2458–2461. DOI:10.1172/JCI116853. PMC 288430. PMID 8227361.

Literatura

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Cone RD, Mountjoy KG, Robbins LS,et al. (1993). „Cloning and functional characterization of a family of receptors for the melanotropic peptides.”. Ann. N. Y. Acad. Sci. 680: 342–63. DOI:10.1111/j.1749-6632.1993.tb19694.x. PMID 8390157.
Allolio B, Reincke M (1997). „Adrenocorticotropin receptor and adrenal disorders.”. Horm. Res. 47 (4-6): 273–8. DOI:10.1159/000185476. PMID 9167964.
Tatro JB (1997). „Receptor biology of the melanocortins, a family of neuroimmunomodulatory peptides.”. Neuroimmunomodulation 3 (5): 259–84. DOI:10.1159/000097281. PMID 9218248.
Mountjoy KG, Robbins LS, Mortrud MT, Cone RD (1992). „The cloning of a family of genes that encode the melanocortin receptors.”. Science 257 (5074): 1248–51. DOI:10.1126/science.1325670. PMID 1325670.
Clark AJ, McLoughlin L, Grossman A (1993). „Familial glucocorticoid deficiency associated with point mutation in the adrenocorticotropin receptor.”. Lancet 341 (8843): 461–2. DOI:10.1016/0140-6736(93)90208-X. PMID 8094489.
Tsigos C, Arai K, Hung W, Chrousos GP (1993). „Hereditary isolated glucocorticoid deficiency is associated with abnormalities of the adrenocorticotropin receptor gene.”. J. Clin. Invest. 92 (5): 2458–61. DOI:10.1172/JCI116853. PMC 288430. PMID 8227361.
Gantz I, Tashiro T, Barcroft C,et al. (1994). „Localization of the genes encoding the melanocortin-2 (adrenocorticotropic hormone) and melanocortin-3 receptors to chromosomes 18p11.2 and 20q13.2-q13.3 by fluorescence in situ hybridization.”. Genomics 18 (1): 166–7. DOI:10.1006/geno.1993.1448. PMID 8276410.
Gantz I, Konda Y, Tashiro T,et al. (1993). „Molecular cloning of a novel melanocortin receptor.”. J. Biol. Chem. 268 (11): 8246–50. PMID 8463333.
Naville D, Barjhoux L, Jaillard C,et al. (1996). „Demonstration by transfection studies that mutations in the adrenocorticotropin receptor gene are one cause of the hereditary syndrome of glucocorticoid deficiency.”. J. Clin. Endocrinol. Metab. 81 (4): 1442–8. DOI:10.1210/jc.81.4.1442. PMID 8636348.
Naville D, Jaillard C, Barjhoux L,et al. (1997). „Genomic structure and promoter characterization of the human ACTH receptor gene.”. Biochem. Biophys. Res. Commun. 230 (1): 7–12. DOI:10.1006/bbrc.1996.5911. PMID 9020063.
Yang YK, Ollmann MM, Wilson BD,et al. (1997). „Effects of recombinant agouti-signaling protein on melanocortin action.”. Mol. Endocrinol. 11 (3): 274–80. DOI:10.1210/me.11.3.274. PMID 9058374.
Naville D, Barjhoux L, Jaillard C,et al. (1997). „Stable expression of normal and mutant human ACTH receptor: study of ACTH binding and coupling to adenylate cyclase.”. Mol. Cell. Endocrinol. 129 (1): 83–90. DOI:10.1016/S0303-7207(97)04043-4. PMID 9175632.
Penhoat A, Naville D, Jaillard C,et al. (1997). „Presence of multiple functional polyadenylation signals in the 3'-untranslated region of human corticotropin receptor cDNA.”. Biochim. Biophys. Acta 1356 (3): 249–52. DOI:10.1016/S0167-4889(97)00031-1. PMID 9194567.
Ishii T, Ogata T, Sasaki G,et al. (2000). „Novel mutations of the ACTH receptor gene in a female adult patient with adrenal unresponsiveness to ACTH.”. Clin. Endocrinol. (Oxf) 53 (3): 389–92. DOI:10.1046/j.1365-2265.2000.01040.x. PMID 10971458.
Flück CE, Martens JW, Conte FA, Miller WL (2002). „Clinical, genetic, and functional characterization of adrenocorticotropin receptor mutations using a novel receptor assay.”. J. Clin. Endocrinol. Metab. 87 (9): 4318–23. DOI:10.1210/jc.2002-020501. PMID 12213892.
Swords FM, Baig A, Malchoff DM,et al. (2003). „Impaired desensitization of a mutant adrenocorticotropin receptor associated with apparent constitutive activity.”. Mol. Endocrinol. 16 (12): 2746–53. DOI:10.1210/me.2002-0099. PMID 12456795.
Strausberg RL, Feingold EA, Grouse LH,et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
„Melanocortin Receptors: MC₂”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano izoriginala na datum 2016-03-03.

Vanjske veze

[uredi |uredi kod]

MeSHMC2+Receptor

Transmembranski receptor:G protein spregnuti receptori

Klasa A:Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A,B,D) • α2 (A,B,C) • β1 • β2 • β3
Purinski	Adenozinski (A1,A2A,A2B,A3) • P2Y (1,2,4,5,6,8,9,10,11,12,13,14)
Serotoninski	(svi osim 5-HT3)5-HT1 (A,B,D,E,F) • 5-HT2 (A,B,C) • 5-HT (4,5A,6,7)
Drugi	Acetilholin (M1,M2,M3,M4,M5) • Dopamin (D1,D2,D3,D4,D5) • Histamin (H1,H2,H3,H4) • Melatonin (1A,1B,1C) • TAAR (1,2,3,5,6,8,9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1,2) • LTB4 (1,2) • FPRL1 • OXE • Prostaglandin (DP (1,2),EP (1,2,3,4),FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1,CB2,GPR (18,55,119)) • EBI2 • Estrogen • Slobodna masna kiselina (1,2,3,4) • Laktat • Lizofosfatidna kiselina (1,2,3,4,5,6) • Lizofosfolipid (1,2,3,4,5,6,7,8) • Niacin (1,2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1,2,3,4,5) • Sukcinat

Peptid

Neuropeptidni

B/W (1,2) • FF (1,2) • S • Y (1,2,4,5) • Neuromedin (B,U (1,2)) • Neurotenzin (1,2)

Drugi

Anafilatoksin (C3a,C5a) • Angiotenzin (1,2) • Apelin • Bombezin (BRS3,GRPR,NMBR) • Bradikinin (B1,B2) • Hemokin • Holecistokinin (A,B) • Endotelin (A,B) • Formil peptid (1,2,3) • FSH • Galanin (1,2,3) • GHB receptor • Gonadotropin-oslobađajući hormon (1,2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1,1L,D,E,F,G,X1,X2,X3,X4) • Melanokortin (1,2,3,4,5) • MCHR (1,2) • Motilin • Opioidni (δ,κ,μ,Nociceptin &ζ, ali neσ) • Oreksin (1,2) • Oksitocin • Prokineticin (1,2) • Prolaktin-oslobađajući peptid • Relaksin (1,2,3,4) • Somatostatin (1,2,3,4,5) • Tahikinin (1,2,3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A,1B,2)

Razno

Orfan	GPR (1,3,4,6,12,15,17,18,19,20,21,22,23,25,26,27,31,32,33,34,35,37,39,42,44,45,50,52,55,61,62,63,65,68,75,77,78,81,82,83,84,85,87,88,92,101,103,109A,109B,119,120,132,135,137B,139,141,142,146,148,149,150,151,152,153,160,161,162,171,173,174,176,177,182,183)
Drugi	Adrenomedulin • Mirisni • Opsin (3,4,5,1LW,1MW,1SW,RGR,RRH) • Proteazom-aktivirani (1,2,3,4) • SREB (1,2,3)

Klasa B:Sekretinu slični

Orfan

GPR (56,64,97,98,110,111,112,113,114,115,116,123,124,125,126,128,133,143,144,155,157)

Drugi

Moždano specifični angiogenezni inhibitor (1,2,3) • Cadherin (1,2,3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1,2) • EMR (1,2,3) • Glukagon (GR,GIPR,GLP1R,GLP2R) • Hormon rasta oslobađajući hormon • PACAPR1 • GPR • Latrofilin (1,2,3,ELTD1) • Metuselah-slični proteini • Paratiroidni hormon (1,2) • Sekretin • Vazoaktivni intestinalni peptid (1,2)

Klasa C:Metabotropni
glutamat /feromon

Ukus	TAS1R (1,2,3) • TAS2R (1,3,4,5,8,9,10,12,13,14,16,19,20,30,31,38,39,40,41,42,43,45,46,50)
Drugi	Kalcijum-detektujući receptor • GABA B (1,2) • Glutamatni receptor (Metabotropni glutamat (1,2,3,4,5,6,7,8)) • GPRC6A • GPR (156,158,179) • RAIG (1,2,3,4)

Klasa F:
Frizzled /Zaglađeni

Uvojiti	Frizzled (1,2,3,4,5,6,7,8,9,10)
Zaglađeni	Zaglađeni

B trdu:peptidi (nrpl/grfl/cytl/horl),receptori (lgic,enzr,gprc,igsr,intg,nrpr/grfr/cytr),itra (adap,gbpr,mapk),calc,lipd, signalni putevi (hedp,wntp,tgfp+mapp,notp,jakp,fsap,hipp,tlrp)

Neuropeptidni ligandi

Holecistokinin

CCK_A	Agonisti:Holecistokinin •CCK-4 Antagonisti:Asperlicin •Proglumid •Lorglumid •Devazepid •Deksloksiglumid
CCK_B	Agonisti:Holecistokinin •CCK-4 •Gastrin Antagonisti:Proglumid •CI-988

CRH

CRF₁	Agonisti:Kortikotropin-oslobađajući hormon Antagonisti:Antalarmin •CP-154,526 •Peksacerfont
CRF₂	Agonisti:Kortikotropin-oslobađajući hormon

Galanin

GAL₁	Agonisti:Galanin •Galaninu-sličan peptid •Galmic •Galnon
GAL₂	Agonisti:Galanin •Galaninu-sličan peptid •Galmic •Galnon
GAL₃	Agonisti:Galanin •Galmic •Galnon

Grelin

Agonisti:Grelin •Kapromorelin •MK-677 •Sermorelin •SM-130,686 •Tabimorelin

MCH

MCH₁	Agonisti:Melanin-koncentrirajući hormon Antagonisti:ATC-0175 •GW-803,430 •NGD-4715 •SNAP-7941 •SNAP-94847
MCH₂	Agonisti:Melanin-koncentrirajući hormon

Melanokortin

MC₁	Agonisti:alfa-MSH •Afamelanotid •Bremelanotid •Melanotan II Antagonisti:Aguti signalni peptid
MC₂	Agonisti:ACTH •Kosintropin •Tetrakosaktid
MC₃	Agonisti:alfa-MSH •Bremelanotid •Melanotan II
MC₄	Agonisti:alfa-MSH •Bremelanotid •Melanotan II •THIQ Antagonisti:Agutiju srodni peptid
MC₅	Agonisti:alfa-MSH •Melanotan II

Neuropeptid S

Agonisti:Neuropeptid S
Antagonisti:SHA-68

Neuropeptid Y

Y₁	Agonisti:Neuropeptid Y •Peptid YY Antagonisti:BIBP-3226
Y₂	Agonisti:Neuropeptid Y •Peptid YY Antagonisti:BIIE-0246
Y₄	Agonisti:Neuropeptid Y •Pankreasni polipeptid •Peptid YY Antagonisti:UR-AK49
Y₅	Agonisti:Neuropeptid Y •Peptid YY Antagonisti:Lu AA-33810

Neurotenzin

NTS₁	Agonisti:Neurotenzin •Neuromedin N Antagonisti:SR-48692 •SR-142,948
NTS₂	Agonisti:Neurotenzin Antagonisti:Levokabastin •SR-142,948

Opioid

vidiOpioidi

Oreksin

OX₁	Agonisti:Oreksin-A Antagonisti:Almoreksant •SB-334,867 •SB-408,124 •SB-649,868
OX₂	Agonisti:Oreksin-A Antagonisti:Almoreksant •SB-649,868 •TCS-OX2-29

Oksitocin

Agonisti:Karbetocin •Demoksitocin •Oksitocin •WAY-267,464
Antagonisti:Atosiban •L-371,257 •L-368,899

Tahikinin

NK₁	Agonisti:Supstanca P Antagonisti:Aprepitant •Befetupitant •Kasopitant •CI-1021 •CP-96,345 •CP-99,994 •CP-122,721 •Dapitant •Ezlopitant •FK-888 •Fosaprepitant •GR-203,040 •GW-597,599 •HSP-117 •L-733,060 •L-741,671 •L-743,310 •L-758,298 •Lanepitant •LY-306,740 •Maropitant •Netupitant •NKP-608 •Nolpitantium •Orvepitant •RP-67,580 •SDZ NKT 343 •Vestipitant •Vofopitant
NK₂	Agonisti:Neurokinin A Antagonisti:GR-159897 •Ibodutant •Saredutant
NK₃	Agonisti:Neurokinin B Antagonisti:Osanetant •Talnetant

Vazopresin

V_1A	Agonisti:Dezmopresin •Felipresin •Ornipresin •Terlipresin •Vazopresin Antagonisti:Konivaptan •Demeklociklin •Relkovaptan
V_1B	Agonisti:Felipresin •Ornipresin •Terlipresin •Vazopresin Antagonisti:Demeklociklin •Nelivaptan
V₂	Agonisti:Dezmopresin •Ornipresin •Vazopresin Antagonisti:Konivaptan •Demeklociklin •Liksivaptan •Mozavaptan •Satavaptan •Tolvaptan

Izvor:https://sh.wikipedia.org/w/index.php?title=ACTH_receptor&oldid=42505987

Kategorija:

Ljudski proteini

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