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5-HT_1E receptor

Uredi veze

Izvor: Wikipedija

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5-HT_1E serotoninski receptor

Identifikatori

Simboli

HTR1E; 5-HT1E

Vanjski ID

OMIM: 182132HomoloGene: 55491IUPHAR:5-ht_1eGeneCards:HTR1E Gene

Ontologija gena
Molekularna funkcija	•aktivnost rodopsinu-sličnog receptora•receptorska aktivnost•aktivnost serotoninskog receptora
Celularna komponenta	•integralno sa ćelijskom membranom•membrana
Biološki proces	•prenos signala•G-proteinska signalizacija, spregnuta sa cikličnim nukleotidnim sekundarnim glasnikom•sinaptička transmisija

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

n/a

n/a

n/a

RefSeq (mRNA)

NM_000865

n/a

RefSeq (protein)

NP_000856

n/a

Lokacija (UCSC)

Chr 6:
87.7 - 87.78 Mb

n/a

PubMed pretraga

[1]

n/a

5-HT1E receptor, (5-hidroksitriptaminski (serotoninski) 1E receptor, 5-HT_1E) je visoko izraženi humaniG-protein spregnuti receptor^[1] koji pripada familiji5-HT1 receptora (G_i-spregnutih serotoninskih receptora).^[2]^[3] Humanigen se označava saHTR1E.^[4]

Funkcija

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Funkcija 5-HT_1E receptora nije poznata usled nedostatka selektivnih farmakoloških oruđa, specifičnihantitela, i podobnih životinjskih modela.^[5] Gen 5-HT_1E receptora nema polimorfizama među ljudima (mali je broj mutacija), što je indikacija visokog nivoa evolucionekonzervacije njegove genetičke sekvence, iz čega sledi da 5-HT_1E receptor ima važnu fiziološku ulogu kod ljudi.^[6] Pretpostavlja se da 5-HT_1E receptor učestvuje u regulacijimemorije kod ljudi, zbog zbog visoke zastupljenosti ovog receptora u frontalnom korteksu, hipokampusu, i bulbus olfactorius, što su integralni moždani regioni za regulaciju memorije.^[7]

Ovaj receptor je jedinstven među serotoninskim receptorima po tome što nije izražen kodglodarskih vrsta. Tim vrstama nedostaje gen koji kodira 5-HT_1E receptor. Međutimgenomi svinje, rezus majmuna, i nekoliko lagomorfa (što obuhvatamorsko prase izeca) sadrže homologne 5-HT_1E gene.^[7] Morsko prase je najverovatniji kandidat za buduća ispitivanja funkcije 5-HT_1E receptorin vivo. Izražavanje 5-HT_1E receptora u mozgu morskog praseta je farmakološki potvrđeno. Obrasci izražavanja 5-HT_1E receptora u mozgu ljudi i morskog praseta su slični.^[5]

Selektivni ligandi

[uredi |uredi kod]

Visoko selektivni ligandi 5-HT_1E još uvek nisu dostupni. [³H]5-HT je jedini dostupni radioligand visokogafinita za 5-HT_1E receptor (5 nM).

Agonisti

[uredi |uredi kod]

BRL-54443 (5-Hidroksi-3-(1-metilpiperidin-4-il)-1H-indol) - mešoviti 5-HT_1E/1F agonist

Antagonisti

[uredi |uredi kod]

Antagonisti nisu poznati.

Povezano

[uredi |uredi kod]

Reference

[uredi |uredi kod]

↑Leonhardt S., Herrick-Davis K. and Titeler M. (1989) Detection of a novel serotonin receptor subtype (5-HT1E) in human brain: interaction with a GTP-binding protein. Journal of neurochemistry 53, 465-471. (1989). „Detection of a novel serotonin receptor subtype (5-HT1E) in human brain: interaction with a GTP-binding protein.”. Journal of neurochemistry 53 (2): 465–71. DOI:10.1111/j.1471-4159.1989.tb07357.x. PMID 2664084.
↑McAllister G., Charlesworth A., Snodin C., Beer M. S., Noble A. J., Middlemiss D. N., Iversen L. L. and Whiting P. (1992) Molecular cloning of a serotonin receptor from human brain (5HT1E): a fifth 5HT1-like subtype. Proceedings of the National Academy of Sciences of the United States of America 89, 5517-5521. (1992). „Molecular cloning of a serotonin receptor from human brain (5HT1E): a fifth 5HT1-like subtype.”. Proceedings of the National Academy of Sciences of the United States of America 89 (12): 5517–21. DOI:10.1073/pnas.89.12.5517. PMC 49323. PMID 1608964.
↑Levy F. O., Gudermann T., Birnbaumer M., Kaumann A. J. and Birnbaumer L. (1992) Molecular cloning of a human gene (S31) encoding a novel serotonin receptor mediating inhibition of adenylyl cyclase. FEBS Lett 296, 201-206. (1994). „Assignment of the gene encoding the 5-HT1E serotonin receptor (S31) (locus HTR1E) to human chromosome 6q14-q15.”. Genomics 22 (3): 637–40. DOI:10.1006/geno.1994.1439. PMID 8001977.
↑„Entrez Gene: HTR1E 5-hydroxytryptamine (serotonin) receptor 1E”.
↑^5,0^5,1Klein, M. T., and M. Teitler. "Guinea Pig Hippocampal 5-Htie Receptors: A Tool for Selective Drug Development." J Neurochem 109, no. 1 (2009): 268-74. (2009). „Guinea pig hippocampal 5-HT(1E) receptors: a tool for selective drug development.”. Journal of neurochemistry 109 (1): 268–74. DOI:10.1111/j.1471-4159.2009.05958.x. PMC 2827198. PMID 19200348.
↑Shimron-Abarbanell D., Nothen M. M., Erdmann J. and Propping P. (1995) Lack of genetically determined structural variants of the human serotonin-1E (5-HT1E) receptor protein points to its evolutionary conservation. Brain Res Mol Brain Res 29, 387-390. (1995). „Lack of genetically determined structural variants of the human serotonin-1E (5-HT1E) receptor protein points to its evolutionary conservation.”. Brain research. Molecular brain research 29 (2): 387–90. DOI:10.1016/0169-328X(95)00003-B. PMID 7609628.
↑^7,0^7,1Bai F., Yin T., Johnstone E. M., Su C., Varga G., Little S. P. and Nelson D. L. (2004) Molecular cloning and pharmacological characterization of the guinea pig 5-HT1E receptor. European journal of pharmacology 484, 127-139. (2004). „Molecular cloning and pharmacological characterization of the guinea pig 5-HT1E receptor.”. European journal of pharmacology 484 (2-3): 127–39. DOI:10.1016/j.ejphar.2003.11.019. PMID 14744596.

Literatura

[uredi |uredi kod]

Zgombick JM, Schechter LE, Macchi M,et al. (1992). „Human gene S31 encodes the pharmacologically defined serotonin 5-hydroxytryptamine1E receptor.”. Mol. Pharmacol. 42 (2): 180–5. PMID 1513320.
McAllister G, Charlesworth A, Snodin C,et al. (1992). „Molecular cloning of a serotonin receptor from human brain (5HT1E): a fifth 5HT1-like subtype.”. Proc. Natl. Acad. Sci. U.S.A. 89 (12): 5517–21. DOI:10.1073/pnas.89.12.5517. PMC 49323. PMID 1608964.
Levy FO, Gudermann T, Birnbaumer M,et al. (1992). „Molecular cloning of a human gene (S31) encoding a novel serotonin receptor mediating inhibition of adenylyl cyclase.”. FEBS Lett. 296 (2): 201–6. DOI:10.1016/0014-5793(92)80379-U. PMID 1733778.
Levy FO, Holtgreve-Grez H, Taskén K,et al. (1995). „Assignment of the gene encoding the 5-HT1E serotonin receptor (S31) (locus HTR1E) to human chromosome 6q14-q15.”. Genomics 22 (3): 637–40. DOI:10.1006/geno.1994.1439. PMID 8001977.
Pierce PA, Xie GX, Meuser T, Peroutka SJ (1997). „5-Hydroxytryptamine receptor subtype messenger RNAs in human dorsal root ganglia: a polymerase chain reaction study.”. Neuroscience 81 (3): 813–9. DOI:10.1016/S0306-4522(97)00235-2. PMID 9316030.

Vanjske veze

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„5-HT_1e”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano izoriginala na datum 2016-03-04.

Transmembranski receptor:G protein spregnuti receptori

Klasa A:Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A,B,D) • α2 (A,B,C) • β1 • β2 • β3
Purinski	Adenozinski (A1,A2A,A2B,A3) • P2Y (1,2,4,5,6,8,9,10,11,12,13,14)
Serotoninski	(svi osim 5-HT3)5-HT1 (A,B,D,E,F) • 5-HT2 (A,B,C) • 5-HT (4,5A,6,7)
Drugi	Acetilholin (M1,M2,M3,M4,M5) • Dopamin (D1,D2,D3,D4,D5) • Histamin (H1,H2,H3,H4) • Melatonin (1A,1B,1C) • TAAR (1,2,3,5,6,8,9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1,2) • LTB4 (1,2) • FPRL1 • OXE • Prostaglandin (DP (1,2),EP (1,2,3,4),FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1,CB2,GPR (18,55,119)) • EBI2 • Estrogen • Slobodna masna kiselina (1,2,3,4) • Laktat • Lizofosfatidna kiselina (1,2,3,4,5,6) • Lizofosfolipid (1,2,3,4,5,6,7,8) • Niacin (1,2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1,2,3,4,5) • Sukcinat

Peptid

Neuropeptidni

B/W (1,2) • FF (1,2) • S • Y (1,2,4,5) • Neuromedin (B,U (1,2)) • Neurotenzin (1,2)

Drugi

Anafilatoksin (C3a,C5a) • Angiotenzin (1,2) • Apelin • Bombezin (BRS3,GRPR,NMBR) • Bradikinin (B1,B2) • Hemokin • Holecistokinin (A,B) • Endotelin (A,B) • Formil peptid (1,2,3) • FSH • Galanin (1,2,3) • GHB receptor • Gonadotropin-oslobađajući hormon (1,2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1,1L,D,E,F,G,X1,X2,X3,X4) • Melanokortin (1,2,3,4,5) • MCHR (1,2) • Motilin • Opioidni (δ,κ,μ,Nociceptin &ζ, ali neσ) • Oreksin (1,2) • Oksitocin • Prokineticin (1,2) • Prolaktin-oslobađajući peptid • Relaksin (1,2,3,4) • Somatostatin (1,2,3,4,5) • Tahikinin (1,2,3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A,1B,2)

Razno

Orfan	GPR (1,3,4,6,12,15,17,18,19,20,21,22,23,25,26,27,31,32,33,34,35,37,39,42,44,45,50,52,55,61,62,63,65,68,75,77,78,81,82,83,84,85,87,88,92,101,103,109A,109B,119,120,132,135,137B,139,141,142,146,148,149,150,151,152,153,160,161,162,171,173,174,176,177,182,183)
Drugi	Adrenomedulin • Mirisni • Opsin (3,4,5,1LW,1MW,1SW,RGR,RRH) • Proteazom-aktivirani (1,2,3,4) • SREB (1,2,3)

Klasa B:Sekretinu slični

Orfan

GPR (56,64,97,98,110,111,112,113,114,115,116,123,124,125,126,128,133,143,144,155,157)

Drugi

Moždano specifični angiogenezni inhibitor (1,2,3) • Cadherin (1,2,3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1,2) • EMR (1,2,3) • Glukagon (GR,GIPR,GLP1R,GLP2R) • Hormon rasta oslobađajući hormon • PACAPR1 • GPR • Latrofilin (1,2,3,ELTD1) • Metuselah-slični proteini • Paratiroidni hormon (1,2) • Sekretin • Vazoaktivni intestinalni peptid (1,2)

Klasa C:Metabotropni
glutamat /feromon

Ukus	TAS1R (1,2,3) • TAS2R (1,3,4,5,8,9,10,12,13,14,16,19,20,30,31,38,39,40,41,42,43,45,46,50)
Drugi	Kalcijum-detektujući receptor • GABA B (1,2) • Glutamatni receptor (Metabotropni glutamat (1,2,3,4,5,6,7,8)) • GPRC6A • GPR (156,158,179) • RAIG (1,2,3,4)

Klasa F:
Frizzled /Zaglađeni

Uvojiti	Frizzled (1,2,3,4,5,6,7,8,9,10)
Zaglađeni	Zaglađeni

B trdu:peptidi (nrpl/grfl/cytl/horl),receptori (lgic,enzr,gprc,igsr,intg,nrpr/grfr/cytr),itra (adap,gbpr,mapk),calc,lipd, signalni putevi (hedp,wntp,tgfp+mapp,notp,jakp,fsap,hipp,tlrp)

Serotonergici

Ligandi 5-HT₁ receptora

5-HT_1A	Agonisti:Azapironi:Alnespiron •Binospiron •Buspiron •Enilospiron •Eptapiron •Gepiron •Ipsapiron •Perospiron •Revospiron •Tandospiron •Tiospiron •Umespiron •Zalospiron;Antidepresivi:Etoperidon •Nefazodon •Trazodon;Antipsihotici:Aripiprazol •Asenapin •Klozapin •Kvetiapin •Ziprasidon;Ergolini:Dihidroergotamin •Ergotamin •Lisurid •Metisergid •LSD;Triptamini:5-CT •5-MeO-DMT •5-MT •Bufotenin •DMT •Indorenat •Psilocin •Psilocibin;Drugi:8-OH-DPAT •Adatanserin •Bay R 1531 •Befiradol •BMY-14802 •Kanabidiol •Dimemebfe •Ebalzotan •Eltoprazin •F-11,461 •F-12,826 •F-13,714 •F-14,679 •F-15,063 •F-15,599 •Flesinoksan •Flibanserin •Lesopitron •Lu AA21004 •LY-293,284 •LY-301,317 •MKC-242 •NBUMP •Osemozotan •Oksaflozan •Pardoprunoks •Piklozotan •Rauvolscin •Repinotan •Roksindol •RU-24,969 •S 14,506 •S-14,671 •S-15,535 •Sarizotan •SSR-181,507 •Sunepitron •U-92,016-A •Urapidil •Vilazodon •Ksaliproden •Johimbin Antagonisti:Antipsihotici:Iloperidon •Risperidon •Sertindol;Beta blokatori:Alprenolol •Cianopindolol •Jodocianopindolol •Oksprenolol •Pindobind •Pindolol •Propranolol •Tertatolol;Drugi:AV965 •BMY-7,378 •CSP-2503 •Dotarizin •Flopropion •GR-46611 •Isamoltan •Lekozotan •Metitepin/Metiotepin •MPPF •NAN-190 •PRX-00023 •Robalzotan •S-15535 •SB-649,915 •SDZ 216-525 •Spiperon •Spiramid •Spiroksatrin •UH-301 •WAY-100,135 •WAY-100,635 •Ksilamidin
5-HT_1B	Agonisti:Lisergamidi:Dihidroergotamin •Ergotamin •Metisergid;Piperazini:Eltoprazin •TFMPP;Triptani:Avitriptan •Eletriptan •Sumatriptan •Zolmitriptan;Triptamini:5-CT •5-MT;Drugi:CGS-12066A •CP-93,129 •CP-94,253 •CP-135,807 •RU-24,969 Antagonisti:Lisergamidi:Metergolin;Drugi:AR-A000002 •Elzasonan •GR-127,935 •Isamoltan •Metitepin/Metiotepin •SB-216,641 •SB-224,289 •SB-236,057 •Johimbin
5-HT_1D	Agonisti:Lisergamidi:Dihidroergotamin •Metisergid;Triptani:Almotriptan •Avitriptan •Eletriptan •Frovatriptan •Naratriptan •Rizatriptan •Sumatriptan •Zolmitriptan;Triptamini:5-CT •5-Etil-DMT •5-MT •5-(Noniloksi)triptamin;Drugi:CP-135,807 •CP-286,601 •GR-46611 •L-694,247 •L-772,405 •PNU-109,291 •PNU-142,633 Antagonisti:Lisergamidi:Metergolin;Drugi:Alniditan •BRL-15,572 •Elzasonan •GR-127,935 •Ketanserin •LY-310,762 •LY-367,642 •LY-456,219 •LY-456,220 •Metitepin/Metiotepin •Ritanserin •Johimbin •Ziprasidon
5-HT_1E	Agonisti:Lisergamidi:Metisergid;Triptani:Eletriptan;Triptamini:BRL-54443 •Triptamin Antagonisti:Metitepin/Metiotepin
5-HT_1F	Agonisti:Triptani:Eletriptan •Naratriptan •Sumatriptan;Triptamini:5-MT;Drugi:BRL-54443 •Lasmiditan •LY-334,370 Antagonisti:Metitepin/Metiotepin

Ligandi5-HT₂ receptora

5-HT_2A	Agonisti:Lisergamidi:ALD-52 •Ergometrin •Lisurid •LA-SS-Az •LSD •LSD-Pip •2-butil amid liserginske kiseline •3-pentil amid liserginske kiseline •Metisergid;Fenetilamini:25I-NBF •25I-NBMD •25I-NBOH •25I-NBOMe •2C-B •2C-B-FLY •2CB-Ind •2C-C-NBOMe •2C-E •2C-I •2C-TFM-NBOMe •2C-T-2 •2C-T-7 •2C-T-21 •2CBCB-NBOMe •2CBFly-NBOMe •Bromo-DragonFLY •DOB •DOC •DOI •DOM •MDA •MDMA •Meskalin •TCB-2 •TFMFly;Piperazini:BZP •Hipazin •TFMPP;Triptamini:5-CT •5-MeO-α-ET •5-MeO-α-MT •5-MeO-DET •5-MeO-DiPT •5-MeO-DMT •5-MeO-DPT •5-MT •α-ET •α-Metil-5-HT •α-MT •Bufotenin •DET •DiPT •DMT •DPT •Psilocin •Psilocibin;Drugi:AL-34662 •AL-37350A •Dimemebfe •Medifoksamin •Oksaflozan •PNU-22394 •RH-34 Antagonisti:Atipični antipsihotici:Amperozid •Aripiprazol •Karpipramin •Klokapramin •Klozapin •Gevotrolin •Iloperidon •Melperon •Mosapramin •Olanzapin •Paliperidon •Pimozid •Hetiapin •Risperidon •Sertindol •Ziprasidon •Zotepin;Tipični antipsihotici:Loksapin •Pipamperon;Antidepresivi:Amitriptilin •Amoksapin •Aptazapin •Etoperidon •Mianserin •Mirtazapin •Nefazodon •Trazodon;Drugi:5-I-R91150 •AC-90179 •Adatanserin •Altanserin •AMDA •APD-215 •Blonanserin •Cinanserin •CSP-2503 •Ciproheptadin •Deramciklan •Dotarizin •Eplivanserin •Esmirtazapin •Fananserin •Flibanserin •Ketanserin •KML-010 •Lubazodon •Mepiprazol •Metitepin/Metiotepin •Nantenin •Pimavanserin •Pizotifen •Pruvanserin •Rauvolscin •Ritanserin •S-14,671 •Sarpogrelat •Setoperon •Spiperon •Spiramid •SR-46349B •Volinanserin •Ksilamidin •Johimbin
5-HT_2B	Agonisti:Oksazolini:4-Metilaminoreks •Aminoreks;Fenetilamini:Hlorfentermin •Kloforeks •DOB •DOC •DOI •DOM •Fenfluramin •MDA •MDMA •Norfenfluramin;Triptamini:5-CT •5-MT •α-Metil-5-HT;Drugi:BW-723C86 •Kabergolin •mCPP •Pergolid •PNU-22394 •Ro60-0175 Antagonisti:Agomelatin •Asenapin •EGIS-7625 •Ketanserin •Lisurid •LY-272,015 •Metitepin/Metiotepin •PRX-08066 •Rauvolscin •Ritanserin •RS-127,445 •Sarpogrelat •SB-200,646 •SB-204,741 •SB-206,553 •SB-215,505 •SB-221,284 •SB-228,357 •SDZ SER-082 •Tegaserod •Johimbin
5-HT_2C	Agonisti:Fenetilamini:2C-B •2C-E •2C-I •2C-T-2 •2C-T-7 •2C-T-21 •DOB •DOC •DOI •DOM •MDA •MDMA •Meskalin;Piperazini:Aripiprazol •mCPP •TFMPP;Triptamini:5-CT •5-MeO-α-ET •5-MeO-α-MT •5-MeO-DET •5-MeO-DiPT •5-MeO-DMT •5-MeO-DPT •5-MT •α-ET •α-Metil-5-HT •α-MT •Bufotenin •DET •DiPT •DMT •DPT •Psilocin •Psilocibin;Drugi:A-372,159 •AL-38022A •CP-809,101 •Dimemebfe •Lorkaserin•Medifoksamin •MK-212 •Org 12,962 •ORG-37,684 •Oksaflozan •PNU-22394 •Ro60-0175 •Ro60-0213 •Vabicaserin •WAY-629 •WAY-161,503 •YM-348 Antagonisti:Atipični antipsihotici:Klozapin •Iloperidon •Melperon •Olanzapin •Paliperidon •Pimozid •Hetiapin •Risperidon •Sertindol •Ziprasidon •Zotepin;Tipični antipsihotici:Hlorpromazin •Loksapin •Pipamperon;Antidepresivi:Agomelatin •Amitriptilin •Amoksapin •Aptazapin •Etoperidon •Fluoksetin •Mianserin •Mirtazapin •Nefazodon •Nortriptilin •Trazodon;Drugi:Adatanserin •Cinanserin •Ciproheptadin •Deramciklan •Dotarizin •Eltoprazin •Esmirtazapin •FR-260,010 •Ketanserin •Ketotifen •Latrepirdin •Lu AA24530 •Metitepin/Metiotepin •Metisergid •Pizotifen •Ritanserin •RS-102,221 •S-14,671 •SB-200,646 •SB-206,553 •SB-221,284 •SB-228,357 •SB-242,084 •SB-243,213 •SDZ SER-082 •Ksilamidin

Ligandi5-HT₃,5-HT₄,5-HT₅,5-HT₆, i5-HT₇ receptora

5-HT₃	Agonisti:Piperazini:BZP •Hipazin;Triptamini:2-Metil-5-HT •5-CT;Drugi:Hlorofenilbiguanid •Butanol •Etanol •Halotan •Izofluran •RS-56812 •SR-57,227 •SR-57,227-A •Toluen •Trihloroetan •Trihloroetanol •Trihloroetilen •YM-31636 Antagonisti:Antiemetici:AS-8112 •Alosetron •Azasetron •Batanoprid •Bemesetron •Cilansetron •Dazoprid •Dolasetron •Granisetron •Lerisetron •Ondansetron •Palonosetron •Ramosetron •Renzaprid •Tropisetron •Zacoprid •Zatosetron;Atipični antipsihotici:Klozapin •Olanzapin •Hetiapin;Tetraciklični antidepresivi:Amoksapin •Mianserin •Mirtazapin;Drugi:CSP-2503 •ICS-205,930 •Lu AA21004 •Lu AA24530 •MDL-72,222 •Memantin •Azot-monoksid •Ricasetron •Sevofluran •Tujon •Ksenon
5-HT₄	Agonisti:Gastroprokinetički agensi:Cinitaprid •Cisaprid •Dazoprid •Metoklopramid •Mosaprid •Prukaloprid •Renzaprid •Tegaserod •Zakoprid;Drugi:5-MT •BIMU8 •CJ-033,466 •PRX-03140 •RS-67333 •RS-67506 •SL65.0155 •TD-5108 Antagonisti:GR-113,808 •GR-125,487 •L-Lizin •Piboserod •RS-39604 •RS-67532 •SB-203,186
5-HT_5A	Agonisti:Lisergamidi:Ergotamin •LSD;Triptamini:5-CT;Drugi:Valerenska kiselina Antagonisti:Asenapin •Latrepirdin •Metitepin/Metiotepin •Ritanserin •SB-699,551 *5-HT_5B receptor nije funkcionalan kod ljudi.
5-HT₆	Agonisti:Lisergamidi:Dihidroergotamin •Ergotamin •Lisurid •LSD •Mesulergin •Metergolin •Metisergid;Triptamini:2-Metil-5-HT •5-BT •5-CT •5-MT •Bufotenin •E-6801 •E-6837 •EMD-386,088 •EMDT •LY-586,713 •N-Metil-5-HT •Triptamin;Drugi:WAY-181,187 •WAY-208,466 Antagonisti:Antidepresanti:Amitriptilin •Amoksapin •Klomipramin •Doksepin •Mianserin •Nortriptilin;Atipični antipsihotici:Aripiprazol •Asenapin •Klozapin •Fluperlapin •Iloperidon •Olanzapin •Tiospiron;Tipični antipsihotici:Hlorpromazin •Loksapin;Drugi:BGC20-760 •BVT-5182 •BVT-74316 •EGIS-12,233 •GW-742,457 •Ketanserin •Latrepirdin •Lu AE58054 •Metitepin/Metiotepin •MS-245 •PRX-07034 •Ritanserin •Ro04-6790 •Ro 63-0563 •SB-258,585 •SB-271,046 •SB-357,134 •SB-399,885 •SB-742,457
5-HT₇	Agonisti:Lisergamidi:LSD;Triptamini:5-CT •5-MT •Bufotenin;Drugi:8-OH-DPAT •AS-19 •Bifeprunoks •LP-12 •LP-44 •RU-24,969 •Sarizotan Antagonisti:Lisergamidi:2-Bromo-LSD •Bromokriptin •Dihidroergotamin •Ergotamin •Mesulergin •Metergolin •Metisergid;Antidepresanti:Amitriptilin •Amoksapin •Klomipramin •Imipramin •Maprotilin •Mianserin;Atipični antipsihotici:Amisulprid •Aripiprazol •Klozapin •Olanzapin •Risperidon •Sertindol •Tiospiron •Ziprasidon •Zotepin;Tipični antipsihotici:Hlorpromazin •Loksapin;Drugi:Butaklamol •EGIS-12,233 •Ketanserin •LY-215,840 •Metitepin/Metiotepin •Pimozid •Ritanserin •SB-258,719 •SB-258,741 •SB-269,970 •SB-656,104 •SB-656,104-A •SB-691,673 •SLV-313 •SLV-314 •Spiperon •SSR-181,507

Inhibitori preuzimanja

SERT

Selektivni inhibitori preuzimanja serotonina (SSRI):Alaproklat •Citalopram •Dapoksetin •Desmetilcitalopram •Desmetilsertralin •Escitalopram •Femoksetin •Fluoksetin •Fluvoksamin •Indalpin •Ifoksetin •Litoksetin •Lu AA21004 •Lubazodon •Panuramin •Paroksetin •Pirandamin •RTI-353 •Seproksetin •Sertralin •Vilazodon •Zimelidin;Inhibitori preuzimanja serotonin-norepinefrina (SNRI):Bicifadin •Desvenlafaksin •Duloksetin •Eklanamin •Levomilnacipran •Milnacipran •Sibutramin •Venlafaksin;Inhibitori preuzimanja serotonin-norepinefrin-dopamina (SNDRI):Brasofensin •Diklofensin •DOV-102,677 •DOV-21,947 •DOV-216,303 •NS-2359 •SEP-225289 •SEP-227,162 •Tesofensin;Triciklični antidepresivi (TCAs):Amitriptilin •Butriptilin •Cianopramin •Klomipramin •Desipramin •Dosulepin •Doksepin •Imipramin •Lofepramin •Nortriptilin •Pipofezin •Protriptilin •Trimipramin;Tetraciklični antidepresanti (TeCA):Amoksapin;Piperazini:Nefazodon •Trazodon;Antihistamini:Bromfeniramin •Hlorfenamin •Difenhidramin •Mepiramin/Pirilamin •Feniramin •Tripelenamin;Opioidi:Petidin •Metadon •Propoksifen;Drugi:Kokain •CP-39,332 •Ciklobenzaprin •Dekstrometorfan •Dekstrorfan •EXP-561 •Fezolamin •Mesembrin •Nefopam •PIM-35 •Pridefin •Roksindol •SB-649,915 •Ziprasidon

VMAT

Ibogain •Reserpin •Tetrabenazin

Agensi otpuštanja

Aminoindani:5-IAI •AMMI •ETAI •MDAI •MDMAI •MMAI •TAI;Aminotetralini:6-CAT •8-OH-DPAT •MDAT •MDMAT;Oksazolini:4-Metilaminoreks •Aminoreks •Klominoreks •Fluminoreks;Fenetilamini (takođeAmfetamini,Katinoni,Fentermini, itd):2-Metil-MDA •4-CAB •4-FA •4-FMA •4-HA •4-MTA •5-APDB •5-Metil-MDA •6-APDB •6-Metil-MDA •AEMMA •Amiflamin •BDB •BOH •Brefedron •Butilon •Hlorfentermin •Kloforeks •Amfepramon •Metamfepramon •DFMDA •DMA •DMMA •EBDB •EDMA •Etilon •Etoloreks •Fenfluramin (Deksfenfluramin) •Flefedron •IAP •IMP •Lofofin •MBDB •MDA •MDEA •MDHMA •MDMA •MDMPEA •MDOH •MDPEA •Mefedron •Metedron •Metilon •MMA •MMDA •MMDMA •MMMA •NAP •Norfenfluramin •4-TFMA •pBA •pCA •pIA •PMA •PMEA •PMMA •TAP;Piperazini:2C-B-BZP •2-BZP •3-MeOPP •BZP •DCPP •MBZP •mCPP •MDBZP •MeOPP •Mepiprazol •pCPP •pFPP •pTFMPP •TFMPP;Triptamini:4-Metil-αET •4-Metil-αMT •5-CT •5-MeO-αET •5-MeO-αMT •5-MT •αET •αMT •DMT •Triptamin (sam);Drugi:Indeloksazin •Tramadol •Viqualin

Inhibitori enzima

Anabolizam

TPH	AGN-2979 •Fenklonin
AAAD	Benserazid •Karbidopa •Genistein •Metildopa

Katabolizam

MAO

Neselektivni:Benmoksin •Karoksazon •Ehinopsidin •Furazolidon •Hidralazin •Indantadol •Iproklozid •Iproniazid •Izokarboksazid •Izoniazid •Linezolid •Mebanazin •Metfendrazin •Nialamid •Oktamoksin •Paraksazon •Fenelzin •Feniprazin •Fenoksipropazin •Pivalilbenzhidrazin •Prokarbazin •Safrazin •Tranilcipromin;MAO-A selektivni:Amiflamin •Bazinaprin •Befloksaton •Befol •Brofaromin •Cimoksaton •Klorgilin •Esupron •Harmala alkaloidi (Harmin,Harmalin,Tetrahidroharmin,Harman,Norharman, itd) •Metilensko plavo •Metralindol •Minaprin •Moklobemid •Pirlindol •Serkloremin •Tetrindol •Toloksaton •Tirima

Drugi

Prekursori	L-Triptofan →5-HTP
Kofaktori	Fero gvožđe (Fe²⁺) •Magnezijum (Mg²⁺) •Tetrahidrobiopterin •Vitamin B₃ (Niacin,Nikotinamid →NADPH) •Vitamin B₆ (Piridoksin,Piridoksamin,Piridoksal →Piridoksal fosfat) •Vitamin B₉ (Folna kiselina →Tetrahidrofolna kiselina) •Vitamin C (Askorbinska kiselina) •Cink (Zn²⁺)
Drugi	Pojačivači aktivnosti:BPAP •PPAP;Pojačivači preuzimanja:Tianeptin

Izvor:https://sh.wikipedia.org/w/index.php?title=5-HT1E_receptor&oldid=42507383

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