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Cover; Title Page; Front Matter; Copyright; ABOUT THE AUTHORS; AUSTRALIAN AND NEW ZEALAND CONTRIBUTORS; US CONTRIBUTORS; REVIEWERS; PREFACE; Table of Contents; PART ONE: Essential concepts of pathophysiology; Introduction to essential concepts of pathophysiology; Chapter 1: INTRODUCTION TO CLINICAL SCIENCE; Chapter 2: HOMEOSTASIS; Chapter 3: CELLULAR STRUCTURE AND FUNCTION; Chapter 4: ALTERED CELLULAR FUNCTION; Chapter 5: GENES; PART TWO: Alterations to regulation and control; Introduction to alterations to regulation and control. Chapter 6: THE STRUCTURE AND FUNCTION OF THE NEUROLOGICAL SYSTEMChapter 7: PAIN; Chapter 8: CONCEPTS OF NEUROLOGICAL DYSFUNCTION; Chapter 9: ALTERATIONS OF NEUROLOGICAL FUNCTION ACROSS THE LIFE SPAN; Chapter 10: THE STRUCTURE AND FUNCTION OF THE ENDOCRINE SYSTEM; Chapter 11: ALTERATIONS OF ENDOCRINE FUNCTION ACROSS THE LIFE SPAN; PART THREE: Alterations to protection and movement; Introduction to alterations to protection and movement; Chapter 12: THE STRUCTURE AND FUNCTION OF THE IMMUNE SYSTEM; Chapter 13: INFLAMMATION AND FEVER; Chapter 14: INFECTION. Chapter 15: ALTERATIONS OF IMMUNE FUNCTION ACROSS THE LIFE SPANChapter 16: THE STRUCTURE AND FUNCTION OF THE HAEMATOLOGICAL SYSTEM; Chapter 17: ALTERATIONS OF HAEMATOLOGICAL FUNCTION ACROSS THE LIFE SPAN; Chapter 18: THE STRUCTURE AND FUNCTION OF THE INTEGUMENTARY SYSTEM; Chapter 19: ALTERATIONS OF THE INTEGUMENTARY SYSTEM ACROSS THE LIFE SPAN; Chapter 20: THE STRUCTURE AND FUNCTION OF THE MUSCULOSKELETAL SYSTEM; Chapter 21: ALTERATIONS OF MUSCULOSKELETAL FUNCTION ACROSS THE LIFE SPAN; PART FOUR: Alterations to body maintenance; Introduction to Alterations to body maintenance. Chapter 22: THE STRUCTURE AND FUNCTION OF THE CARDIOVASCULAR AND LYMPHATIC SYSTEMSChapter 23: ALTERATIONS OF CARDIOVASCULAR FUNCTION ACROSS THE LIFE SPAN; Chapter 24: THE STRUCTURE AND FUNCTION OF THE PULMONARY SYSTEM; Chapter 25: ALTERATIONS OF PULMONARY FUNCTION ACROSS THE LIFE SPAN; Chapter 26: THE STRUCTURE AND FUNCTION OF THE DIGESTIVE SYSTEM; Chapter 27: ALTERATIONS OF DIGESTIVE FUNCTION ACROSS THE LIFE SPAN; Chapter 28: THE STRUCTURE AND FUNCTION OF THE URINARY SYSTEM; Chapter 29: FLUIDS AND ELECTROLYTES, ACIDS AND BASES. Chapter 30: ALTERATIONS OF RENAL FUNCTION AND FLUID BALANCE ACROSS THE LIFE SPANPART FIVE: Alterations to continuity; Introduction to Alterations to continuity; Chapter 31: THE STRUCTURE AND FUNCTION OF THE REPRODUCTIVE SYSTEMS; Chapter 32: ALTERATIONS OF THE REPRODUCTIVE SYSTEMS ACROSS THE LIFE SPAN; PART SIX: Contemporary health issues; Introduction to contemporary health issues; Chapter 33: INTRODUCTION TO CONTEMPORARY HEALTH ISSUES; Chapter 34: STRESS; Chapter 35: OBESITY AND DIABETES MELLITUS; Chapter 36: CANCER; Chapter 37: GENES, GENETIC DISEASES AND THE ENVIRONMENT