Environmental neurotoxicology
Presenting the consensus on risk assessment and environmental toxicants, this book covers: the biologic basis of neurotoxicity; progress in the application of biologic markers; reviews of a range of in vitro and in vivo testing techniques; and more. It is useful for policymakers, health specialists, researchers, and students.
1 online resource (xii, 154 pages) : illustrations
9780585143798, 9780309597609, 9781280203657, 058514379X, 0309597609, 128020365X
44957274
CURRENT IN VIVO PROCEDURES
Behavioral Assessment
Functional Observational Batteries
Motor Activity
Schedule-Controlled Operant Behavior
Specialized Tests of Neurologic Function
Motor Function
Sensory Function
Learning and Memory
Neurophysiologic Procedures
Nerve-Conduction Studies
Sensory Evoked Potentials
Electroencephalography
Neurochemical Procedures
Neuroendocrine Interactions
Neuropathology
Imaging Procedures
Modifying Variables
Age at Exposure
Age at Testing
Sex
Genetic Differences
CURRENT REGULATORY APPROACHES
STRATEGIES FOR IMPROVED NEUROTOXICITY TESTING
Screening
Validation
Priority-Setting and Implementation
Research Needs
5 Surveillance to Prevent Neurotoxicity in Humans
Need for Surveillance
NEUROBEHAVIOURAL TEST BATTERIES
CURRENT EXPOSURE SURVEILLANCE EFFORTS
CURRENT DISEASE-SURVEILLANCE EFFORTS
6 Risk Assessment
APPROACHES TO RISK ASSESSMENT FOR NEUROTOXICITY
CURVE-FITTING IN RISK ASSESSMENT FOR NEUROTOXICITY
MECHANISTIC MODELS FOR RISK ASSESSMENT FOR NEUROTOXICITY
SUMMARY
7 Conclusions and Recommendations
References
Index
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