Physical biology : from atoms to medicine
This is an avant-garde book edited by Nobel Laureate Ahmed Zewail with contributions from eminent scientists including four Nobel prize winners. The perspectives of these world leaders in physics, chemistry, and biology define potential new frontiers at the interface of disciplines and including physical, systems, and synthetic biology. This book brings about the confluence of concepts and tools, and that of different disciplines, to address significant problems of our time: visualization; theory and computation for complexity; macromolecular function, protein folding and misfolding; and systems integration from cells to consciousness. The scope of tools is wide-ranging, spanning imaging, crystallography, microfluidics, single-molecule spectroscopy, and synthetic probe targeting. Concepts such as dynamic self-assembly, molecular recognition, non-canonical amino acids, and others are covered in various chapters as they are cornerstones in building the trilogy description of behavior-structure, dynamics, and function. The volume is uniquely structured to provide overviews with historical perspectives on the evolution of ideas and on the future of physical biology and biological complexity, from atoms to medicine
1 online resource (xiii, 567 pages) : illustrations (some color)
9781848162013, 9781908978875, 9781281866196, 9786611866198, 1848162014, 1908978872, 1281866199, 6611866191
294759396
Print version:
Ch. 1. The preoccupations of twenty-first-century biology / David Baltimore
ch. 2. The world as physics, mathematics and nothing else / Alexander Varshavsky
ch. 3. Physical biology: 4D visualization of complexity / Ahmed H. Zewail
ch. 4. Revolutionary developments from atomic to extended structural imaging / John Meurig Thomas
ch. 5. Physical biology at the crossroads / Carlos J. Bustamante
ch. 6. The challenge of quasi-regular structures in biology / Roger D. Kornberg
ch. 7. The future of biological X-ray analysis / Douglas C. Rees
ch. 8. Reinterpreting the genetic code: implications for macromolecular design, evolution and analysis / David A. Tirrell
ch. 9. Designing ligands to bind tightly to proteins / George M. Whitesides [and others]
ch. 10. Biology by the numbers / Rob Phillips
ch. 11. Eppur si muove / Michele Parrinello
ch. 12. Protein folding and beyond: energy landscapes and the organization of living matter in time and space / Peter G. Wolynes
ch. 13. Protein folding and misfolding: from atoms to organisms / Christopher M. Dobson
ch. 14. A systems approach to medicine will transform healthcare / Leroy Hood
ch. 15. The neurobiology of consciousness / Christof Koch and Florian Mormann
ch. 16. Computer-aided drug discovery: physics-based simulations from the molecular to the cellular level / J. Andrew McCammon
ch. 17. Precision measurements in biology / Stephen R. Quake
ch. 18. Potassium channels and the atomic basis of selective ion conduction / Roderick MacKinnon
The 2007 Welch award papers. ch. 19. Symmetry breaking, delocalization and dynamics in electron transfer systems / Noel S. Hush. ch. 20. The initial value representation of semiclassical theory: a practical way for adding quantum effects to classical molecular dynamics simulations of complex molecular systems / William H. Miller
Biographies
English
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