The "Scots" that wis uised in this airticle wis written bi a body that haesna a guid grip on the leid. Pleasemak this airticle mair better gin ye can. (Dizember 2020)
Salicylic acid, the main metabolite o aspirin, is an integral pairt o human an ainimal metabolism. While in humans much o it is attributable tae diet, a substantial pairt is synthesizedendogenously.[3]
Aspirin forby haes anantiplatelet effect bi inhibitin the production othromboxane, which unner normal circumstances bindsplatelet molecules thegither tae create a patch ower damaged walls o bluid vessels. Acause the platelet patch can acome too muckle an block bluid flow an aw, locally an dounstream, aspirin is uised lang-term, at law doses, tae help preventhert attacks,strokes, anbluid clot formation in fowk at heich risk o developin bluid clots an aw.[4] It haes been established that law doses o aspirin mey be gien immediately efter a hert attack tae reduce the risk o anither hert attack or o the daith o cardiac tissue an aw.[5][6]Aspirin mey be effective at preventin certain types o cancer, parteecularlycolorectal cancer.[7][7][8][9]
Aspirin is pairt o a group o medications criednonsteroidal anti-inflammatory drugs (NSAIDs), but differs frae maist ither NSAIDs in themechanism o action. Tho it, an ithers in its group cried the salicylates, hae seemilar effects (antipyretic, anti-inflammatory, analgesic) tae the ither NSAIDs an inhibit the same enzymecyclooxygenase, aspirin (but nae the ither salicylates) daes sae in anirreversible manner an, unlik ithers, affects mair the COX-1 variant than the COX-2 variant o the enzyme.[11]
The day, aspirin is ane o the maist widely uised medications in the warld, wi an estimatit 40,000tonnes o it bein consumed each year.[12] In kintras whaur Aspirin is a registered trademark awned biBayer, the generic term is acetylsalicylic acid (ASA).[13]
↑Paterson, JR; Baxter, G; Dreyer, JS; Halket, JM; Flynn, R; Lawrence, JR (24 December 2008). "Salicylic acid sans aspirin in animals and man: persistence in fasting and biosynthesis from benzoic acid".Journal of agricultural and food chemistry.56 (24): 11648–52.PMID19053387.
↑Rothwell, Peter M; Price, Jacqueline F; Fowkes, F Gerald R; Zanchetti, Alberto; Roncaglioni, Maria Carla; Tognoni, Gianni; Lee, Robert; Belch, Jill FF; Wilson, Michelle (2012). "Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: Analysis of the time course of risks and benefits in 51 randomised controlled trials".The Lancet.379 (9826): 1602.doi:10.1016/S0140-6736(11)61720-0.
↑Rothwell, Peter M; Wilson, Michelle; Price, Jacqueline F; Belch, Jill FF; Meade, Tom W; Mehta, Ziyah (2012). "Effect of daily aspirin on risk of cancer metastasis: A study of incident cancers during randomised controlled trials".The Lancet.379 (9826): 1591.doi:10.1016/S0140-6736(12)60209-8.
