An Additional, Complementary Mechanism of Action for Folic Acid in the Treatment of Megaloblastic Anemia
Abstract:Administration of supplemental folic acid addresses the impaired DNA synthesis causing megaloblastic anemia; however, despite the possibility of high doses of folic acid-5 to 15 milligrams (mg) daily for up to four months-the extremely rapid initial onset of action-30 to 60 minutes-when administered orally is not in keeping with the accepted mechanism, which can take up to nearly 22 hours, even under enzymatic control. This would suggest an additional, complementary non-enzymatic mechanism of nucleotide methyl… Show more
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