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Field-effect sensors – from pH sensing to biosensing: sensitivity enhancement using streptavidin–biotin as a model system
Abstract:a Field-Effect Transistor sensors (FET-sensors) have been receiving increasing attention for biomolecular sensing over the last two decades due to their potential for ultra-high sensitivity sensing, label-free operation, cost reduction and miniaturisation. Whilst the commercial application of FET-sensors in pH sensing has been realised, their commercial application in biomolecular sensing (termed BioFETs) is hindered by poor understanding of how to optimise device design for highly reproducible operation and h… Show more
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Cited by 145 publications
(127 citation statements)
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“…These time-transient behaviors can be understood by the Langmuir model, which has been commonly used to analyze the kinetics of surface binding reactions for systems having the ligand immobilized on a solid surface.[27,28,29,30,31,32] In the model, the response signal of the sensor for the time-dependent molecular reaction is expressed in the form of a characteristic exponential function, [33] namely association curve, which is displayed as solid lines in Fig. 3a.…”
Section: Analysis Of Kinetics Of Streptavidin and Biotin Complexmentioning
confidence: 99%
On-chip label-free biosensing based on active whispering gallery mode resonators pumped by a light-emitting diode
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD).Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD.The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC).Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…These time-transient behaviors can be understood by the Langmuir model, which has been commonly used to analyze the kinetics of surface binding reactions for systems having the ligand immobilized on a solid surface.[27,28,29,30,31,32] In the model, the response signal of the sensor for the time-dependent molecular reaction is expressed in the form of a characteristic exponential function, [33] namely association curve, which is displayed as solid lines in Fig. 3a.…”
Section: Analysis Of Kinetics Of Streptavidin and Biotin Complexmentioning
confidence: 99%
On-chip label-free biosensing based on active whispering gallery mode resonators pumped by a light-emitting diode
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD).Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD.The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC).Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Recently, sensing technologies have emerged that apply electric fields to direct flow, separate biomolecules, or modulate surface potentials. However, few researchers have investigated the behavior of confined molecules in flows driven by electric fields.…”
Section: Introductionmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD).Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD.The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC).Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…This field effect has been harvested to design the first generation of nanowire, carbon nanotube, and graphene‐based field‐effect transistor (GFET). The experimental preparations and observations of the electric field effect in nanomaterials have inspired numerous experimental and theoretical works related to the application of nanoscale field‐effect transistors (FETs) for high performance label‐free biochemical sensors…”
Section: Introductionmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD).Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD.The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC).Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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