2015Help me understand this report
|
Sign up to set email alerts
Sensory gating disturbances in the spectrum: Similarities and differences in schizotypal personality disorder and schizophrenia
Abstract:BackgroundDSM-5 places schizophrenia on a continuum from severe, chronic schizophrenia to the attenuated schizophrenia-like traits of schizotypal personality disorder (SPD), the prototypic schizophrenia-related personality disorder. SPD shares common genetic and neurobiological substrates with schizophrenia, including information processing abnormalities, although they are less marked. This is the first study to directly compare the P50 evoked electroencephalographic response—a measure of sensory gating and a… Show more
Search citation statements
Order By: Relevance
Paper Sections
Select...
34
6
5
0
Citation Types
5
19
0
2
Year Published
2016
20162024
2024Publication Types
Select...
31
4
4
3
Relationship
0
42
Authors
Journals
Cited by 42 publications
(26 citation statements)
References 87 publications
5
19
0
2
Order By: Relevance
“…Our current findings extend those of our own group and other researchers who established continuity across clinical populations with schizophrenia and related disorders in terms of, for example, sensory gating26 and white matter integrity.27 The variety of techniques used to place disorders like schizotypal PD on a gradient with schizophrenia indicates that the “spectrum” nature of psychosis applies across modalities.…”
Section: Discussionsupporting
confidence: 88%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD).Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD.The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC).Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Our current findings extend those of our own group and other researchers who established continuity across clinical populations with schizophrenia and related disorders in terms of, for example, sensory gating26 and white matter integrity.27 The variety of techniques used to place disorders like schizotypal PD on a gradient with schizophrenia indicates that the “spectrum” nature of psychosis applies across modalities.…”
Section: Discussionsupporting
confidence: 88%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD).Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD.The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC).Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…This finding is in line with conclusions drawn from studies reporting reduced P50 sensory gating in patients with schizotypal personality disorder, i.e. that an abnormal P50 ratio is a neurocognitive deficit across the psychosis spectrum(Cadenhead et al, 2000(Cadenhead et al, , 2002Hazlett et al, 2015).…”
Section: P50supporting
confidence: 91%
“…The authors therefore do not rule out a contribution of P50 amplitude elicited by S1 to sensory gating deficiencies. This 'gating-in' deficit has been described in patients with schizophrenia(Greenwood et al, 2016;Johannesen et al, 2005;Smith et al, 2013;Zhu et al, 2017;Zouridakis et al, 1997) and schizotypal personality disorder(Hazlett et al, 2015). Correspondingly, we found that P50 sensory gating deficiency in patients with BPD and AVH seems to be caused by a diminished response to the S1 stimulus rather than to the S2 stimulus.…”
Section: Discussionsupporting
confidence: 79%
Sensory processing deficiencies in patients with borderline personality disorder who experience auditory verbal hallucinations
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD).Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD.The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC).Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…reported in both the schizophrenia and bipolar disorder patients(53)(54)(55), the sensory gating deficit has been suggested to partly underlie the cognitive and perceptual symptoms in the disorders(3,56). Therefore, our dynamic FC findings may further support the hypothesis that thalamo-sensorimotor connectivity disturbances and sensory gating deficits are common neurobiological features shared by schizophrenia and bipolar disorder(4,53).…”
Section: Discussionsupporting
confidence: 77%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD).Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD.The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC).Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
Scite is an AI-powered platform that helps researchers discover and evaluate scientific literature through Smart Citations, showing whether studies support or contradict a claim. Now part of Research Solutions, Scite has indexed 1.4B+ citations, partners with 30+ publishers, and serves 2M users worldwide.
Contact Info
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Resources
This site is protected by reCAPTCHA and the GooglePrivacy Policy andTerms of Service apply.
Copyright © 2026 Scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.
