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The role of iron in brain ageing and neurodegenerative disorders
Abstract:In the CNS, iron in several proteins is involved in many important processes such as oxygen transportation, oxidative phosphorylation, myelin production, and the synthesis and metabolism of neurotransmitters. Abnormal iron homoeostasis can induce cellular damage through hydroxyl radical production, which can cause the oxidation and modification of lipids, proteins, carbohydrates, and DNA. During ageing, different iron complexes accumulate in brain regions associated with motor and cognitive impairment. In vari… Show more
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Cited by 1,719 publications
(1,695 citation statements)
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“…Increased generation of ROS in the hippocampus following iron exposure as observed in the present study could be associated with decreased mitochondrial membrane potential and is consistent with earlier reports[68,76]. ROS production may decrease the effectiveness of the antioxidant system and affects numerous cellular components[13]. In fact, the elevation in ROS production found in our study was accompanied by an increase in MDA, protein carbonyl.…”
Section: Discussionsupporting
confidence: 93%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD).Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD.The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC).Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Increased generation of ROS in the hippocampus following iron exposure as observed in the present study could be associated with decreased mitochondrial membrane potential and is consistent with earlier reports[68,76]. ROS production may decrease the effectiveness of the antioxidant system and affects numerous cellular components[13]. In fact, the elevation in ROS production found in our study was accompanied by an increase in MDA, protein carbonyl.…”
Section: Discussionsupporting
confidence: 93%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD).Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD.The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC).Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…The very high increase in nigral Fe that we measured cannot therefore be attributed to the age difference between the groups of control subjects (65 years on average) and PD patients (78.5 years). Our study thus confirms existing observations showing increased Fe deposition in the SN of PD at the tissue level (Ayton et al.,2013; Dexter et al.,1989; Genoud et al.,2017; Hirsch et al.,1991; Jellinger et al.,1990; Lhermitte et al.,1924; Ward et al.,2014). Our results also confirm that Fe content is higher in NM neurons from PD patients versus controls at the single neuron level (Davies et al.,2014; Friedrich et al.,2021; Oakley et al.,2007).…”
Section: Discussionsupporting
confidence: 92%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD).Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD.The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC).Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…The red nucleus has been previously less investigated and, in some studies, the absolute magnitude of susceptibility increase was higher for the red nucleus than for the putamen(22,27,29), similarly as in our study. Our observation of milder gradual increase of magnetic susceptibility in the caudate nucleus, substantia nigra, and dentate nucleus is also concordant with postmortem evidence(16) and several previous in vivo MRI studies(9,13,14,27,28).…”
Section: Discussionsupporting
confidence: 92%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD).Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD.The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC).Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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