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Transcriptional and Epigenetic Substrates of Methamphetamine Addiction and Withdrawal: Evidence from a Long-Access Self-Administration Model in the Rat
Abstract:Methamphetamine use disorder is a chronic neuropsychiatric disorder characterized by recurrent binge episodes, intervals of abstinence, and relapses to drug use. Humans addicted to methamphetamine experience various degrees of cognitive deficits and other neurological abnormalities that complicate their activities of daily living and their participation in treatment programs. Importantly, models of methamphetamine addiction in rodents have shown that animals will readily learn to give themselves methamphetamin… Show more
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Cited by 73 publications
(69 citation statements)
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“…Given that the brain tissue in our previous study was collected more than 2 weeks following the last METH exposure, it is possible that the observed decrease in MeCP2 expression was due to METH withdrawal rather than METH intake per se. This effect is consistent with previous findings(Liyanage et al, 2015), and METH withdrawal has been shown to alter the expression of several transcription factors(Cadet et al, 2014). In the present study, tissue was collected immediately following SA, and we did not observe a difference in NAc core MeCP2 expression between the ELS-exposed rats and handled controls in the METH condition.…”
Section: Discussionsupporting
confidence: 93%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD).Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD.The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC).Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Given that the brain tissue in our previous study was collected more than 2 weeks following the last METH exposure, it is possible that the observed decrease in MeCP2 expression was due to METH withdrawal rather than METH intake per se. This effect is consistent with previous findings(Liyanage et al, 2015), and METH withdrawal has been shown to alter the expression of several transcription factors(Cadet et al, 2014). In the present study, tissue was collected immediately following SA, and we did not observe a difference in NAc core MeCP2 expression between the ELS-exposed rats and handled controls in the METH condition.…”
Section: Discussionsupporting
confidence: 93%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD).Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD.The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC).Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Our biochemical and molecular measures revealed, in addition, that mu, delta, and kappa receptor protein and mRNA levels were differentially impacted in the striatum and hippocampus of rats that had undergone protracted abstinence following various doses of oxycodone intake, with there being some differences even in rats that were exposed to oxycodone via the long-access paradigm. These differential regional responses are consistent with previous papers documenting brain regional effects of various drugs during different stages of addiction and withdrawal [ 24 , 40 , 45 , 46 ].…”
Section: Discussionsupporting
confidence: 92%
Molecular Adaptations in the Rat Dorsal Striatum and Hippocampus Following Abstinence-Induced Incubation of Drug Seeking After Escalated Oxycodone Self-Administration
Mol Neurobiol
Self Cite
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD).Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD.The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC).Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Higher propensity to relapse shown by SR animals is related to changes in the expression of Creb1 , Cbp , and JunD ( Figure 4 A–F). The changes in Creb1 and Cbp mRNA levels are consistent with our previous data identifying CREB-mediated dependent mechanisms as mediators of METH-induced transcriptional changes in the striatum [ 60 , 63 , 64 , 65 , 66 ].…”
Section: Discussionsupporting
confidence: 91%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD).Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD.The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC).Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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