Smoking cigarettes is associated with increased sperm disomy in teenage men
- PMID:9797104
- DOI: 10.1016/s0015-0282(98)00261-1
Smoking cigarettes is associated with increased sperm disomy in teenage men
Abstract
Objective: To determine whether moderate cigarette smoking and alcohol consumption in teenage men is associated with increases in disomic sperm and detectable changes in semen quality.
Design: Cohort study.
Setting: Military recruiting station, Teplice, Czech Republic.
Patient(s): Ten current smokers (20 cigarettes per day for at least 2 years, exposure confirmed by urine cotinine) who also consumed alcohol and 15 nonsmokers. All patients were exactly 18 years old, healthy, and of unproven fertility.
Main outcome measure(s): Sperm aneuploidy by multicolor fluorescence in situ hybridization for chromosomes 8, X, and Y; conventional semen analyses; computer-aided sperm analysis for motility; and sperm chromatin structure analysis.
Results: Smokers showed elevated frequencies of sperm aneuploidy (Y disomy, P <0.001; aggregate of X, Y, and 8 disomies, P <0.01); reduced linearity of sperm motion (P <0.05); and more "round-headed" sperm (P <0.01). Smokers' semen contained fewer sperm (P <0.001) and fewer motile sperm (P <0.02), which was attributable, in part, to shorter abstinence intervals among smokers (P <0.02).
Conclusion(s): Cigarette smoking among teenagers was associated with increases in disomic sperm and a diminution in specific aspects of semen quality. Such defects may affect male fertility and may increase future chances of fathering offspring with aneuploidy syndromes.
Similar articles
- Cigarette smoking and aneuploidy in human sperm.Shi Q, Ko E, Barclay L, Hoang T, Rademaker A, Martin R.Shi Q, et al.Mol Reprod Dev. 2001 Aug;59(4):417-21. doi: 10.1002/mrd.1048.Mol Reprod Dev. 2001.PMID:11468778
- The relationship between exposure to air pollution and sperm disomy.Jurewicz J, Radwan M, Sobala W, Polańska K, Radwan P, Jakubowski L, Ulańska A, Hanke W.Jurewicz J, et al.Environ Mol Mutagen. 2015 Jan;56(1):50-9. doi: 10.1002/em.21883. Epub 2014 Jul 3.Environ Mol Mutagen. 2015.PMID:24989325
- Individual variation in the frequency of sperm aneuploidy in humans.Rubes J, Vozdova M, Oracova E, Perreault SD.Rubes J, et al.Cytogenet Genome Res. 2005;111(3-4):229-36. doi: 10.1159/000086893.Cytogenet Genome Res. 2005.PMID:16192698
- Cigarette Smoking and Semen Quality: A New Meta-analysis Examining the Effect of the 2010 World Health Organization Laboratory Methods for the Examination of Human Semen.Sharma R, Harlev A, Agarwal A, Esteves SC.Sharma R, et al.Eur Urol. 2016 Oct;70(4):635-645. doi: 10.1016/j.eururo.2016.04.010. Epub 2016 Apr 21.Eur Urol. 2016.PMID:27113031Review.
- Effect of lifestyle exposures on sperm aneuploidy.Robbins WA, Elashoff DA, Xun L, Jia J, Li N, Wu G, Wei F.Robbins WA, et al.Cytogenet Genome Res. 2005;111(3-4):371-7. doi: 10.1159/000086914.Cytogenet Genome Res. 2005.PMID:16192719Review.
Cited by
- Proteome analysis of round-headed and normal spermatozoa by 2-D fluorescence difference gel electrophoresis and mass spectrometry.Liao TT, Xiang Z, Zhu WB, Fan LQ.Liao TT, et al.Asian J Androl. 2009 Nov;11(6):683-93. doi: 10.1038/aja.2009.59. Epub 2009 Oct 12.Asian J Androl. 2009.PMID:19823175Free PMC article.
- Decline of Sperm Quality over the Last Two Decades in the South of Europe: A Retrospective Study in Infertile Patients.Garcia-Grau E, Lleberia J, Costa L, Guitart M, Yeste M, Benet J, Amengual MJ, Ribas-Maynou J.Garcia-Grau E, et al.Biology (Basel). 2022 Dec 30;12(1):70. doi: 10.3390/biology12010070.Biology (Basel). 2022.PMID:36671762Free PMC article.
- Comparison of spermatozoa quality in male smokers and nonsmokers of Iranian infertile couples.Aryanpur M, Tarahomi M, Sharifi H, Heydari G, Hessami Z, Akhoundi M, Masjedi MR.Aryanpur M, et al.Int J Fertil Steril. 2011 Oct;5(3):152-7. Epub 2011 Dec 22.Int J Fertil Steril. 2011.PMID:25101159Free PMC article.
- Parental Substance Abuse As an Early Traumatic Event. Preliminary Findings on Neuropsychological and Personality Functioning in Young Drug Addicts Exposed to Drugs Early.Parolin M, Simonelli A, Mapelli D, Sacco M, Cristofalo P.Parolin M, et al.Front Psychol. 2016 Jun 16;7:887. doi: 10.3389/fpsyg.2016.00887. eCollection 2016.Front Psychol. 2016.PMID:27378983Free PMC article.
- Nuclear and mitochondrial DNA alterations in newborns with prenatal exposure to cigarette smoke.Pirini F, Guida E, Lawson F, Mancinelli A, Guerrero-Preston R.Pirini F, et al.Int J Environ Res Public Health. 2015 Jan 22;12(2):1135-55. doi: 10.3390/ijerph120201135.Int J Environ Res Public Health. 2015.PMID:25648174Free PMC article.Review.
Publication types
MeSH terms
Substances
Related information
LinkOut - more resources
Full Text Sources
Medical