A novel receptor for Apo2L/TRAIL contains a truncated death domain
- PMID:9382840
- DOI: 10.1016/s0960-9822(06)00422-2
A novel receptor for Apo2L/TRAIL contains a truncated death domain
Abstract
Apo2 ligand (Apo2L [1], also called TRAIL for tumor necrosis factor (TNF)-related apoptosis-inducing ligand [2]) belongs to the TNF family and activates apoptosis in tumor cells. Three closely related receptors bind Apo2L: DR4 and DR5, which contain cytoplasmic death domains and signal apoptosis, and DcR1, a decoy receptor that lacks a cytoplasmic tail and inhibits Apo2L function [3-5]. By cross-hybridization with DcR1, we have identified a fourth Apo2L receptor, which contains a cytoplasmic region with a truncated death domain. We subsequently named this protein decoy receptor 2 (DcR2). The DcR2 gene mapped to human chromosome 8p21, as did the genes encoding DR4, DR5 and DcR1. A single DcR2 mRNA transcript showed a unique expression pattern in human tissues and was particularly abundant in fetal liver and adult testis. Upon overexpression, DcR2 did not activate apoptosis or nuclear factor-kappaB; however, it substantially reduced cellular sensitivity to Apo2L-induced apoptosis. These results suggest that DcR2 functions as an inhibitory Apo2L receptor.
Similar articles
- Control of apoptosis signaling by Apo2 ligand.Marsters SA, Pitti RA, Sheridan JP, Ashkenazi A.Marsters SA, et al.Recent Prog Horm Res. 1999;54:225-34.Recent Prog Horm Res. 1999.PMID:10548878Review.
- Receptor-selective mutants of apoptosis-inducing ligand 2/tumor necrosis factor-related apoptosis-inducing ligand reveal a greater contribution of death receptor (DR) 5 than DR4 to apoptosis signaling.Kelley RF, Totpal K, Lindstrom SH, Mathieu M, Billeci K, Deforge L, Pai R, Hymowitz SG, Ashkenazi A.Kelley RF, et al.J Biol Chem. 2005 Jan 21;280(3):2205-12. doi: 10.1074/jbc.M410660200. Epub 2004 Nov 1.J Biol Chem. 2005.PMID:15520016
- Chemotherapeutic agents sensitize osteogenic sarcoma cells, but not normal human bone cells, to Apo2L/TRAIL-induced apoptosis.Evdokiou A, Bouralexis S, Atkins GJ, Chai F, Hay S, Clayer M, Findlay DM.Evdokiou A, et al.Int J Cancer. 2002 Jun 1;99(4):491-504. doi: 10.1002/ijc.10376.Int J Cancer. 2002.PMID:11992538
- TRAIL/Apo2L ligands induce apoptosis in malignant rhabdoid tumor cell lines.Yoshida S, Narita T, Koshida S, Ohta S, Takeuchi Y.Yoshida S, et al.Pediatr Res. 2003 Nov;54(5):709-17. doi: 10.1203/01.PDR.0000085038.53151.D0. Epub 2003 Aug 6.Pediatr Res. 2003.PMID:12904602
- Apo2L/TRAIL and its death and decoy receptors.LeBlanc HN, Ashkenazi A.LeBlanc HN, et al.Cell Death Differ. 2003 Jan;10(1):66-75. doi: 10.1038/sj.cdd.4401187.Cell Death Differ. 2003.PMID:12655296Review.
Cited by
- The role of the immune response and inflammatory pathways in TNF-related apoptosis-inducing ligand (TRAIL) resistance in triple-negative breast cancer cells.Pimentel JM, Zhou JY, Kim S, Gurdziel K, Wu GS.Pimentel JM, et al.Am J Cancer Res. 2023 Oct 15;13(10):4678-4692. eCollection 2023.Am J Cancer Res. 2023.PMID:37970367Free PMC article.
- Is there any correlation between TNF-related apoptosis-inducing ligand (TRAIL) genetic variants and breast cancer?Yildiz Y, Yaylim-Eraltan I, Arikan S, Ergen HA, Küçücük S, Isbir T.Yildiz Y, et al.Arch Med Sci. 2010 Dec;6(6):932-6. doi: 10.5114/aoms.2010.19304. Epub 2010 Dec 29.Arch Med Sci. 2010.PMID:22427769Free PMC article.
- Hypoxia and low glucose differentially augments TRAIL-induced apoptotic death.Lee YJ, Moon MS, Kwon SJ, Rhee JG.Lee YJ, et al.Mol Cell Biochem. 2005 Feb;270(1-2):89-97. doi: 10.1007/s11010-005-5261-8.Mol Cell Biochem. 2005.PMID:15792357
- TNF-related apoptosis-inducing ligand (TRAIL): a new path to anti-cancer therapies.Holoch PA, Griffith TS.Holoch PA, et al.Eur J Pharmacol. 2009 Dec 25;625(1-3):63-72. doi: 10.1016/j.ejphar.2009.06.066. Epub 2009 Oct 18.Eur J Pharmacol. 2009.PMID:19836385Free PMC article.Review.
- Death receptor signaling and autoimmunity.Siegel RM, Muppidi J, Roberts M, Porter M, Wu Z.Siegel RM, et al.Immunol Res. 2003;27(2-3):499-512. doi: 10.1385/IR:27:2-3:499.Immunol Res. 2003.PMID:12857993Review.
MeSH terms
Substances
Associated data
- Actions
Related information
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases