Age-related changes in calbindin D-28k and calretinin immunoreactivity in the inferior colliculus of CBA/CaJ and C57Bl/6 mice
- PMID:9303527
- DOI: 10.1002/(sici)1096-9861(19970915)386:1<92::aid-cne9>3.0.co;2-8
Age-related changes in calbindin D-28k and calretinin immunoreactivity in the inferior colliculus of CBA/CaJ and C57Bl/6 mice
Abstract
This study examines calbindin D-28k and calretinin immunoreactivity in the inferior colliculus (IC) of young and old mice of two strains. The CBA/CaJ mouse maintains good hearing until very late in life, whereas the C57Bl/6 strain exhibits severe sensorineural hearing loss at an early age. Young and old mice of both strains were selected with matching auditory brainstem response audiograms and gap detection thresholds. Brain sections were reacted with anti-calbindin D-28k (CB) and anti-calretinin (CR). Staining patterns were characterized and cell counts performed. CB immunoreactivity was high only in the nucleus of the commissure (NCO); counts revealed a 22.3% decrease in the number of CB+ cells in old CBA mice and a 25.1% decrease in old C57 mice. Calretinin immunoreactivity was high in the pericentral regions of the IC, but the central nucleus was devoid of CR+ cells. The dorsal cortex, lateral nucleus, and NCO showed increases of 42.3, 49.0, and 61%, respectively, in the number of CR+ cells, but only in the old CBA mice. No significant change was observed in the old C57 mice. Whereas decreases in CB immunoreactivity are common with age, this study is the first to report an age-related increase in CR immunoreactivity in the auditory system. The increase in CR+ cells is a possible compensatory adaptation to the decrease in CB+ cells. That the number of CR+ cells remains constant with age in C57 mice suggests this compensation may depend upon stimulus-driven activity, but this requires further study.
Similar articles
- Calbindin D-28k immunoreactivity in the medial nucleus of the trapezoid body declines with age in C57BL/6, but not CBA/CaJ, mice.O'Neill WE, Zettel ML, Whittemore KR, Frisina RD.O'Neill WE, et al.Hear Res. 1997 Oct;112(1-2):158-66. doi: 10.1016/s0378-5955(97)00116-0.Hear Res. 1997.PMID:9367238
- The effects of early bilateral deafening on calretinin expression in the dorsal cochlear nucleus of aged CBA/CaJ mice.Zettel ML, O'Neill WE, Trang TT, Frisina RD.Zettel ML, et al.Hear Res. 2003 Sep;183(1-2):57-66. doi: 10.1016/s0378-5955(03)00216-8.Hear Res. 2003.PMID:13679138
- Early bilateral deafening prevents calretinin up-regulation in the dorsal cortex of the inferior colliculus of aged CBA/CaJ mice.Zettel ML, O'Neill WE, Trang TT, Frisina RD.Zettel ML, et al.Hear Res. 2001 Aug;158(1-2):131-8. doi: 10.1016/s0378-5955(01)00305-7.Hear Res. 2001.PMID:11506945
- Age-related changes in calbindin and calretinin immunoreactivity in the central auditory system of the rat.Ouda L, Burianova J, Syka J.Ouda L, et al.Exp Gerontol. 2012 Jul;47(7):497-506. doi: 10.1016/j.exger.2012.04.003. Epub 2012 Apr 20.Exp Gerontol. 2012.PMID:22548914
- 'New' functions for 'old' proteins: the role of the calcium-binding proteins calbindin D-28k, calretinin and parvalbumin, in cerebellar physiology. Studies with knockout mice.Schwaller B, Meyer M, Schiffmann S.Schwaller B, et al.Cerebellum. 2002 Dec;1(4):241-58. doi: 10.1080/147342202320883551.Cerebellum. 2002.PMID:12879963Review.
Cited by
- Postinhibitory rebound neurons and networks are disrupted in retrovirus-induced spongiform neurodegeneration.Li Y, Davey RA, Sivaramakrishnan S, Lynch WP.Li Y, et al.J Neurophysiol. 2014 Aug 1;112(3):683-704. doi: 10.1152/jn.00227.2014. Epub 2014 May 14.J Neurophysiol. 2014.PMID:25252336Free PMC article.
- Age-related alteration in processing of temporal sound features in the auditory midbrain of the CBA mouse.Walton JP, Frisina RD, O'Neill WE.Walton JP, et al.J Neurosci. 1998 Apr 1;18(7):2764-76. doi: 10.1523/JNEUROSCI.18-07-02764.1998.J Neurosci. 1998.PMID:9502833Free PMC article.
- Subdivisions of the auditory midbrain (n. mesencephalicus lateralis, pars dorsalis) in zebra finches using calcium-binding protein immunocytochemistry.Logerot P, Krützfeldt NO, Wild JM, Kubke MF.Logerot P, et al.PLoS One. 2011;6(6):e20686. doi: 10.1371/journal.pone.0020686. Epub 2011 Jun 20.PLoS One. 2011.PMID:21701681Free PMC article.
- Effects of exposing gonadectomized and intact C57BL/6J mice to a high-frequency augmented acoustic environment: Auditory brainstem response thresholds and cytocochleograms.Willott JF, VandenBosche J, Shimizu T, Ding DL, Salvi R.Willott JF, et al.Hear Res. 2006 Nov;221(1-2):73-81. doi: 10.1016/j.heares.2006.07.016. Epub 2006 Sep 14.Hear Res. 2006.PMID:16973316Free PMC article.
- Clinical neuropathology practice guide 5-2013: markers of neuronal maturation.Sarnat HB.Sarnat HB.Clin Neuropathol. 2013 Sep-Oct;32(5):340-69. doi: 10.5414/NP300638.Clin Neuropathol. 2013.PMID:23883617Free PMC article.Review.
Publication types
MeSH terms
Substances
Related information
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
Molecular Biology Databases
Miscellaneous