Presence of multiple functional polyadenylation signals in the 3'-untranslated region of human corticotropin receptor cDNA
- PMID:9194567
- DOI: 10.1016/s0167-4889(97)00031-1
Presence of multiple functional polyadenylation signals in the 3'-untranslated region of human corticotropin receptor cDNA
Abstract
We present 2.59 kb of the 3'-non-coding region of the ACTH receptor cDNA that contains seven potential polyadenylation signals. Among these signals, five are functional as detected by 3'-RACE and are consistent with the transcripts of 1.8, 3.4 and 4 kb visualized on Northern blots. We propose that the most likely molecular mechanism for the multiple ACTH-R mRNA transcripts is the alternative use of polyadenylation signals.
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