Review
doi: 10.1146/annurev.neuro.20.1.483.PAX-6 in development and evolution
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- PMID:9056723
- DOI: 10.1146/annurev.neuro.20.1.483
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Review
PAX-6 in development and evolution
P Callaerts et al. Annu Rev Neurosci.1997.
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Abstract
Pax-6 is a member of the Pax gene class and encodes a protein containing a paired domain and a homeodomain. The molecular characterization of Pax-6 genes from species of different animal phyla and the analysis of Pax-6 function in the developing eyes and central nervous system of vertebrates, Drosophila melanogaster, and Caenorhabditis elegans suggest that Pax-6 homologues share conserved functions. In this review, we present recent data on the structural and functional characterization of Pax-6 homologues from species of different animal phyla. We discuss the implications of these findings for our understanding of the development and evolution of eyes and nervous systems.
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