doi: 10.1016/s0378-1119(96)00690-7.
CRF2-4: isolation of cDNA clones encoding the human and mouse proteins
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- PMID:9047351
- DOI: 10.1016/s0378-1119(96)00690-7
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CRF2-4: isolation of cDNA clones encoding the human and mouse proteins
V C Gibbs et al. Gene..
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Abstract
To search for genes which encode human interferon receptor molecules, we applied the technique of exon trapping to human chromosome 21 yeast artificial chromosomes (YACs). A full length cDNA encoding human CRF2-4 was identified which is shown here to be widely expressed in human tissues. The human CRF2-4 cDNA was used as a probe to screen a mouse macrophage cDNA library. A mouse CRF2-4 cDNA was isolated which encodes a 349-amino-acid (aa) polypeptide that is 69% identical at the aa level with its human counterpart. Mouse CRF2-4 is predicted to be another member of the interferon receptor-class II cytokine receptor family.
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