doi: 10.1016/0014-2999(96)00254-3.
Interactions of selective serotonin reuptake inhibitors with subtypes of sigma receptors in rat brain
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- PMID:8831113
- DOI: 10.1016/0014-2999(96)00254-3
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Interactions of selective serotonin reuptake inhibitors with subtypes of sigma receptors in rat brain
N Narita et al. Eur J Pharmacol..
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Abstract
The interactions of selective serotonin reuptake inhibitors and tricyclic antidepressants with subtypes of sigma receptors were investigated. The rank order of affinity (Ki values) from competition experiments of [3H](+)-pentazocine binding to sigma 1 sites was: fluvoxamine > sertraline > S(+)-fluoxetine > (+/-)-fluoxetine > citalopram > imipramine > paroxetine > desipramine > R(-)-fluoxetine > (+/-)-norfluoxetine. The Ki values of all drugs for sigma 2 sites were more than 1000 nM. Furthermore, all drugs were more potent at sigma 1 sites than at sigma 2 sites. These findings suggest that sigma receptors (sigma 1 site) may play, in some way, a role in the actions of selective serotonin reuptake inhibitors.
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