doi: 10.1016/0014-5793(96)00186-x.
Tannin interactions with a full-length human salivary proline-rich protein display a stronger affinity than with single proline-rich repeats
Affiliations
- PMID:8605987
- DOI: 10.1016/0014-5793(96)00186-x
Item in Clipboard
Tannin interactions with a full-length human salivary proline-rich protein display a stronger affinity than with single proline-rich repeats
A J Charlton et al. FEBS Lett..
Free article Display options
Format
Display options
Format
Abstract
The protein IB5 has been purified from human parotid saliva. This protein contains several repeats of a short proline-rich sequence. Dissociation constants have been measured at several discrete binding sites using 1H-NMR for the hydrolysable tannins (polyphenols) beta-1,3,6-tri-O-galloyl-D-glucopyranose, beta-1,2,4,6-tetra-O-galloyl-D-glucopyranose and beta-1,2,3,4,6-penta-O-galloyl-D-glucopyranose and the condensed proanthocyanidin (--)-epicatechin. The dissociation constants for trigalloyl glucose and pentagalloyl glucose were 15 X 10(-5) and 1.7 X 10(-5) M, respectively, which are 115 and 1660 times stronger than those previously measured under the same conditions for a single repeat of a mouse salivary proline-rich protein. The increase in affinity is ascribed to intramolecular secondary interactions, which are strengthened by the rigidity of the interacting molecules.
Similar articles
- Study of the interaction between salivary proline-rich proteins and a polyphenol by 1H-NMR spectroscopy.Murray NJ, Williamson MP, Lilley TH, Haslam E.Murray NJ, et al.Eur J Biochem. 1994 Feb 1;219(3):923-35. doi: 10.1111/j.1432-1033.1994.tb18574.x.Eur J Biochem. 1994.PMID:8112344
- Multiple interactions between polyphenols and a salivary proline-rich protein repeat result in complexation and precipitation.Baxter NJ, Lilley TH, Haslam E, Williamson MP.Baxter NJ, et al.Biochemistry. 1997 May 6;36(18):5566-77. doi: 10.1021/bi9700328.Biochemistry. 1997.PMID:9154941
- Interaction of plant polyphenols with salivary proteins.Bennick A.Bennick A.Crit Rev Oral Biol Med. 2002;13(2):184-96. doi: 10.1177/154411130201300208.Crit Rev Oral Biol Med. 2002.PMID:12097360Review.
- Basic proline-rich proteins from human parotid saliva: relationships of the covalent structures of ten proteins from a single individual.Kauffman DL, Bennick A, Blum M, Keller PJ.Kauffman DL, et al.Biochemistry. 1991 Apr 9;30(14):3351-6. doi: 10.1021/bi00228a001.Biochemistry. 1991.PMID:1849422
- Salivary proline-rich proteins: biochemistry, molecular biology, and regulation of expression.Carlson DM.Carlson DM.Crit Rev Oral Biol Med. 1993;4(3-4):495-502. doi: 10.1177/10454411930040033401.Crit Rev Oral Biol Med. 1993.PMID:8374003Review.
Cited by
- Dose-Dependent Effects of L-Arginine on PROP Bitterness Intensity and Latency and Characteristics of the Chemical Interaction between PROP and L-Arginine.Melis M, Arca M, Aragoni MC, Cabras T, Caltagirone C, Castagnola M, Crnjar R, Messana I, Tepper BJ, Tomassini Barbarossa I.Melis M, et al.PLoS One. 2015 Jun 23;10(6):e0131104. doi: 10.1371/journal.pone.0131104. eCollection 2015.PLoS One. 2015.PMID:26103639Free PMC article.
- Free and bound form bioactive compound profiles in germinated black soybean (Glycine max L.).Kim MY, Jang GY, Lee Y, Li M, Ji YM, Yoon N, Lee SH, Kim KM, Lee J, Jeong HS.Kim MY, et al.Food Sci Biotechnol. 2016 Dec 31;25(6):1551-1559. doi: 10.1007/s10068-016-0240-2. eCollection 2016.Food Sci Biotechnol. 2016.PMID:30263444Free PMC article.
- Polyphenol-stabilized tubular elastin scaffolds for tissue engineered vascular grafts.Chuang TH, Stabler C, Simionescu A, Simionescu DT.Chuang TH, et al.Tissue Eng Part A. 2009 Oct;15(10):2837-51. doi: 10.1089/ten.TEA.2008.0394.Tissue Eng Part A. 2009.PMID:19254115Free PMC article.
- Mechanism of gallic acid biosynthesis in bacteria (Escherichia coli) and walnut (Juglans regia).Muir RM, Ibáñez AM, Uratsu SL, Ingham ES, Leslie CA, McGranahan GH, Batra N, Goyal S, Joseph J, Jemmis ED, Dandekar AM.Muir RM, et al.Plant Mol Biol. 2011 Apr;75(6):555-65. doi: 10.1007/s11103-011-9739-3. Epub 2011 Jan 30.Plant Mol Biol. 2011.PMID:21279669Free PMC article.
- Pentagalloyl glucose-stabilized decellularized bovine jugular vein valved conduits as pulmonary conduit replacement.Sinha D, Nagy-Mehesz A, Simionescu D, Mayer JE Jr, Vyavahare N.Sinha D, et al.Acta Biomater. 2023 Oct 15;170:97-110. doi: 10.1016/j.actbio.2023.08.036. Epub 2023 Aug 22.Acta Biomater. 2023.PMID:37619898Free PMC article.
MeSH terms
Substances
Related information
LinkOut - more resources
Full Text Sources
Other Literature Sources