Case Reports
doi: 10.1002/(SICI)1096-8652(199604)51:4<276::AID-AJH5>3.0.CO;2-T.Hemoglobin Debrousse (beta 96[FG3]Leu-->Pro): a new unstable hemoglobin with twofold increased oxygen affinity
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- PMID:8602627
- DOI: 10.1002/(SICI)1096-8652(199604)51:4<276::AID-AJH5>3.0.CO;2-T
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Case Reports
Hemoglobin Debrousse (beta 96[FG3]Leu-->Pro): a new unstable hemoglobin with twofold increased oxygen affinity
P Lacan et al. Am J Hematol.1996 Apr.
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Abstract
Hemoglobin Debrousse (beta 96[FG3]Leu-->Pro) is a new unstable variant, with high oxygen affinity responsible, in the steady state, for an apparently well-compensated chronic hemolytic anemia. The functional properties of this variant are due to the replacement of a leucine residue which is involved in the hydrophobic environment of the proximal side of the heme. This electrophoretically neutral hemoglobin was found as a de novo case in a 6-year-old girl suffering from severe anemia with hemolysis and transient aplastic crisis, following infection by parvovirus B19.
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