doi: 10.1128/JVI.70.1.663-666.1996.
bcl-2 alters influenza virus yield, spread, and hemagglutinin glycosylation
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- PMID:8523590
- PMCID: PMC189863
- DOI: 10.1128/JVI.70.1.663-666.1996
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bcl-2 alters influenza virus yield, spread, and hemagglutinin glycosylation
C W Olsen et al. J Virol.1996 Jan.
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Abstract
We previously demonstrated that expression of bcl-2 in Madin-Darby canine kidney (MDCK) cells blocks influenza virus-induced apoptosis and DNA fragmentation. We show here that expression of bcl-2 also reduces the level of infectious virus production and the spread of virus in MDCK cell cultures infected at a low multiplicity of infection. This effect is associated with modified glycosylation of the hemagglutinin protein.
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