Comparative Study
doi: 10.1021/jm00212a022.Lipophilicity and serotonin agonist activity in a series of 4-substituted mescaline analogues
- PMID:836502
- DOI: 10.1021/jm00212a022
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Comparative Study
Lipophilicity and serotonin agonist activity in a series of 4-substituted mescaline analogues
D E Nichols et al. J Med Chem.1977 Feb.
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Abstract
Replacement of the 4-methoxy of mescaline with higher alkyl homologues or with bromine led to increased activity at serotonin receptors in a sheep umbilical artery preparation. This activity appears correlated with lipophilicity, as measured by 1-octanol-water partition coefficients, but drops off when the 4-substituent is about five atoms in length. It is suggested that 3,4,5-trisubhe 2,4,5-substitution pattern.
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