Emptying of intracellular Ca2+ stores releases a novel small messenger that stimulates Ca2+ influx
- PMID:8355806
- DOI: 10.1038/364809a0
Emptying of intracellular Ca2+ stores releases a novel small messenger that stimulates Ca2+ influx
Abstract
Intracellular Ca2+ signals that last more than a few minutes after the onset of stimulation depend critically on influx of extracellular Ca2+. Such Ca2+ influx can be triggered in many cell types by depletion of intracellular Ca2+ stores without detectable elevations of known messengers. The mechanism by which store depletion can control plasma membrane Ca2+ permeability remains controversial. Here we present evidence for a novel soluble mediator. Calcium depletion of a lymphocyte cell line caused the messenger to be released from intracellular organelles into the cytoplasm and to a much lesser extent into the extracellular medium. The messenger caused Ca2+ influx when applied to macrophages, astrocytoma cells, and fibroblasts and was therefore named CIF (for Ca(2+)-influx factor). CIF appears to have hydroxyls (or hydroxyl and amino groups) on adjacent carbons, a phosphate, and a M(r) under 500.
Comment in
- Calcium entry signal?Bird GS, Bian X, Putney JW Jr.Bird GS, et al.Nature. 1995 Feb 9;373(6514):481-2. doi: 10.1038/373481b0.Nature. 1995.PMID:7845458No abstract available.
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