Comparative Study
doi: 10.1007/BF00315395.Dextromethorphan O-demethylation polymorphism in Jordanians
Affiliations
- PMID:8276053
- DOI: 10.1007/BF00315395
Item in Clipboard
Comparative Study
Dextromethorphan O-demethylation polymorphism in Jordanians
Y M Irshaid et al. Eur J Clin Pharmacol.1993.
Display options
Format
Display options
Format
Abstract
The O-demethylation of dextromethorphan (DMT) to dextrorphan (DRP) was studied in 241 unrelated, healthy Jordanian volunteers (171 males, 70 females). Urine was collected for 8 h following a single oral dose of DMT bromhydrate 30 mg. A thin-layer chromatographic (TLC) technique was used to identify the metaboliser phenotype. The frequency of the poor metaboliser phenotype was found to be 2.9% (approximate 95% confidence interval 0.8-5.0%). Applying the Hardy-Weinberg Law, the frequency of the recessive autosomal gene controlling poor metabolism was 0.17 (95% confidence interval 0.108-0.232).
Similar articles
- Dextromethorphan metabolism in Jordanians: dissociation of dextromethorphan O-demethylation from debrisoquine 4-hydroxylation.Irshaid YM, al-Hadidi HF, Latif A, Awwadi F, al-Zoubi M, Rawashdeh NM.Irshaid YM, et al.Eur J Drug Metab Pharmacokinet. 1996 Oct-Dec;21(4):301-7. doi: 10.1007/BF03189731.Eur J Drug Metab Pharmacokinet. 1996.PMID:9074894
- Dextromethorphan O-demethylation in a large number of French Caucasian families.Vincent-Viry M, Fournier B, Siest G, Galteau MM.Vincent-Viry M, et al.Pharmacogenetics. 1992 Jun;2(3):135-8. doi: 10.1097/00008571-199206000-00005.Pharmacogenetics. 1992.PMID:1306113No abstract available.
- Dextromethorphan O-demethylation and dextrorphan glucuronidation in a French population.Duché JC, Quérol-Ferrer V, Barré J, Mésangeau M, Tillement JP.Duché JC, et al.Int J Clin Pharmacol Ther Toxicol. 1993 Aug;31(8):392-8.Int J Clin Pharmacol Ther Toxicol. 1993.PMID:8225685
- Enzyme polymorphism on the metabolic O-demethylation of dextromethorphan in a South American population.Estévez F, Giusti M, Parrillo S, Oxandabarat J.Estévez F, et al.Medicina (B Aires). 1996;56(4):378-82.Medicina (B Aires). 1996.PMID:9138342
- Low frequency of dextromethorphan O-demethylation deficiency in a Chinese population.Lane HY, Deng HC, Huang SM, Hu WH, Chang WH, Hu OY.Lane HY, et al.Clin Pharmacol Ther. 1996 Dec;60(6):696-8. doi: 10.1016/S0009-9236(96)90219-2.Clin Pharmacol Ther. 1996.PMID:8988073Review.No abstract available.
Cited by
- Metabolic capacity of CYP2D6 within an Iranian population (Mazandaran Province).Shiran MR, Sarzare F, Merat F, Salehifar E, Moghadamnia AA, Hashemi Soteh SM.Shiran MR, et al.Caspian J Intern Med. 2011 Spring;2(2):213-7.Caspian J Intern Med. 2011.PMID:24024018Free PMC article.
- Dextromethorphan metabolic phenotyping in an Iranian population.Afshar M, Rouini M, Ala S.Afshar M, et al.Eur J Clin Pharmacol. 2005 Feb;60(12):849-54. doi: 10.1007/s00228-004-0859-4. Epub 2005 Jan 19.Eur J Clin Pharmacol. 2005.PMID:15657780
- Dextromethorphan metabolism in Jordanians: dissociation of dextromethorphan O-demethylation from debrisoquine 4-hydroxylation.Irshaid YM, al-Hadidi HF, Latif A, Awwadi F, al-Zoubi M, Rawashdeh NM.Irshaid YM, et al.Eur J Drug Metab Pharmacokinet. 1996 Oct-Dec;21(4):301-7. doi: 10.1007/BF03189731.Eur J Drug Metab Pharmacokinet. 1996.PMID:9074894
References
Publication types
MeSH terms
Substances
Related information
LinkOut - more resources
Full Text Sources