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.1994 Sep 15;371(6494):221-6.
doi: 10.1038/371221a0.

An early haematopoietic defect in mice lacking the transcription factor GATA-2

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An early haematopoietic defect in mice lacking the transcription factor GATA-2

F Y Tsai et al. Nature..

Abstract

Blood cell development relies on the expansion and maintenance of haematopoietic stem and progenitor cells in the embryo. By gene targeting in mouse embryonic stem cells, we demonstrate that the transcription factor GATA-2 plays a critical role in haematopoiesis, particularly of an adult type. We propose that GATA-2 regulates genes controlling growth factor responsiveness or the proliferative capacity of early haematopoietic cells.

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