Prevention of folic acid-preventable spina bifida and anencephaly
- PMID:8005026
- DOI: 10.1002/9780470514559.ch13
Prevention of folic acid-preventable spina bifida and anencephaly
Abstract
The results of the British Medical Research Council's randomized controlled trial proved that folic acid can prevent spina bifida and anencephaly. The trial provided critical scientific data upon which to base public health policy for preventing folic acid-preventable spina bifida and anencephaly. Within weeks of publication of the results, the Centers for Disease Control and Prevention in the US developed and issued guidelines for women who had had a pregnancy affected by spina bifida or anencephaly. A year later, the US Public Health Service issued the recommendation that all women of child-bearing age who are capable of becoming pregnant should consume 0.4 mg of folic acid per day. The Public Health Service needed a year to make inferential judgements about dose, target groups, safety, timing of ingestion, and existing and proposed vitamin and drug policies and regulations. Current policy discussions concern whether to permit manufacturers of vitamins or food products to claim that folic acid will prevent folic acid-preventable spina bifida and anencephaly and whether to allow a food staple to be fortified with folic acid.
Similar articles
- High potential for reducing folic acid-preventable spina bifida and anencephaly, and related stillbirth and child mortality, in Ethiopia.Dixon M, Kancherla V, Magana T, Mulugeta A, Oakley GP Jr.Dixon M, et al.Birth Defects Res. 2019 Nov 15;111(19):1513-1519. doi: 10.1002/bdr2.1584. Epub 2019 Aug 19.Birth Defects Res. 2019.PMID:31424635
- Update on prevention of folic acid-preventable spina bifida and anencephaly.Bell KN, Oakley GP Jr.Bell KN, et al.Birth Defects Res A Clin Mol Teratol. 2009 Jan;85(1):102-7. doi: 10.1002/bdra.20504.Birth Defects Res A Clin Mol Teratol. 2009.PMID:19067404
- Countries with an immediate potential for primary prevention of spina bifida and anencephaly: Mandatory fortification of wheat flour with folic acid.Kancherla V.Kancherla V.Birth Defects Res. 2018 Jul 3;110(11):956-965. doi: 10.1002/bdr2.1222. Epub 2018 Mar 13.Birth Defects Res. 2018.PMID:29532629
- The scientific basis for eliminating folic acid-preventable spina bifida: a modern miracle from epidemiology.Oakley GP Jr.Oakley GP Jr.Ann Epidemiol. 2009 Apr;19(4):226-30. doi: 10.1016/j.annepidem.2009.01.016.Ann Epidemiol. 2009.PMID:19344858Review.
- Recommendations for the use of folic acid to reduce the number of cases of spina bifida and other neural tube defects.[No authors listed][No authors listed]MMWR Recomm Rep. 1992 Sep 11;41(RR-14):1-7.MMWR Recomm Rep. 1992.PMID:1522835Review.
Cited by
- Spinal dysraphism: a neurosurgical review for the urologist.Netto JM, Bastos AN, Figueiredo AA, Pérez LM.Netto JM, et al.Rev Urol. 2009 Spring;11(2):71-81.Rev Urol. 2009.PMID:19680528Free PMC article.
- Identification of MicroRNA Profiles in Fetal Spina Bifida: The Role in Pathomechanism and Diagnostic Significance.Buczyńska A, Sidorkiewicz I, Niemira M, Krętowski AJ, Węgrzyn P, Kosiński P, Zbucka-Krętowska M.Buczyńska A, et al.Int J Mol Sci. 2024 Mar 1;25(5):2896. doi: 10.3390/ijms25052896.Int J Mol Sci. 2024.PMID:38474143Free PMC article.
- Prevention of chronic kidney disease in spina bifida.Filler G, Gharib M, Casier S, Lödige P, Ehrich JH, Dave S.Filler G, et al.Int Urol Nephrol. 2012 Jun;44(3):817-27. doi: 10.1007/s11255-010-9894-5. Epub 2011 Jan 13.Int Urol Nephrol. 2012.PMID:21229390Review.
- Periconceptional folic acid supplementation and sex difference in prevention of neural tube defects and their subtypes in China: results from a large prospective cohort study.Liu J, Li Z, Ye R, Liu J, Ren A.Liu J, et al.Nutr J. 2018 Dec 12;17(1):115. doi: 10.1186/s12937-018-0421-3.Nutr J. 2018.PMID:30541549Free PMC article.
- Epigenetic and transgenerational mechanisms in infection-mediated neurodevelopmental disorders.Weber-Stadlbauer U.Weber-Stadlbauer U.Transl Psychiatry. 2017 May 2;7(5):e1113. doi: 10.1038/tp.2017.78.Transl Psychiatry. 2017.PMID:28463237Free PMC article.Review.
Publication types
MeSH terms
Substances
Related information
LinkOut - more resources
Medical