doi: 10.1073/pnas.91.11.5109.
Molecular and functional analysis of a lymphocyte chemoattractant factor: association of biologic function with CD4 expression
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- PMID:7910967
- PMCID: PMC43941
- DOI: 10.1073/pnas.91.11.5109
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Molecular and functional analysis of a lymphocyte chemoattractant factor: association of biologic function with CD4 expression
W W Cruikshank et al. Proc Natl Acad Sci U S A..
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Abstract
Lymphocyte chemoattractant factor (LCF) is a lymphocyte cell product that stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. In concert with its chemoattractant activity, LCF induces human T-lymphocyte expression of interleukin 2 receptor. Here we describe the molecular cloning of cDNA encoding human LCF. It is a novel interleukin with no significant homology to any previously described cytokine families. There is an absolute requirement for both autoaggregation of LCF monomers and for membrane-expressed CD4 molecules for LCF-induced migration in lymphocytes.
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