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.1994 Dec;3(12):2159-61.
doi: 10.1093/hmg/3.12.2159.

Construction of human Y-chromosomal haplotypes using a new polymorphic A to G transition

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Construction of human Y-chromosomal haplotypes using a new polymorphic A to G transition

M T Seielstad et al. Hum Mol Genet.1994 Dec.

Abstract

We report the discovery of a polymorphic A to G transition found on the human Y chromosome by sequencing Y-specific sequence-tagged sites (STSs). It shows maximal linkage disequilibrium with a previously described Alu insertional polymorphism. We analyze further an apparently African Y chromosome which seems to have entered a Mexican Mayan population several generations ago. Using the newly discovered transition and the Y-specific polymorphic Alu insertion, we discuss how the chromosome's haplotype information might be used to answer questions of human origins and migrations.

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