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Review
.1995 Jan 13;270(2):503-6.
doi: 10.1074/jbc.270.2.503.

Lipid modifications of trimeric G proteins

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Review

Lipid modifications of trimeric G proteins

P B Wedegaertner et al. J Biol Chem..
Free article

Abstract

G protein alpha subunits and beta gamma dimers are covalently modified by lipids. The emerging picture is one in which attached lipids provide more than just a nonspecific "glue" for sticking G proteins to membranes. We are only beginning to understand how different lipid modifications of different G protein subunits affect specific protein-protein interactions and localization to specific cellular sites. In addition, regulation of these modifications, particularly palmitoylation, can provide new ways to regulate signals transmitted by G proteins.

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