doi: 10.1007/BF00713052.
Mapping of gene loci in the Q13-Q15 region of chromosome 12
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- PMID:7606365
- DOI: 10.1007/BF00713052
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Mapping of gene loci in the Q13-Q15 region of chromosome 12
E L Mitchell et al. Chromosome Res.1995 Jun.
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Abstract
The gene loci CDK4, GLI, CHOP and MDM2 have been mapped to the q13-q15 region of chromosome 12. Using fluorescence in situ hybridization onto simultaneously DAPI-banded metaphase chromosomes and interphase nuclei, we have more precisely mapped and ordered these loci, together with a number of Genethon microsatellite markers. GLI and CHOP localize to 12q13.3-14.1, CDK4 to 12q14 and MDM2 to 12q14.3-q15, and the gene order is cen-GLI/CHOP-CDK4-MDM2. The Genethon microsatellites D12S80 and D12S83 flank MDM2.
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