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.1983 May;79(1):3-5.
doi: 10.1111/j.1476-5381.1983.tb10485.x.

Contraction and increase in tissue calcium content induced by maitotoxin, the most potent known marine toxin, in intestinal smooth muscle

Contraction and increase in tissue calcium content induced by maitotoxin, the most potent known marine toxin, in intestinal smooth muscle

Y Ohizumi et al. Br J Pharmacol.1983 May.

Abstract

Maitotoxin (MTX), the most potent known marine toxin, isolated from toxic dinoflagellates and poisonous fish, caused a dose-dependent contraction of the guinea-pig isolated ileum and taenia caeci at concentrations of 100 pg to 30 ng/ml. These contractile responses to MTX (3 ng/ml) in both tissues were abolished by incubation in Ca2+-free solution and were markedly inhibited by treatment with methoxyverapamil (D600), but were not affected by tetrodotoxin and atropine. Furthermore, MTX markedly elevated tissue Ca2+ content of the taenia caeci. These results suggest that MTX activates Ca2+ channels in the smooth muscle membrane of both tissues to increase Ca2+ influx and thus induces contractions.

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References

    1. Physiol Rev. 1974 Oct;54(4):813-89 - PubMed
    1. Pharmacol Rev. 1978 Jun;30(2):167-208 - PubMed
    1. Annu Rev Pharmacol Toxicol. 1980;20:15-43 - PubMed
    1. J Pharmacol Exp Ther. 1980 Jul;214(1):209-12 - PubMed
    1. J Pharmacol Exp Ther. 1981 May;217(2):475-80 - PubMed

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