doi: 10.1016/0014-2999(84)90247-4.
Sensitization of rat forebrain neurons to serotonin by adinazolam, an antidepressant triazolobenzodiazepine
- PMID:6734729
- DOI: 10.1016/0014-2999(84)90247-4
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Sensitization of rat forebrain neurons to serotonin by adinazolam, an antidepressant triazolobenzodiazepine
A Turmel et al. Eur J Pharmacol..
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Abstract
Adinazolam , a triazolobenzodiazepine , has been reported to be an effective antidepressant treatment in major depression. In the present study, a 14-day (but not a five-day) treatment with adinazolam enhanced the responsiveness of rat hippocampal pyramidal neurons to microiontophoretically applied 5-HT but not to NE. A 14-day treatment with diazepam failed to induce sensitization to either 5-HT or NE. Acute intravenous administration of adinazolam did not modify dorsal raphe 5-HT neuron firing rate. It is proposed that the antidepressant activity of adinazolam might be mediated by a heightened 5-HT neurotransmission.
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