Bone formation and resorption as the determinants of trabecular bone volume in postmenopausal osteoporosis
- PMID:6114324
- DOI: 10.1016/s0140-6736(81)90526-2
Bone formation and resorption as the determinants of trabecular bone volume in postmenopausal osteoporosis
Abstract
Histomorphometry has been applied to trabecular bone samples obtained post-mortem from young and old women without known bone disease and to bone biopsy specimens from patients with postmenopausal osteoporosis. Bone volume was significantly lower in the old than young controls and significantly lower again in the osteoporotics. The loss of bone with age associated with a rise in surface resorption but no change in forming surface, and the further loss in osteoporotics was associated with a further rise in resorption and a small non-significant fall in forming surfaces. It is suggested that trabecular bone volume is determined by the relation between total forming surface on the one hand and percent surface resorption on the other, and this relationship is expressed in mathematical terms. Age-related bone loss (simple osteoporosis) in women is accounted for by increased resorption, and accelerated osteoporosis is mainly due to a further increase in resorption.
Similar articles
- Bone formation and resorption as the determinants of trabecular bone volume in normal and osteoporotic men.Nordin BE, Aaron J, Speed R, Francis RM, Makins N.Nordin BE, et al.Scott Med J. 1984 Jul;29(3):171-5. doi: 10.1177/003693308402900307.Scott Med J. 1984.PMID:6533788
- Bone formation and resorption in postmenopausal osteoporosis.Nordin BE.Nordin BE.Lancet. 1981 Sep 26;2(8248):695. doi: 10.1016/s0140-6736(81)91026-6.Lancet. 1981.PMID:6116072No abstract available.
- Bone formation and resorption in postmenopausal osteoporosis.Darby AJ.Darby AJ.Lancet. 1981 Sep 5;2(8245):536. doi: 10.1016/s0140-6736(81)90931-4.Lancet. 1981.PMID:6115291No abstract available.
- A unitary model for involutional osteoporosis: estrogen deficiency causes both type I and type II osteoporosis in postmenopausal women and contributes to bone loss in aging men.Riggs BL, Khosla S, Melton LJ 3rd.Riggs BL, et al.J Bone Miner Res. 1998 May;13(5):763-73. doi: 10.1359/jbmr.1998.13.5.763.J Bone Miner Res. 1998.PMID:9610739Review.
- Reduced bone formation and increased bone resorption: rational targets for the treatment of osteoporosis.Seeman E.Seeman E.Osteoporos Int. 2003;14 Suppl 3:S2-8. doi: 10.1007/s00198-002-1340-9. Epub 2003 Mar 19.Osteoporos Int. 2003.PMID:12730770Review.
Cited by
- Skeletal alterations in ovariectomized rats.Wronski TJ, Lowry PL, Walsh CC, Ignaszewski LA.Wronski TJ, et al.Calcif Tissue Int. 1985 May;37(3):324-8. doi: 10.1007/BF02554882.Calcif Tissue Int. 1985.PMID:3926284
- Calcium supplementation of the diet: justified by present evidence.Nordin BE, Heaney RP.Nordin BE, et al.BMJ. 1990 Apr 21;300(6731):1056-60. doi: 10.1136/bmj.300.6731.1056.BMJ. 1990.PMID:2188698Free PMC article.Review.No abstract available.
- Increased cancellous bone in the femoral neck of patients with coxarthrosis (hip osteoarthritis): a positive remodeling imbalance favoring bone formation.Jordan GR, Loveridge N, Power J, Clarke MT, Reeve J.Jordan GR, et al.Osteoporos Int. 2003 Apr;14(2):160-5. doi: 10.1007/s00198-002-1351-6. Epub 2003 Mar 5.Osteoporos Int. 2003.PMID:12730795
- The hormonal form of vitamin D in the pathophysiology and therapy of postmenopausal osteoporosis.Caniggia A, Nuti R, Loré F, Vattimo A.Caniggia A, et al.J Endocrinol Invest. 1984 Aug;7(4):373-8. doi: 10.1007/BF03351019.J Endocrinol Invest. 1984.PMID:6094649
- Increase in serum bone gamma-carboxyglutamic acid protein with aging in women. Implications for the mechanism of age-related bone loss.Delmas PD, Stenner D, Wahner HW, Mann KG, Riggs BL.Delmas PD, et al.J Clin Invest. 1983 May;71(5):1316-21. doi: 10.1172/jci110882.J Clin Invest. 1983.PMID:6304145Free PMC article.
MeSH terms
Substances
Related information
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical