Addressing retinal hypoxia: pathophysiology, therapeutic innovations, and future prospects
- PMID:39376745
- PMCID: PMC11457288
- DOI: 10.1177/25158414241280187
Addressing retinal hypoxia: pathophysiology, therapeutic innovations, and future prospects
Abstract
Retinal hypoxia stands as a pivotal yet often underappreciated factor in the etiology and progression of many retinal disorders such as glaucoma, hypertensive retinopathy, diabetic retinopathy, retinal vein occlusions, and retinal artery occlusions. Current treatment methodologies fail to directly address the underlying pathophysiology of hypoxia and aim to improve ischemia through alternative methods. In this review, we discuss the critical role of retinal hypoxia in the pathogenesis of various retinal diseases and highlight the need for innovative therapeutic strategies that address the root cause of these conditions. As our understanding of retinal hypoxia continues to evolve, the emergence of new technologies holds the promise of more effective treatments, offering hope to patients at risk of vision loss.
Keywords: hypoxia; oxygen nanodelivery; oxygen therapy; retina; retinal hypoxia.
Plain language summary
A review of old and new therapeutic strategies for addressing oxygen deprivation in retinal diseases This paper talks about how lack of oxygen in the retina can cause different eye diseases like glaucoma, diabetic retinopathy, and retinal artery occlusions. It explains how our current treatments don’t directly fix this lack of oxygen, but rather try to help in other ways. The paper also discusses the science behind why these diseases happen and what happens in the eye when there’s not enough oxygen. Ultimately, we finish our discussion with an overview of novel technology that are currently being used in other fields and could be applied in these eye disorders.
© The Author(s), 2024.
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